JTC-801
- CAS No.
- 244218-93-7
- Chemical Name:
- JTC-801
- Synonyms
- JTC-801 free base;JTC801 free base,JTC 801 free base;N-(4-amino-2-methyl-6-quinolinyl)-2-[(4-ethylphenoxy)methyl]Benzamide;Benzamide, N-(4-amino-2-methyl-6-quinolinyl)-2-[(4-ethylphenoxy)methyl]-
- CBNumber:
- CB82646574
- Molecular Formula:
- C26H25N3O2
- Molecular Weight:
- 411.5
- MDL Number:
- MFCD08272156
- MOL File:
- 244218-93-7.mol
- MSDS File:
- SDS
| Melting point | >300 °C(Solv: ethanol (64-17-5)) |
|---|---|
| Boiling point | 580.9±50.0 °C(Predicted) |
| Density | 1.240±0.06 g/cm3(Predicted) |
| pka | 13.27±0.43(Predicted) |
| FDA UNII | BXU45ZH6LI |
JTC-801 Chemical Properties, Uses, Production
Uses
JTC-801 free base is a selective opioid receptor-like1 (ORL1) receptor antagonist, binding to ORL1 receptor with a Ki value of 8.2nM.
Definition
ChEBI: N-(4-amino-2-methyl-6-quinolinyl)-2-[(4-ethylphenoxy)methyl]benzamide is an aminoquinoline.
References
[1] Koyama T, et al. Nociceptin receptor antagonist JTC-801 inhibits nitrous oxide-induced analgesia in mice. J Anesth. 2009;23(2):301-3. DOI:10.1007/s00540-009-0739-2
[2] Yamada H, et al. Pharmacological profiles of a novel opioid receptor-like1 (ORL(1)) receptor antagonist, JTC-801. Br J Pharmacol, 2002, 135(2), 323-332. DOI:10.1038/sj.bjp.0704478
[3] Shinkai H, et al. 4-Aminoquinolines: novel nociceptin antagonists with analgesic activity. J Med Chem, 2000, 43(24), 4667-4677. DOI:10.1021/jm0002073
[4] Zhang Y, et al. Nociceptin/orphanin FQ peptide receptor antagonist JTC-801 reverses pain and anxiety symptoms in a rat model of post-traumatic stress disorder. Br J Pharmacol. 2015 Jan;172(2):571-82. DOI:10.1111/bph.12701
JTC-801 Preparation Products And Raw materials
Raw materials
Preparation Products
JTC-801 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Kebele Pharmaceutical R&D Co., Ltd | 13119135307 | 3866620171@qq.com | China | 2657 | 58 |
| NCE Biomedical Co.,Ltd. | 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 | China | 1490 | 55 | |
| SPIRO PHARMA | eric_feng1954@126.com | China | 313 | 55 | |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6378 | 58 |
| Hefei fuya biotechnology co. LTD | 18096409024 | sales02@foreversyn.com | China | 1934 | 58 |
| Chunchuang (Wuhan) Technology Co., Ltd | 15727060112 | yutianchun2007@126.com | China | 9867 | 58 |
| ChengDu SinoStandards Bio-Tech Co.,Ltd. ， | 028-83243028 19136088901 | sinostandards@163.com | China | 4979 | 58 |
| InvivoChem | 13549236410 | sales@invivochem.cn | China | 6745 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Shanghai Easy CDMO Co.,Ltd | Info@easycdmo.com 13564957716 | Info@easycdmo.com | China | 9999 | 58 |
View Latest Price from JTC-801 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-21 | JTC-801 free base
244218-93-7
|
$1520.00-2500.00 | 10g | TargetMol Chemicals Inc. |
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- JTC-801 free base
244218-93-7
- $1520.00-2500.00
- TargetMol Chemicals Inc.
