CAY10526
- CAS No.
- 938069-71-7
- Chemical Name:
- CAY10526
- Synonyms
- CAY10526;CAY10526 Exclusive;CAY10526, 10 mM in DMSO;2(5H)-Furanone, 4-benzo[b]thien-2-yl-3-bromo-5-hydroxy-;3-(1-benzothiophen-2-yl)-4-bromo-2-hydroxy-2H-furan-5-one;4-(Benzo[b]thiophen-2-yl)-3-bromo-5-hydroxyfuran-2(5H)-one;4-(Benzo[b]thiophen-2-yl)-3-bromo-5-hydroxydihydrofuran-2(3H)-one;WM793,PGE2 production,Inhibitor,inhibit,SB2,microsomal PGE2 synthase-1,A375,cleaved caspase 3,CAY10526,increases apoptosis,increases BAX and BAK,pro-apoptotic,anti-apoptotic,melanoma xenografts,mPGES1 inhibitor,PGE synthase,Prostaglandin E synthase
- CBNumber:
- CB82590422
- Molecular Formula:
- C12H7BrO3S
- Molecular Weight:
- 311.15
- MDL Number:
- MFCD18432686
- MOL File:
- 938069-71-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 561.7±50.0 °C(Predicted) |
|---|---|
| Density | 1.889±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 1 mg/ml |
| form | A crystalline solid |
| pka | 8.90±0.60(Predicted) |
| color | Off-white to yellow |
| InChI | 1S/C12H7BrO3S/c13-10-9(11(14)16-12(10)15)8-5-6-3-1-2-4-7(6)17-8/h1-5,11,14H |
| InChIKey | ICCDILPNCJIDAW-UHFFFAOYSA-N |
| SMILES | O=C1OC(C(C2=CC3=C(S2)C=CC=C3)=C1Br)O |
| UNSPSC Code | 51111800 |
| NACRES | NA.77 |
CAY10526 price More Price(37)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML2530 | CAY10526 ≥98% (HPLC) | 938069-71-7 | 5 mg | $210 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML2530 | CAY10526 ≥98% (HPLC) | 938069-71-7 | 25 mg | $662 | 2026-04-30 | Buy |
| Cayman Chemical | 10010088 | CAY10526 ≥98% | 938069-71-7 | 1mg | $63 | 2026-04-30 | Buy |
| Cayman Chemical | 10010088 | CAY10526 ≥98% | 938069-71-7 | 5mg | $274 | 2026-04-30 | Buy |
| Cayman Chemical | 10010088 | CAY10526 ≥98% | 938069-71-7 | 10mg | $481 | 2026-04-30 | Buy |
CAY10526 Chemical Properties, Uses, Production
Description
Prostaglandin E2 (PGE2) is the major PG synthesized at sites of inflammation and plays an important role in different inflammatory diseases. It acts as a mediator of pain and inflammation and promotes bone destruction. The increased synthesis of PGE2 during inflammation can be accounted for by increased expression of both cyclooxygenase-
Uses
CAY10526 is a specific microsomal PGE2 synthase-1 (mPGES1) inhibitor. CAY10526 inhibits PGE2 production through the selective modulation of mPGES1 expression but does not affect COX-2. CAY10526 significantly suppresses tumor growth and increases apoptosis in melanoma xenografts. CAY10526 reduces BCL-2 and BCL-XL (anti-apoptotic) protein levels and increases BAX and BAK (pro-apoptotic) as well as cleaved caspase 3 levels. CAY10526 inhibits cell viability (IC50<5 μM) in three melanoma cell lines expressing mPGES1[1].
References
[1] Sun-Hee Kim, et al. Microsomal PGE2 synthase-1 regulates melanoma cell survival and associates with melanoma disease progression. Pigment Cell Melanoma Res. 2016 May;29(3):297-308. DOI:10.1111/pcmr.12455
CAY10526 Preparation Products And Raw materials
Raw materials
Preparation Products
CAY10526 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Beckham Medical Technology Co., Ltd | 13816613772 | huahero21@sina.com | China | 2994 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Shanghai Rechem science Co., Ltd. | 021-31433387 15618786686 | sales@rechemscience.com | China | 2969 | 58 |
| Shanghai Haohong Pharmaceutical Co., Ltd. | 400-8210725 400821072 | malulu@leyan.com | China | 24933 | 58 |
| Shanghai Han-Xiang Chemical Co., Ltd. | 17754423994 | candy@biochempartner.com | China | 3057 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| Taizhou Nanfeng Pharmaceutical Research Institute | nanfengpharma@126.co 18616377689 | nanfengpharma@126.com | China | 20008 | 58 |
