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NS-018

NS-018 structure

CAS No.: 1239358-86-1

Chemical Name:: NS-018

Synonyms: Ilginatinib;NS-018;NS018;ILGINATINIB;ILGINATINIB (NS-018);Ilginatinib, 10 mM in DMSO;JAK3,Janus kinase,Inhibitor,NS 018,JAK,JAK2,orally,Tyk2,NS018,Ilginatinib,inhibit,JAK1,bioavailable;2,6-Pyridinediamine, N2-[(1S)-1-(4-fluorophenyl)ethyl]-4-(1-methyl-1H-pyrazol-4-yl)-N6-2-pyrazinyl-;N2-[(1S)-1-(4-fluorophenyl)ethyl]-4-(1-methyl-1H-pyrazol-4-yl)-N6-(pyrazin-2-yl)pyridine-2,6-diamine

CBNumber:: CB83067013

Molecular Formula:: C21H20FN7

Molecular Weight:: 389.43

MDL Number:: MFCD28502056

MOL File:: 1239358-86-1.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-07-27 17:00:41

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NS-018 Properties

Boiling point	574.1±50.0 °C(Predicted)
Density	1.31±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO : ≥ 34 mg/mL (87.31 mM)
form	Solid
pka	2.43±0.10(Predicted)
color	Light yellow to yellow
FDA UNII	56R994WX4L
NCI Drug Dictionary	ilginatinib

NS-018 price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Biosynth	PZB35886	Ilginatinib	1239358-86-1	10mg	$662.7	2026-06-04	Buy
Biosynth	PZB35886	Ilginatinib	1239358-86-1	25mg	$1242.5	2026-06-04	Buy
Biosynth	PZB35886	Ilginatinib	1239358-86-1	50mg	$1988.5	2026-06-04	Buy
ChemScene	CS-5358	Ilginatinib 99.94%	1239358-86-1	1mg	$106	2026-06-04	Buy
ChemScene	CS-5358	Ilginatinib 99.94%	1239358-86-1	5mg	$213	2026-06-04	Buy

Product number	Packaging	Price	Buy
PZB35886	10mg	$662.7	Buy
PZB35886	25mg	$1242.5	Buy
PZB35886	50mg	$1988.5	Buy
CS-5358	1mg	$106	Buy
CS-5358	5mg	$213	Buy

NS-018 Chemical Properties,Uses,Production

Uses

Ilginatinib (NS-018) is a highly active and orally bioavailable JAK2 inhibitor, with an IC50 of 0.72 nM, 46-, 54-, and 31-fold selectivity for JAK2 over JAK1 (IC50, 33 nM), JAK3 (IC50, 39 nM), and Tyk2 (IC50, 22 nM).

in vivo

Ilginatinib (NS-018) (12.5, 25, 50, 100 mg/kg, p.o.) potently prolongs the survival of mice and reduces splenomegaly in a mouse Ba/F3-JAK2V617F disease model^[1].
Ilginatinib (NS-018) (25, 50 mg/kg, p.o.) significantly reduces leukocytosis, hepatosplenomegaly and extramedullary hematopoiesis, improves nutritional status, and prolongs survival in JAK2V617F transgenic mice

IC 50

JAK2: 0.72 nM (IC₅₀); Tyk2: 22 nM (IC₅₀); JAK1: 33 nM (IC₅₀); JAK3: 39 nM (IC₅₀)

References

[1] Nakaya Y, et al. Efficacy of NS-018, a potent and selective JAK2/Src inhibitor, in primary cells and mouse models of myeloproliferative neoplasms. Blood Cancer J. 2011 Jul;1(7):e29. DOI:10.1038/bcj.2011.29
[2] Kuroda J, et al. NS-018, a selective JAK2 inhibitor, preferentially inhibits CFU-GM colony formation by bone marrow mononuclear cells from high-risk myelodysplastic syndrome patients. Leuk Res. 2014 May;38(5):619-24. DOI:10.1016/j.leukres.2014.03.001

NS-018 Preparation Products And Raw materials

Raw materials

Preparation Products

NS-018 Suppliers

Global( 42)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
BOC Sciences	1-631-485-4226; 16314854226	info@bocsci.com	United States	9920	65
Haoyuan Chemexpress Co., Ltd.	021-58950125	info@chemexpress.com	China	7545	61
MedChemexpress LLC	021-58955995	sales@medchemexpress.cn	United States	4853	58
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4861	55
Shanghai YuanYe Biotechnology Co., Ltd.	15026964105	2881489226@qq.com	China	89667	60
ShangHai Biochempartner Co.,Ltd	177-54423994 17754423994	2853530910@QQ.com	China	8000	62
Shanghai Rechem science Co., Ltd.	021-31433387 15618786686	sales@rechemscience.com	China	2971	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131885	58
Musechem	+1-800-259-7612	info@musechem.com	United States	4648	60
Angel Pharmatech, Ltd.	17317130613	3358272972@qq.com	China	3307	58

Supplier	Advantage
BOC Sciences	65
Haoyuan Chemexpress Co., Ltd.	61
MedChemexpress LLC	58
Shanghai Lollane Biological Technology Co.,Ltd.	55
Shanghai YuanYe Biotechnology Co., Ltd.	60
ShangHai Biochempartner Co.,Ltd	62
Shanghai Rechem science Co., Ltd.	58
Amadis Chemical Company Limited	58
Musechem	60
Angel Pharmatech, Ltd.	58

View Lastest Price from NS-018 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-07-27	Ilginatinib 1239358-86-1	$58.00-196.00		98.40%	10g	TargetMol Chemicals Inc.
	2026-07-27	Ilginatinib 1239358-86-1	$58.00-196.00		98.40%	10g	TargetMol Chemicals Inc.

Ilginatinib
1239358-86-1
$58.00-196.00
98.40%
TargetMol Chemicals Inc.

Ilginatinib
1239358-86-1
$58.00-196.00
98.40%
TargetMol Chemicals Inc.

NS-018 Spectrum

NS-018(1239358-86-1)¹HNMR

1239358-86-1(NS-018)Related Search:

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Anti-Aging Compound Library

1of2

N2-[(1S)-1-(4-fluorophenyl)ethyl]-4-(1-methyl-1H-pyrazol-4-yl)-N6-(pyrazin-2-yl)pyridine-2,6-diamine NS018;ILGINATINIB ILGINATINIB (NS-018) NS-018 2,6-Pyridinediamine, N2-[(1S)-1-(4-fluorophenyl)ethyl]-4-(1-methyl-1H-pyrazol-4-yl)-N6-2-pyrazinyl- JAK3,Janus kinase,Inhibitor,NS 018,JAK,JAK2,orally,Tyk2,NS018,Ilginatinib,inhibit,JAK1,bioavailable Ilginatinib, 10 mM in DMSO Ilginatinib 1239358-86-1 C21H20FN7