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KukoaMine B

KukoaMine B Structure
KukoaMine B structure
CAS No.
164991-67-7
Chemical Name:
KukoaMine B
Synonyms
Kukoamine B DiHCl;Geoscutin;KukoaMine B;Kukoamine B-D8;KukoaMine B (Standard);Resorcinol Impurity 30;Dihydroxybenzenepropanamide;N-(3-Aminopropyl)-3-(3,4-dihydroxyphenyl)-N-(4-((3-(3-(3,4-dihydroxyphenyl)propanamido)propyl)amino)butyl)propanamide;Benzenepropanamide,N-(3-aminopropyl)-N-[4-[[3-[[3-(3,4-dihydroxyphenyl)-1-oxopropyl]amino]propyl]amino]butyl]-3,4-dihydroxy-
CBNumber:
CB82602352
Molecular Formula:
C28H42N4O6
Molecular Weight:
530.66
MDL Number:
MFCD29904539
MOL File:
164991-67-7.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-08-02 18:55:13
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KukoaMine B Properties

Boiling point 844.3±65.0 °C(Predicted)
Density 1.232±0.06 g/cm3 (20 ºC 760 Torr)
storage temp. -20°C
solubility DMF:30.0(Max Conc. mg/mL);56.53(Max Conc. mM)
DMSO:30.0(Max Conc. mg/mL);56.53(Max Conc. mM)
Ethanol:30.0(Max Conc. mg/mL);56.53(Max Conc. mM)
PBS (pH 7.2):10.0(Max Conc. mg/mL);18.84(Max Conc. mM)
Water:62.5(Max Conc. mg/mL);117.78(Max Conc. mM)
form A crystalline solid
pka 9.78±0.10(Predicted)
color White to off-white
Major Application food and beverages
InChIKey IWRAOCFRRTWUDF-UHFFFAOYSA-N
SMILES C1(CCC(N(CCCN)CCCCNCCCNC(=O)CCC2=CC=C(O)C(O)=C2)=O)=CC=C(O)C(O)=C1
FDA UNII XZE94LC57W
UNSPSC Code 41116107
NACRES NA.24

SAFETY

Risk and Safety Statements

WGK Germany  WGK 3
Storage Class 11 - Combustible Solids

KukoaMine B price More Price(38)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 21091 Kukoamine B ≥95% 164991-67-7 1mg $40 2026-04-30 Buy
Cayman Chemical 21091 Kukoamine B ≥95% 164991-67-7 5mg $132 2026-04-30 Buy
Cayman Chemical 21091 Kukoamine B ≥95% 164991-67-7 10mg $207 2026-04-30 Buy
Cayman Chemical 21091 Kukoamine B ≥95% 164991-67-7 25mg $423 2026-04-30 Buy
Usbiological 300535 Kukoamine B ≥98% 164991-67-7 10mg $490 2026-06-03 Buy
Product number Packaging Price Buy
21091 1mg $40 Buy
21091 5mg $132 Buy
21091 10mg $207 Buy
21091 25mg $423 Buy
300535 10mg $490 Buy

KukoaMine B Chemical Properties, Uses, Production

Chemical Properties

White crystalline powder, soluble in organic solvents such as methanol, ethanol, DMSO, etc., derived from the bark of Lycium bark.

Uses

Kukoamine B is an amide alkaloiad used in the protection against NMDA-induced neurotoxicity and potential harmful mechanisms. In addition it is seen to inhibit the inflammatory response in the livers of septic mice.

Definition

ChEBI: Kukoamine B is an amine.

in vivo

Kukoamine B (20, 50 mg/kg, i.g., daily, 9 weeks) reduces inflammation and blood glucose without body weight gain or liver mass increase[1].
Kukoamine B (2, 5 mg/kg, p.o., daily, 12 weeks) demonstrates the anti-osteoporotic effects in ovariectomized (OVX) mice[3].
Kukoamine B (1.25-60 mg/kg, i.v., only one injection or very 8 h for 3 days) protects mice challenged with E. coli and reduces the circulatory levels of LPS and TNF-a in sepsis model mice[4].

Animal Model:Male, 4-week old db/db mice (BKS.Cgm+/+Leprdb/J) and wildtype (WT) mice (C57BLKS/J-m+/+ db). A spontaneous type 2 diabetic animal model[1].
Dosage:20, 50 mg/kg
Administration: i.g., daily, 9 weeks
Result:Successfully controlled the augment of blood glucose with age increase.
Reduced levels of 29 inflammatory markers such as IL-2, IL-3, IL-4, IL-5, IL-6, IL-7 and IL8.
Animal Model:Seven-week-old female ddy mice underwent either an ovariectomy or sham-operated surgery[3].
Dosage: 2, 5 mg/kg
Administration: p.o., daily, 12 weeks
Result:Inhibited the OVX-induced BMD loss in the right femur bone and restored the impaired bone structural properties of BV/TV, Tb.Th, Tb.N, and Tb.Sp.
Animal Model:Kunming (KM) mice, 4–6 weeks old, 18–20 g, male and female in equal number. Mice were injected with heat-killed E. coli (EC, 1.0 * 1011 CFUkg-1) in order to establish the sepsis model.[4].
Dosage: 1.25, 2.5, 5, 10, 15, 30, 60 mg/kg
Administration: 80 mice (15, 30, 60 mg/kg), i.v., only one injection; 100 mice (1.25, 2.5, 5 mg/kg), i.v., every 8 h for 3 days; 96 mice, (60 mg/kg), i.v., once at 0, 2, 4, 6, 8 h after injection of EC.
Result:Significantly decreased the mortality rate from 87.5% to 62.5%, 62.5%, or 37.5% (15, 30, 60 mg/kg).
Decreased the mortality rate from 95% to 65%, 60% and 45% (1.25, 2.5 and 5 mg/kg).
Decreased the circulatory LPS and TNF-a levels in a time-dependent manner.

KukoaMine B Preparation Products And Raw materials

Raw materials

Preparation Products

KukoaMine B Suppliers

Global Suppliers ( 156)
Supplier Tel Email Country ProdList Advantage
Jiangxi Baicaoyuan Biotechnology Co. , Ltd. 0791-82165230 17707911324 1459265273@qq.com China 1387 58
Chembest Research Laboratories Limited 021-20908456 sales@BioChemBest.com China 5996 61
Chengdu Biopurify Phytochemicals Ltd. +86-028-82633397 18982077548 cwb1@biopurify.cn China 2376 60
Shanghai Tauto Biotech Co., Ltd. 021-51320588 tauto@tautobiotech.com China 3984 66
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
Quality Control Solutions Ltd. 0755-66853366 13670046396 orders@qcsrm.com China 18188 56
Wuxi Zhongkun Biochemical Technology Co., Ltd. 0510-85629785 18013409632; sales@reading-chemicals.com China 15165 58
Shanghai Aspire Biological Technology Co., Ltd. 021-61317773 sales@aspirebio.com China 2880 58
Shanghai Macklin Biochemical Co.,Ltd. 15221275939 15221275939 shenlinxing@macklin.cn China 15775 55
Shanghai Yongye Biotechnology Co., Ltd. 86-021-61559134 15921386130 3423497944@qq.com China 8135 55
Supplier Advantage
Jiangxi Baicaoyuan Biotechnology Co. , Ltd. 58
Chembest Research Laboratories Limited 61
Chengdu Biopurify Phytochemicals Ltd. 60
Shanghai Tauto Biotech Co., Ltd. 66
Bide Pharmatech Ltd. 60
Quality Control Solutions Ltd. 56
Wuxi Zhongkun Biochemical Technology Co., Ltd. 58
Shanghai Aspire Biological Technology Co., Ltd. 58
Shanghai Macklin Biochemical Co.,Ltd. 55
Shanghai Yongye Biotechnology Co., Ltd. 55

View Latest Price from KukoaMine B manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
KukoaMine B pictures 2026-07-31 KukoaMine B
164991-67-7
 $35.00-129.00 99.59% 10g TargetMol Chemicals Inc.
Kukoamine B pictures 2020-01-19 Kukoamine B
164991-67-7
 $3.00 1KG 99% 1kg,5kg,50kg Career Henan Chemical Co
  • KukoaMine B pictures
  • KukoaMine B
    164991-67-7
  • $35.00-129.00
  • 99.59%
  • TargetMol Chemicals Inc.
  • Kukoamine B pictures
  • Kukoamine B
    164991-67-7
  • $3.00
  • 99%
  • Career Henan Chemical Co

KukoaMine B Spectrum

KukoaMine B(164991-67-7)1HNMR

164991-67-7 (KukoaMine B) Related Search:

Cevadine veratramine SCHIZANDRIN B Scutellarin menisdaurin
VERATRIDINE daurisoline L-Hyoscyamine Xanthiazone 2-[2-(Methylamino)benzoyl]-3,4-dihydro-β-carboline-1(2H)-one
Xanthiside kukoamine A Daurinoline

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KukoaMine B Benzenepropanamide,N-(3-aminopropyl)-N-[4-[[3-[[3-(3,4-dihydroxyphenyl)-1-oxopropyl]amino]propyl]amino]butyl]-3,4-dihydroxy- Kukoamine B-D8 Dihydroxybenzenepropanamide N-(3-Aminopropyl)-3-(3,4-dihydroxyphenyl)-N-(4-((3-(3-(3,4-dihydroxyphenyl)propanamido)propyl)amino)butyl)propanamide Geoscutin Resorcinol Impurity 30 KukoaMine B (Standard) Kukoamine B DiHCl 164991-67-7