k-80003
- CAS No.
- 1292821-90-9
- Chemical Name:
- k-80003
- Synonyms
- TX-803;k-80003;K 80003,K80003;K-80003 (TX-803);K-80003, 10 mM in DMSO;1H-Indene-3-acetic acid, 5-fluoro-2-methyl-1-[[4-(1-methylethyl)phenyl]methylene]-, (1Z)-
- CBNumber:
- CB83171477
- Molecular Formula:
- C22H21FO2
- Molecular Weight:
- 336.4
- MDL Number:
- MFCD31619327
- MOL File:
- 1292821-90-9.mol
- MSDS File:
- SDS
| Boiling point | 491.6±40.0 °C(Predicted) |
|---|---|
| Density | 1.192±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO: 30 mg/mL (89.18 mM) |
| pka | 4.27±0.10(Predicted) |
| form | Solid |
| color | Light yellow to yellow |
| FDA UNII | 4S7931G4PP |
k-80003 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0039348 | K-80003 98.83% | 1292821-90-9 | 5mg | $141 | 2026-06-04 | Buy |
| ChemScene | CS-0039348 | K-80003 98.83% | 1292821-90-9 | 10mg | $225 | 2026-06-04 | Buy |
| ChemScene | CS-0039348 | K-80003 98.83% | 1292821-90-9 | 50mg | $650 | 2026-06-04 | Buy |
| aablocks | AA01EO7C | K-80003 | 1292821-90-9 | 2mg | $51 | 2026-05-30 | Buy |
| aablocks | AA01EO7C | K-80003 | 1292821-90-9 | 5mg | $72 | 2026-05-30 | Buy |
k-80003 Chemical Properties, Uses, Production
Uses
K-80003 is a potent inhibitor of tRXRα-dependent Akt activation and cancer cell growth.
Definition
ChEBI: [5-fluoro-1-(4-isopropylbenzylidene)-2-methylinden-3-yl]acetic acid is a sulindac-based non-steroidal anti-inflammatory drug. It has a role as a non-steroidal anti-inflammatory drug. It is functionally related to an acetic acid.
in vivo
K-80003 is a potent inhibitor of AKT activation by all-trans-retinoic acid. K-80003 displays enhanced efficacy in inhibiting tRXRα-dependent AKT activation and tRXRα tumor growth in animals. K-80003 has high affinity to RXRα but lacks COX inhibitory activity[1].
References
[1] Zhou H, et al. NSAID sulindac and its analog bind RXRalpha and inhibit RXRalpha-dependent AKT signaling. Cancer Cell. 2010 Jun 15;17(6):560-73. DOI:10.1016/j.ccr.2010.04.023
[2] Chen L, et al. Modulation of nongenomic activation of PI3K signalling by tetramerization of N-terminally-cleaved RXRα. Nat Commun. 2017 Jul 17;8:16066. DOI:10.1038/ncomms16066
k-80003 Preparation Products And Raw materials
Raw materials
Preparation Products
k-80003 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ChemCell Biomedicine Co.,Ltd. | 020-13556033878 2965585218 13556033878 | chemcell@hotmail.com | China | 369 | 52 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7717 | 56 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| Allbio pharm Co., Ltd | 1483287082 19962651230 | sales@allbiopharm.com | China | 1423 | 58 |
| InvivoChem | 13549236410 | sales@invivochem.cn | China | 6745 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| Shanghai?Medlife?Pharm-Tech?Co.,?Ltd | 4000862158 18117107507 | vip@med-life.cn | China | 4999 | 58 |
