1-(4-fluorophenyl)-6-Methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid
- CAS No.
- 888721-65-1
- Chemical Name:
- 1-(4-fluorophenyl)-6-Methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid
- Synonyms
- 1-(4-fluorophenyl)-6-Methyl-2-oxo-1,2-dihydropyridine;1-(4-fluorophenyl)-6-methyl-2-oxopyridine-3-carboxylic acid;1-(4-fluorophenyl)-6-Methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid;3-Pyridinecarboxylic acid, 1-(4-fluorophenyl)-1,2-dihydro-6-methyl-2-oxo-
- CBNumber:
- CB82609351
- Molecular Formula:
- C13H10FNO3
- Molecular Weight:
- 247.22
- MDL Number:
- MFCD12546365
- MOL File:
- 888721-65-1.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
1-(4-fluorophenyl)-6-Methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Matrix Scientific | 310781 | 1-(4-Fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid | 888721-65-1 | 250.00mg | $69 | 2026-05-19 | Buy |
| Matrix Scientific | 310781 | 1-(4-Fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid | 888721-65-1 | 1.00g | $171 | 2026-05-19 | Buy |
| Matrix Scientific | 310781 | 1-(4-Fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid | 888721-65-1 | 5.00g | $506 | 2026-05-19 | Buy |
| Synthonix | F26220 | 1-(4-Fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid 97% | 888721-65-1 | 100mg | $68 | 2026-05-06 | Buy |
| Synthonix | F26220 | 1-(4-Fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid 97% | 888721-65-1 | 250mg | $80 | 2026-05-06 | Buy |
1-(4-fluorophenyl)-6-Methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid Chemical Properties, Uses, Production
Synthesis
104330-60-1
51731-17-0
888721-65-1
General procedure for the preparation of 1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid: to a 4-necked, 3L round-bottomed flask were added ethanol (1500 mL), ethyl 3-((4-fluorophenyl)amino)-3-oxopropanoate (139 g, 617 mmol), sodium ethoxide (65.6 g, 925 mmol), and trans-4-methoxy-3 -buten-2-one (103 g, 925 mmol). The reaction mixture was refluxed for 3 hours. Upon completion of the reaction, the solution was cooled to room temperature and subsequently concentrated under reduced pressure to remove ethanol. The residue was diluted with dichloromethane (700 mL) and 1 M hydrochloric acid (1500 mL). The aqueous phase was extracted with dichloromethane (3 x 500 mL). The organic extracts were combined, washed with saturated aqueous sodium chloride (1000 mL), dried over anhydrous sodium sulfate and subsequently concentrated under reduced pressure. The residue was ground with ethyl acetate (150 mL) for 1 hour at room temperature (10-15°C). After filtration and washing with ethyl acetate (50 mL), 1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid was obtained as a yellow solid (85.3 g, 56% yield). Mass spectrum (m/z): 248 (M + H).
References
[1] Patent: US2010/22529, 2010, A1. Location in patent: Page/Page column 18
1-(4-fluorophenyl)-6-Methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid Preparation Products And Raw materials
Raw materials
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Preparation Products
1-(4-fluorophenyl)-6-Methyl-2-oxo-1,2-dihydropyridine-3-carboxylic acid Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
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