YUKA1
- CAS No.
- 708991-09-7
- Chemical Name:
- YUKA1
- Synonyms
- YUKA1;YUKA1,YUKA-1;3H-1,2,4-Triazole-3-thione, 2,4-dihydro-4-[[[3-methoxy-2-(2-propen-1-yloxy)phenyl]methyl]amino]-
- CBNumber:
- CB83175798
- Molecular Formula:
- C13H16N4O2S
- Molecular Weight:
- 292.36
- MDL Number:
- MFCD04141903
- MOL File:
- 708991-09-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
YUKA1 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | IDB99109 | YUKA1 | 708991-09-7 | 25mg | $1396.5 | 2026-06-04 | Buy |
| Biosynth | IDB99109 | YUKA1 | 708991-09-7 | 50mg | $1943 | 2026-06-04 | Buy |
| Biosynth | IDB99109 | YUKA1 | 708991-09-7 | 100mg | $3110 | 2026-06-04 | Buy |
| ChemScene | CS-0020252 | YUKA1 99.15% | 708991-09-7 | 5mg | $368 | 2026-06-04 | Buy |
| ChemScene | CS-0020252 | YUKA1 99.15% | 708991-09-7 | 10mg | $596 | 2026-06-04 | Buy |
YUKA1 Chemical Properties, Uses, Production
Description
YUKA1 is a cell permeable, potent inhibitor of KDM5A, showing little to no activity against KDM5B, KDM6A, and KDM6B. YUKA1 was shown to increase H3K4me3 levels in human cells and selectively inhibit the proliferation of cancer cells whose growth depends on KDM5A.
Uses
YUKA1 is a potent and cell permeable Lysine demethylase 5A (KDM5A) inhibitor, with an IC50 of 2.66 μM, less active on KDM5C (IC50, 7.12 μM), and is inactive on KDM5B, KDM6A or KDM6B. YUKA1 increases H3K4me3 levels in human cells with anti-cancer activity[1].
IC 50
KDM5
References
[1] Gale M, et al. Screen-identified selective inhibitor of lysine demethylase 5A blocks cancer cell growth and drug resistance. Oncotarget. 2016 Jun 28;7(26):39931-39944. DOI:10.18632/oncotarget.9539
YUKA1 Preparation Products And Raw materials
Raw materials
Preparation Products
YUKA1 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7717 | 56 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9718 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| Shanghai Amole Biotechnology Co., Ltd. | 13370042665 18916960931 | 2596183085@qq.com | China | 17234 | 58 |
| Guangzhou Ruidi Biotechnology Co., Ltd. | 020-82099279 18988941402 | sales@ubiochem.com | China | 10000 | 58 |
| TargetMol Chemicals Inc. | 13564774135 | marketing@targetmol.com | United States | 19950 | 58 |
