| Identification | Back Directory | [Name]
GSK-3 Inhibitor X | [CAS]
740841-15-0 | [Synonyms]
(E/Z)-BIO-acetoxime
GSK-3 Inhibitor X - CAS 740841-15-0 - Calbiochem
2H-Indol-2-one, 3-[3-[(acetyloxy)imino]-1,3-dihydro-2H-indol-2-ylidene]-6-bromo-1,3-dihydro- | [Molecular Formula]
C18H12BrN3O3 | [MOL File]
740841-15-0.mol | [Molecular Weight]
398.21 |
| Chemical Properties | Back Directory | [storage temp. ]
+2C to +8C | [solubility ]
DMF: 10 mg/ml; DMSO: 10 mg/ml | [form ]
Dark purple solid | [color ]
dark purple | [Sensitive ]
Light Sensitive |
| Hazard Information | Back Directory | [Uses]
(E/Z)-BIO-acetoxime (GSK-3 Inhibitor X) is a potent and selective GSK-3α/β inhibitor, with an IC50 of 10 nM. (E/Z)-BIO-acetoxime shows more than 200-flod selectivity over CDK5/p25, CDK2/cyclin A and CDK1/cyclin B (IC50=2.4, 4.3, 63 μM)[1]. | [General Description]
An acetoxime analog of BIO, GSK-3 Inhibitor IX (Cat. No. 361550) that exhibits greater selectivity for GSK-3α/β (IC50 = 10 nM) over Cdk5/p25, Cdk2/cyclin A, and Cdk1/cyclin B (IC50 = 2.4 μM, 4.3 μM, and 63 μM, respectively). A weak inhibitor of Cdk4/cyclin D1 and many other non-related kinases (IC50 ≥ 10 μM). Yields BIO (Cat. No. 361550) upon hydrolysis. | [Biochem/physiol Actions]
Product does not compete with ATP. | [IC 50]
GSK-3α: 10 nM (IC50); GSK-3β: 10 nM (IC50); Cdk5/p25: 2.4 μM (IC50); CDK2/cyclinA: 4.3 μM (IC50); CDK1/cyclinB: 63 μM (IC50) | [References]
[1] Meijer L, et, al. GSK-3-selective inhibitors derived from Tyrian purple indirubins. Chem Biol. 2003 Dec;10(12):1255-66. DOI:10.1016/j.chembiol.2003.11.010 |
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BOC Sciences
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Sigma-Aldrich
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D&C Chemicals
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Merck Millipore
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Creative Enzymes
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