Ethyl trifluoropyruvate
- CAS No.
- 13081-18-0
- Chemical Name:
- Ethyl trifluoropyruvate
- Synonyms
- ETHYL 3,3,3-TRIFLUORO-2-OXOPROPANOATE;ETHYL 3,3,3-TRIFLUOROPYRUVATE;E-TFPA;RARECHEM AL BI 1300;ETHYL TRIFLUOROPYRUVATE;3,3,3-Trifluoropyruvate;Ethyltrifluoropyruvate98%;ETHYL 3,3,3-TRIFLUORO-2-O;Threefluorideethylpyruvate;Ethyl trifluoropyruvate 98%
- CBNumber:
- CB8333735
- Molecular Formula:
- C5H5F3O3
- Molecular Weight:
- 170.09
- MDL Number:
- MFCD00114935
- MOL File:
- 13081-18-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 42 °C(lit.) |
|---|---|
| Density | 1.283 g/mL at 25 °C (lit.) |
| vapor pressure | 12.49hPa at 25℃ |
| refractive index |
n |
| Flash point | 88 °F |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | Miscible with dichloromethane. |
| form | Liquid |
| color | Clear colorless to pale yellow |
| BRN | 2087388 |
| Stability | Moisture Sensitive |
| InChI | InChI=1S/C5H5F3O3/c1-2-11-4(10)3(9)5(6,7)8/h2H2,1H3 |
| InChIKey | KJHQVUNUOIEYSV-UHFFFAOYSA-N |
| SMILES | C(OCC)(=O)C(=O)C(F)(F)F |
| LogP | -0.05 |
| CAS DataBase Reference | 13081-18-0(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H226-H302-H315-H319-H335 | |||||||||
| Precautionary statements | P210-P233-P240-P301+P312-P303+P361+P353-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | Eyeshields, Faceshields, Gloves | |||||||||
| Hazard Codes | Xn,C,Xi | |||||||||
| Risk Statements | 10-22-36/37/38 | |||||||||
| Safety Statements | 26-37/39-16 | |||||||||
| RIDADR | UN 3272 3/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Corrosive | |||||||||
| HazardClass | 3 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29183000 | |||||||||
| Storage Class | 3 - Flammable liquids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 Flam. Liq. 3 Skin Irrit. 2 STOT SE 3 |
|||||||||
| REACH Registrations | Active | |||||||||
| Limited Quantities | 5.0 L (1.3 gallons) (liquid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
Ethyl trifluoropyruvate price More Price(59)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 510254 | Ethyl 3,3,3-trifluoropyruvate 97% | 13081-18-0 | 5g | $28.5 | 2026-04-30 | Buy |
| TCI Chemical | T1434 | Ethyl Trifluoropyruvate >98.0%(GC) | 13081-18-0 | 5g | $47 | 2026-04-30 | Buy |
| TCI Chemical | T1434 | Ethyl Trifluoropyruvate >98.0%(GC) | 13081-18-0 | 25g | $135 | 2026-04-30 | Buy |
| Usbiological | 242482 | Trifluoropyruvic Acid Ethyl Ester 99+% (GC) ≥99%(GC) | 13081-18-0 | 5g | $163 | 2026-06-03 | Buy |
| Usbiological | 242482 | Trifluoropyruvic Acid Ethyl Ester 99+% (GC) ≥99%(GC) | 13081-18-0 | 25g | $170 | 2026-06-03 | Buy |
Ethyl trifluoropyruvate Chemical Properties,Uses,Production
Chemical Properties
Clear pale yellow liquid
Uses
Ethyl Trifluoropyruvate is used as a reagent in the preparation of potential biologically active compounds such as in the highly enantioselective organocatalytic hydroxyalkylation of indoles .
Uses
Ethyl trifluoropyruvate acts as a building block in synthetic chemistry for the synthesis of fluorine containing compounds. It is also used as a reagent for the preparation of potential biologically active compounds like highly enantioselective organocatalytic hydroxyalkylation of indoles.
Uses
Ethyl 3,3,3-trifluoropyruvate may be used in the preparation of N-heteroaryl(trifluoromethyl)hydroxyalkanoic acid esters.
General Description
Ethyl 3,3,3-trifluoropyruvate is a trifluoromethylated compound. Enantioselective Friedel–Crafts alkylation of simple phenols and indoles with ethyl 3,3,3-trifluoropyruvate under different reaction conditions have been reported.
Synthesis
To 58 mL (1.0 mL/mmol) of acetonitrile, 10 g (58 mmol, 1.0 eq) of ethyl 3,3,3-trifluorolactate was added and dissolved therein.Furthermore, 11 g (67 mmol, 1.2 eq) of NaClO.5H2O was added, followed by stirring at 20° C. for 30 minutes.As the reaction-terminated liquid was analyzed by 19F-NMR, conversion was 100%, and selectivity was 98%.To the reaction-terminated liquid, 0.38 g (1.5 mmol, 0.026 eq) of sodium thiosulfate pentahydrate was added, followed by stirring, thereby quenching the remaining oxidation agent.Furthermore, 0.33 g (3.9 mmol, 0.067 eq) of sodium hydrogencarbonate and 10 g (70 mmol, 1.2 eq) of sodium sulfate were added, followed by stirring and then removing solid matter by filtration.As the filtrate was quantified with internal standard method (internal standard substance: α,α,α-trifluorotoluene) by 19F-NMR, Ethyl trifluoropyruvate was contained by 56 mmol (quantitative yield: 97%).By a simple distillation (up to 48° C./0.5 kPa) of the filtrate, 7.6 g of Ethyl trifluoropyruvate was obtained. 19F-NMR purity was 99% (40 mmol), and the total yield was 69%.
References
[1] Patent: US2018/50976, 2018, A1. Location in patent: Paragraph 0143; 0144; 0145; 0146; 0147; 0148; 0149; 0150
Ethyl trifluoropyruvate Preparation Products And Raw materials
Raw materials
Preparation Products
1of2
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Sichuan Kulinan Technology Co., Ltd | 400-1166-196 18981987031 | cdhxsj@163.com | China | 11674 | 57 |
| HANGZHOU HETE CHEMICAL TECHNOLOGY CO.,LTD | 571-89189769 15168342188 | China | 228 | 62 | |
| China Synchem Technology Co.,Ltd. | +86-0552-4929304 +86-18055277008 | sales@cnsynchem.com | China | 55 | 65 |
| Hangzhou Cedareal Technology Co., Ltd. | 13858087543 | 368073698@qq.com | China | 46 | 58 |
| GUANGZHOU AANPHARM TECHNOLOGY CO.,LTD | 020-86211473 13925088720 | linda@aanpharm.com | China | 3641 | 58 |
| shanghai sinofluoro chemicals co., ltd. | 15800445152 | sales@sinofluoro.com | China | 298 | 59 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| future industrial shanghai co., ltd | 400-0066400 13621662912 | sales@jonln.com | China | 1989 | 65 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
View Lastest Price from Ethyl trifluoropyruvate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-30 | Ethyl trifluoropyruvate
13081-18-0
|
1KG | 98.0% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2026-05-28 | Ethyl trifluoropyruvate
13081-18-0
|
$9.00 | 1KG | 99.9 | 1 ton | Hebei Chuanghai Biotechnology Co,.LTD | |
 |
2025-04-04 | Ethyl trifluoropyruvate
13081-18-0
|
1KG | 98% | 1ton | Henan Aochuang Chemical Co.,Ltd. |
-
- Ethyl trifluoropyruvate
13081-18-0
- 98.0%
- Shaanxi Dideu New Materials Co. Ltd
-
- Ethyl trifluoropyruvate
13081-18-0
- $9.00
- 99.9
- Hebei Chuanghai Biotechnology Co,.LTD
-
- Ethyl trifluoropyruvate
13081-18-0
- 98%
- Henan Aochuang Chemical Co.,Ltd.
