2-IODO-5-NITROBENZOIC ACID
- CAS No.
- 19230-50-3
- Chemical Name:
- 2-IODO-5-NITROBENZOIC ACID
- Synonyms
- 2-IODO-5-NITROBENZOIC ACID;Benzoic acid,2-iodo-5-nitro-
- CBNumber:
- CB8300881
- Molecular Formula:
- C7H4INO4
- Molecular Weight:
- 293.02
- MDL Number:
- MFCD00234256
- MOL File:
- 19230-50-3.mol
- MSDS File:
- SDS
| Melting point | 197-198 °C |
|---|---|
| Boiling point | 394.2±37.0 °C(Predicted) |
| Density | 2.156±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| pka | 2.16±0.10(Predicted) |
| Appearance | White to yellow Solid |
| InChI | InChI=1S/C7H4INO4/c8-6-2-1-4(9(12)13)3-5(6)7(10)11/h1-3H,(H,10,11) |
| InChIKey | JSSFIFUXHORXJX-UHFFFAOYSA-N |
| SMILES | C(O)(=O)C1=CC([N+]([O-])=O)=CC=C1I |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
2-IODO-5-NITROBENZOIC ACID price More Price(33)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | I706415 | 2-Iodo-5-nitrobenzoicAcid | 19230-50-3 | 100mg | $60 | 2021-12-16 | Buy |
| AK Scientific | X8087 | 2-Iodo-5-nitrobenzoicacid | 19230-50-3 | 5g | $296 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | HCH0055120 | 2-IODO-5-NITROBENZOIC ACID 95.00% | 19230-50-3 | 1G | $353.85 | 2021-12-16 | Buy |
| AK Scientific | X8087 | 2-Iodo-5-nitrobenzoicacid | 19230-50-3 | 1g | $154 | 2021-12-16 | Buy |
| AK Scientific | X8087 | 2-Iodo-5-nitrobenzoicacid | 19230-50-3 | 10g | $451 | 2021-12-16 | Buy |
2-IODO-5-NITROBENZOIC ACID Chemical Properties,Uses,Production
Uses
2-iodo-5-nitrobenzoic acid is a useful reactant for the synthesis of 2-?Arylquinazolines and Tetracyclic Isoindolo[1,?2-?a]?quinazoline.
Synthesis
88-67-5
19230-50-3
During this preparation, up to 25 mmol of I2 is generated. therefore, the synthesis operation must be carried out in a well-ventilated fume hood. The preparation was carried out with reference to the literature method [10]. 2-Iodobenzoic acid (4.10 g, 40.3 mmol, 1 equiv) was added to a mixed solution of HNO3 (35 mL, 65%) and H2SO4 (85 mL, 95%). The reaction mixture was heated to 135 °C and stirred at this temperature for 1 hour. Upon completion of the reaction, the resulting brown slurry was poured on ice, filtered to collect the gray precipitate, and washed with plenty of water. Subsequently, the filter cake was suspended in water (100 mL), heated to 100 °C and a solution consisting of KI (8.5 g, 51.2 mmol, 1.3 eq.) and H2SO4 (5 drops) dissolved in water (10 mL) was added in the process and the reaction was continued for 1 hour. Finally, the brown suspension was filtered while hot and washed with cold water to give the pure product 2-iodo-5-nitrobenzoic acid (5 g, 42% yield) as a brown solid. If the product is impure, it can be purified by boiling in water and then hot filtering.
References
[1] Journal of Organic Chemistry, 2005, vol. 70, # 12, p. 4778 - 4783
[2] Synlett, 2013, vol. 24, # 13, p. 1707 - 1711
[3] Beilstein Journal of Organic Chemistry, 2014, vol. 10, p. 1 - 6
[4] Organic Letters, 2011, vol. 13, # 3, p. 518 - 521
[5] Helvetica Chimica Acta, 1930, vol. 13, p. 310,311
2-IODO-5-NITROBENZOIC ACID Preparation Products And Raw materials
Raw materials
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Preparation Products
2-IODO-5-NITROBENZOIC ACID Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-0519-85551759 +8613506123987 | marketing1@neostarunited.com | China | 8829 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30229 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Wuhan Demeikai Biotechnology Co., Ltd | +8618942921723 | info@dmksw.xin | China | 717 | 58 |
| Aromsyn Co., Ltd. | +86-0571-85585865 +8613336024896 | CB@aromsyn.com | China | 19183 | 58 |
| Aceschem Inc. | +1-817863-6948 +1-（817）863-6948 | sales@aceschem.com | United States | 19632 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| DAYANG CHEM (HANGZHOU) CO.,LTD | +86-88938639 +86-17705817739 | info@dycnchem.com | China | 53900 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
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