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| | JTC-801 Basic information |
| Product Name: | JTC-801 | | Synonyms: | N-(4-amino-2-methyl-6-quinolinyl)-2-[(4-ethylphenoxy)methyl]Benzamide;Benzamide, N-(4-amino-2-methyl-6-quinolinyl)-2-[(4-ethylphenoxy)methyl]-;JTC801 free base,JTC 801 free base;JTC-801 free base | | CAS: | 244218-93-7 | | MF: | C26H25N3O2 | | MW: | 411.5 | | EINECS: | | | Product Categories: | | | Mol File: | 244218-93-7.mol |  |
| | JTC-801 Chemical Properties |
| Melting point | >300 °C(Solv: ethanol (64-17-5)) | | Boiling point | 580.9±50.0 °C(Predicted) | | density | 1.240±0.06 g/cm3(Predicted) | | pka | 13.27±0.43(Predicted) |
| | JTC-801 Usage And Synthesis |
| Uses | JTC-801 free base is a selective opioid receptor-like1 (ORL1) receptor antagonist, binding to ORL1 receptor with a Ki value of 8.2nM. | | Definition | ChEBI: N-(4-amino-2-methyl-6-quinolinyl)-2-[(4-ethylphenoxy)methyl]benzamide is an aminoquinoline. | | References | [1] Koyama T, et al. Nociceptin receptor antagonist JTC-801 inhibits nitrous oxide-induced analgesia in mice. J Anesth. 2009;23(2):301-3. DOI:10.1007/s00540-009-0739-2
[2] Yamada H, et al. Pharmacological profiles of a novel opioid receptor-like1 (ORL(1)) receptor antagonist, JTC-801. Br J Pharmacol, 2002, 135(2), 323-332. DOI:10.1038/sj.bjp.0704478
[3] Shinkai H, et al. 4-Aminoquinolines: novel nociceptin antagonists with analgesic activity. J Med Chem, 2000, 43(24), 4667-4677. DOI:10.1021/jm0002073
[4] Zhang Y, et al. Nociceptin/orphanin FQ peptide receptor antagonist JTC-801 reverses pain and anxiety symptoms in a rat model of post-traumatic stress disorder. Br J Pharmacol. 2015 Jan;172(2):571-82. DOI:10.1111/bph.12701 |
| | JTC-801 Preparation Products And Raw materials |
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