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Benzyl ether

Benzyl ether Structure
Benzyl ether structure
CAS No.
103-50-4
Chemical Name:
Benzyl ether
Synonyms
DIBENZYL ETHER;(Oxybis(Methylene))dibenzene;FEMA 2371;benzyloxide;Benzyl oxide;BENZYL ETHER;ibenzylether;Dibenzylather;Dibenzyl ethe;plasticatorba
CBNumber:
CB8258535
Molecular Formula:
C14H14O
Molecular Weight:
198.26
MDL Number:
MFCD00004780
MOL File:
103-50-4.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-06-24 18:39:39
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Benzyl ether Properties

Melting point 1.5-3.5 °C(lit.)
Boiling point 298 °C(lit.)
Density 1.043 g/mL at 25 °C(lit.)
vapor pressure <1 Pa (25 °C)
FEMA 2371 | DIBENZYL ETHER
refractive index n20/D 1.562
FLAVIS Number 03.004 | Dibenzyl ether
Flash point 275 °F
storage temp. 2-8°C
solubility 42mg/l insoluble
form Liquid
color Clear colorless to pale yellow
Relative polarity 3.3
Odor at 100.00 %. sweet fruity cherry earthy mushroom rose plastic
Odor Type earthy
biological source synthetic
Water Solubility insoluble
Merck 14,1132
JECFA Number 1256
BRN 1911156
Henry's Law Constant 1.5×100 mol/(m3Pa) at 25℃, Duchowicz et al. (2020)
Dielectric constant 3.8599999999999999
Stability Stable. Combustible. Incompatible with strong acids, strong oxidizing agents.
Cosmetics Ingredients Functions PERFUMING
InChI 1S/C14H14O/c1-3-7-13(8-4-1)11-15-12-14-9-5-2-6-10-14/h1-10H,11-12H2
InChIKey MHDVGSVTJDSBDK-UHFFFAOYSA-N
SMILES C(OCc1ccccc1)c2ccccc2
LogP 3.31
CAS DataBase Reference 103-50-4(CAS DataBase Reference)
Substances Added to Food (formerly EAFUS) DIBENZYL ETHER
FDA 21 CFR 172.515
EWG's Food Scores 1
FDA UNII 2O6CNO27RJ
NIST Chemistry Reference Benzene, 1,1'-[oxybis(methylene)]bis-(103-50-4)
EPA Substance Registry System Benzyl ether (103-50-4)
UNSPSC Code 85151701
NACRES NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)Environment (GHS09)
GHS07,GHS09
Signal word  Warning
Hazard statements  H317-H410
Precautionary statements  P261-P272-P273-P280-P302+P352-P333+P313
PPE Eyeshields, Gloves, type ABEK (EN14387) respirator filter
Hazard Codes  Xi,N
Risk Statements  36/37/38-51/53
Safety Statements  23-61
RIDADR  UN 3082 9/PG 3
WGK Germany  2
RTECS  DQ6125000
F  9
Autoignition Temperature 470 °C
TSCA  TSCA listed
HS Code  2909 30 90
HazardClass  9
PackingGroup  III
Storage Class 10 - Combustible liquids
Hazard Classifications Aquatic Acute 1
Aquatic Chronic 1
Skin Sens. 1B
Hazardous Substances Data 103-50-4(Hazardous Substances Data)
Toxicity LD50 orally in Rabbit: 2500 mg/kg
REACH Registrations Active
Limited Quantities 5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid)
Excepted Quantities Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)
NFPA 704
1
1 0

Benzyl ether price More Price(45)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich W237108 Benzyl ether ≥98%, FCC, FG 103-50-4 1 each $57.7 2026-04-30 Buy
Sigma-Aldrich W237108 Benzyl ether ≥98%, FCC, FG 103-50-4 1kg $110 2026-04-30 Buy
Sigma-Aldrich Y0001628 Tribenoside impurity D European Pharmacopoeia (EP) Reference Standard 103-50-4 100 mg $241 2026-04-30 Buy
Sigma-Aldrich W237108 Benzyl ether ≥98%, FCC, FG 103-50-4 10Kg $486 2026-04-30 Buy
Sigma-Aldrich 108014 Benzyl ether 98% 103-50-4 1kg $66.3 2026-04-30 Buy
Product number Packaging Price Buy
W237108 1 each $57.7 Buy
W237108 1kg $110 Buy
Y0001628 100 mg $241 Buy
W237108 10Kg $486 Buy
108014 1kg $66.3 Buy

Benzyl ether Chemical Properties, Uses, Production

Chemical Properties

Dibenzyl ether is a clear, almost colorless liquid. It is miscible with alcohols and ethers, but insoluble in water. Dibenzyl ether is used as special solvent and delustering agent for textiles.

Chemical Properties

Dibenzyl ether has a slightly earthy, mushroom-like odor with a rosy undertone.

Uses

Benzyl ether is used as an effective GFP friendly tissue clearing medium for mouse brains. It is also used in a study to develop a detailed protocol for performing 3D imaging of solvent-cleared organs and its application to various microscopy techniques. It is also employed as a plasticizer for nitrocellulose and synthetic rubber, a solvent in perfumery, and a flavoring agent in chewing gums and baked goods. It can also be used as a plasticizer for nitrocellulose and a solvent in spices.

Application

Benzyl ether is an aromatic ether that is commonly employed as a protecting agent and benzylating agent. It is a plasticizer for nitrocellulose and a solvent in perfumery.

Preparation

As a by-product in the preparation of benzyl alcohol by hydrolysis of benzyl chloride; by using a concentrated caustic instead of carbonate, yields can be improved to 50% or higher.

Definition

ChEBI: Dibenzyl ether is a benzyl ether in which the oxygen atom is connected to two benzyl groups. It has a role as a metabolite.

General Description

Colorless liquid with a mild odor.

Air & Water Reactions

Oxidizes readily in air to form unstable peroxides that may explode spontaneously [Bretherick, 1979 p.151-154, 164]. Insoluble in water.

Reactivity Profile

Benzyl ether can act as a base to form salts with strong acids and addition complexes with Lewis acids. May react violently with strong oxidizing agents. Burns readily but relatively inert in other reactions, which typically involve the breaking of the carbon-oxygen bond.

Hazard

Moderately toxic by ingestion. A skin irri- tant.

Health Hazard

Inhalation may cause nausea because of disagreeable odor. Contact of liquid with eyes causes mild irritation. Prolonged exposure of skin to liquid causes reddening and irritation. Ingestion produces nausea.

Fire Hazard

Benzyl ether is combustible.

Synthesis

Benzyl ether is formed when benzyl alcohol is heated with strong acids or bases. It is produced almost exclusively by the alkaline hydrolysis of benzyl chloride. Heat treatment decomposes dibenzyl ether into benzaldehyde and toluene.

Purification Methods

Reflux the ether over sodium, then distil it under reduced pressure. It been purified by fractional freezing. [Beilstein 6 IV 2240.]

Benzyl ether synthesis

100-52-7
103-50-4
Synthesis of Benzyl ether from Benzaldehyde

Benzyl ether Preparation Products And Raw materials

Raw materials

Benzyl chloride Benzyl alcohol Benzyl chloromethyl ether Benzyl 4-Phenylbutanoate Benzyl ethyl ether
1-Adamantanol Benzyl 2-bromoacetate Benzyl benzoate 4-Phenylbutyric acid Benzyl propargyl ether
1,3-Diphenyl-1,1,3,3-tetramethyldisiloxane Benzaldehyde

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Preparation Products

3-Hydroxy-2-methyl-4H-pyran-4-one Ethyl maltol Adipic acid dibenzyl ester 1-Methyl-1,4-cyclohexadiene Hexaphenyldisiloxane
sec-Butyl ether Benzoyl bromide

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Benzyl ether Suppliers

Global Suppliers ( 391)
Supplier Tel Email Country ProdList Advantage
Macheng jinxin biotechnology co., LTD 18271582018 1126319697@qq.com China 1525 58
Wuhan Biet Co., Ltd. 027-83698488 15271884849 min@biet.com.cn China 68 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Beijing HwrkChemical Technology Co., Ltd 89508211 18501085097 sales.bj@hwrkchemical.com China 9407 55
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Beijing Ouhe Technology Co., Ltd 13552068683 13522913783 2355560935@qq.com China 11777 60
Shandong Xiya Chemical Co., Ltd 13355009207 13355009207 3007715519@qq.com China 18722 57
Supplier Advantage
Macheng jinxin biotechnology co., LTD 58
Wuhan Biet Co., Ltd. 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
Beijing HwrkChemical Technology Co., Ltd 55
Energy Chemical 61
Beijing Ouhe Technology Co., Ltd 60
Shandong Xiya Chemical Co., Ltd 57

Related articles

Related Questions

Ask a question
Q:What precautions should be taken when using benzyl ether in catalytic hydrocracking?STAR - Mar 31,2026
A:Benzyl ether is one of the most widely used protecting groups of alcohols since it is easily installed, stable to a broad scope of reaction conditions and readily re moved in the presence of many common functionalities through hydrogenation, dissolving metal reduction, oxi dative treatments, or Lewis acid mediated cleavage. Among these, catalytic hydrocracking is the mildest method for removing the benzyl protecting group. When designing benzyl-based protecting group strategies, consideration should be given to the possibility that other oxygen-containing benzyl groups may be affected. Taking this potential drawback into account, selective deprotection reactions can be achieved through careful evaluation of the catalyst, solvent and concentration. For example, by employing a suitable two-step hydrogenolysis sequence using 10% Pd/C and Rh/Al2O3 catalysts in sequence, the hydrogenolysis of aliphatic and aromatic O-benzyl protecting groups has been successfully achieved in the presence of benzyl methyl ether.

View Latest Price from Benzyl ether manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
dibenzyl ether pictures 2026-09-17 dibenzyl ether
103-50-4
 1KG 93% 100 Wuhan Biet Co., Ltd.
Benzyl ether pictures 2026-03-20 Benzyl ether
103-50-4
 $10.00 1KG 99% 10 mt Hebei Chuanghai Biotechnology Co., Ltd
Benzyl ether pictures 2025-12-24 Benzyl ether
103-50-4
 1KG 99.0% 1000 tons Shaanxi Dideu Medichem Co. Ltd
  • Benzyl ether pictures
  • Benzyl ether
    103-50-4
  • $10.00
  • 99%
  • Hebei Chuanghai Biotechnology Co., Ltd
  • Benzyl ether pictures
  • Benzyl ether
    103-50-4
  • $0.10
  • 99.0%
  • Shaanxi Dideu Medichem Co. Ltd

Benzyl ether Spectrum

Benzyl ether(103-50-4)MSBenzyl ether(103-50-4)1HNMRBenzyl ether(103-50-4)13CNMRBenzyl ether(103-50-4)IR1Benzyl ether(103-50-4)IR2Benzyl ether(103-50-4)Raman

103-50-4 (Benzyl ether) Related Search:

Benzyl isocyanate Dimethyl ether 2-Butoxyethanol Benzyl chloride Benzyl alcohol
Benzyl benzoate Benzyl nicotinate Ethylbenzene Tribenoside EP Impurity B Tribenoside
1,2-O-Isopropylidene-3,5,6-tri-O-benzyl-alpha-D-glucofuranose TRIBENOSIDE IMPURITY A Benzyl 2-(Phenylmethoxy)-naphthalene 5(6)-Aminofluorescein
2',7'-Dichlorofluorescein Diethyl ether Phenolphthalein diphosphate tetrasodium salt

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Tribenoside impurity D [(Benzyloxy)methyl]benzene 1,1-[oxybis(methylene)]bis[benzene] 1,1’-(oxybis(methylene))bis-benzen 1,1’-[oxybis(methylene)]bis-benzen 1,1’-[oxybis(methylene)]bis-Benzene 1,1’-oxybis(methylene-benzen BA (Plasticizer) ba(plasticizer) ba[plasticizer] Benzene,1,1’-(oxybis[methylene])bis- Benzyl oxide benzyloxide benzyloxide(czech) Dibenzylather dibenzylether(czech) Benzyl ether,99% Benzyl ether, 99% 1LT (Oxybis(methylene) DIBENZYL ETHER FOR SYNTHESIS Dibenzyl ethe Benzyl ether 98% Dibenzyl ether puruM, >=98.0% (GC) Benzyl Alcohol Impurity 5 Benzyl Alcohol Impurity E ether,dibenzyl femanumber2371 plasticatorba Plastikator BA plastikatorba BENZYL ETHER BENZYL ETHER 98+% FCC DIBENZYL ETHER / BENZYL ETHER Dibenzyl ether, 98+% DIBENZYL ETHER pure Bisbenzyl ether α,α'-Oxybistoluene Dibenzyl Ether > Tribenoside impurity D CRS DIBENZYL ETHER FOR SYNTHESIS 1 L DIBENZYL ETHER FOR SYNTHESIS 100 ML Tribenoside EP Impurity D Tribenoside Impurity 4（Tribenoside EP Impurity D） ibenzylether Benzyl ether USP/EP/BP (Oxybis(Methylene))dibenzene DIBENZYL ETHER FEMA 2371 103-50-4 C6H5CH2OCH2C6H5 C6H5CH22O Ion Sensor Materials Organic Building Blocks Ethers Plasticizer for ISE Oxygen Compounds Building Blocks Analytical Chromatography Product Catalog