GSK-3 Inhibitor X
- CAS No.
- 740841-15-0
- Chemical Name:
- GSK-3 Inhibitor X
- Synonyms
- (E/Z)-BIO-acetoxime;GSK-3 Inhibitor X - CAS 740841-15-0 - Calbiochem;2H-Indol-2-one, 3-[3-[(acetyloxy)imino]-1,3-dihydro-2H-indol-2-ylidene]-6-bromo-1,3-dihydro-
- CBNumber:
- CB82602842
- Molecular Formula:
- C18H12BrN3O3
- Molecular Weight:
- 398.21
- MDL Number:
- MOL File:
- 740841-15-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H341 | |||||||||
| Precautionary statements | P201-P202-P280-P308+P313-P405-P501a | |||||||||
| WGK Germany | WGK 1 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
GSK-3 Inhibitor X price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 361551 | GSK-3 Inhibitor X - CAS 740841-15-0 - Calbiochem | 740841-15-0 | 1mg | $190 | 2026-04-30 | Buy |
| Cayman Chemical | 16329 | BIO-Acetoxime ≥95% | 740841-15-0 | 1mg | $36 | 2026-04-30 | Buy |
| Cayman Chemical | 16329 | BIO-Acetoxime ≥95% | 740841-15-0 | 5mg | $153 | 2026-04-30 | Buy |
| Cayman Chemical | 16329 | BIO-Acetoxime ≥95% | 740841-15-0 | 10mg | $268 | 2026-04-30 | Buy |
| Biosynth | QEB84115 | GSK-3 Inhibitor X | 740841-15-0 | 5mg | $877.05 | 2026-06-04 | Buy |
GSK-3 Inhibitor X Chemical Properties, Uses, Production
Uses
(E/Z)-BIO-acetoxime (GSK-3 Inhibitor X) is a potent and selective GSK-3α/β inhibitor, with an IC50 of 10 nM. (E/Z)-BIO-acetoxime shows more than 200-flod selectivity over CDK5/p25, CDK2/cyclin A and CDK1/cyclin B (IC50=2.4, 4.3, 63 μM)[1].
General Description
An acetoxime analog of BIO, GSK-3 Inhibitor IX (Cat. No. 361550) that exhibits greater selectivity for GSK-3α/β (IC50 = 10 nM) over Cdk5/p25, Cdk2/cyclin A, and Cdk1/cyclin B (IC50 = 2.4 μM, 4.3 μM, and 63 μM, respectively). A weak inhibitor of Cdk4/cyclin D1 and many other non-related kinases (IC50 ≥ 10 μM). Yields BIO (Cat. No. 361550) upon hydrolysis.
Biochem/physiol Actions
Product does not compete with ATP.
IC 50
GSK-3α: 10 nM (IC50); GSK-3β: 10 nM (IC50); Cdk5/p25: 2.4 μM (IC50); CDK2/cyclinA: 4.3 μM (IC50); CDK1/cyclinB: 63 μM (IC50)
References
[1] Meijer L, et, al. GSK-3-selective inhibitors derived from Tyrian purple indirubins. Chem Biol. 2003 Dec;10(12):1255-66. DOI:10.1016/j.chembiol.2003.11.010
GSK-3 Inhibitor X Preparation Products And Raw materials
Raw materials
Preparation Products
GSK-3 Inhibitor X Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| VDM Biochemicals | 0330-2528181 | sales@vdmbio.com | United States | 510 | 64 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD | 13816107857 | sales@fortunechem-sh.com | China | 981 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| D&C Chemicals | +86-21-58447131 | 1724405207@qq.com | China | 470 | 55 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| Changzhou Chenhong Biotechnology Co., Ltd. | +86-0519-85788828 +86-13775037613 | sales@chemrenpharm.com | China | 4058 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| Shanghai Shengkun Biomedical Co., Ltd. | 15065661979 15065661979 | stonebiopharm@163.com | China | 1524 | 58 |
