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WIN 55,212-2 mesylate

WIN 55,212-2 mesylate Structure
WIN 55,212-2 mesylate structure
CAS No.
131543-23-2
Chemical Name:
WIN 55,212-2 mesylate
Synonyms
WIN55;WIN 55,212-2;QLv2;CS-754;212-2Mesylate;WIN552122;WIN-552122;WIN 55,212-2 mesylate;R(+)-WIN 55,212-2 MESYLATE;WIN 55212-2 methanesulfonate;(R)-(+)-WIN 55,212-2 mesylate salt
CBNumber:
CB8335502
Molecular Formula:
C27H26N2O3.CH4O3S
Molecular Weight:
522.61
MDL Number:
MFCD00153882
MOL File:
131543-23-2.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:55:40
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WIN 55,212-2 mesylate Properties

storage temp. Store at +4°C
solubility 0.1 M HCl: 0.25 mg/mL
form solid
pka 4.14
color white to off-white
Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
InChIKey FSGCSTPOPBJYSX-OZYVVJTJNA-N
SMILES S(O)(=O)(=O)C.C(N1CCOCC1)[C@@H]1COC2=CC=CC3C(C(C4=CC=CC5=CC=CC=C45)=O)=C(C)N1C=32 |&1:12,r|
FDA UNII 2J851TP7VJ
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

PPE Eyeshields, Gloves, type N95 (US)
WGK Germany  3
Storage Class 11 - Combustible Solids

WIN 55,212-2 mesylate price More Price(33)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich W102 (R)-(+)-WIN 55,212-2 mesylate salt ≥98% (HPLC) 131543-23-2 25mg $492 2026-04-30 Buy
Sigma-Aldrich W102 (R)-(+)-WIN 55,212-2 mesylate salt ≥98% (HPLC) 131543-23-2 100mg $1000 2026-04-30 Buy
Cayman Chemical 10009023 (+)-WIN 55,212-2 (mesylate) ≥98% 131543-23-2 5mg $65 2026-04-30 Buy
Cayman Chemical 10009023 (+)-WIN 55,212-2 (mesylate) ≥98% 131543-23-2 10mg $124 2026-04-30 Buy
Cayman Chemical 10009023 (+)-WIN 55,212-2 (mesylate) ≥98% 131543-23-2 25mg $277 2026-04-30 Buy
Product number Packaging Price Buy
W102 25mg $492 Buy
W102 100mg $1000 Buy
10009023 5mg $65 Buy
10009023 10mg $124 Buy
10009023 25mg $277 Buy

WIN 55,212-2 mesylate Chemical Properties, Uses, Production

Description

(+)-WIN 55,212-2 (mesylate) is a potent aminoalkylindole cannabinoid (CB) receptor agonist with Ki values of 62.3 and 3.3 nM for human recombinant CB1 and CB2 receptors, respectively. In primary cultures of rat cerebral cortex neurons, (+)-WIN 55,212-2 (mesylate) (0.01-100 nM) increases extracellular glutamate levels, displaying a bell-shaped concentration-response curve. This effect is fully counteracted by rimonabant at a concentration of 10 nM, by decreasing Ca2+ concentrations below 0.2 mM, or by the IP3 receptor antagonist xestospongin C at a concentration of 1 μM. (+)-WIN 55,212-2 (mesylate) induces release of the proinflammatory neuropeptide CGRP from trigeminal ganglion (TG) neurons in a calcium-dependent manner with an EC50 value of 26 μM.

Uses

(R)-(+)-WIN 55,212-2 mesylate salt has been used as a high affinity cannabinoid agonist for intraperitoneal injection into rats to induce behavioural sensitization. It has also been used as a synthetic cannabinoid drug and cannabinoid receptor 1 (CNR1) agonist to treat Becn2+/ mice and wild-type (WT) littermate to analyze the levels of CNR1 in the brain.

General Description

WIN 55,212-2 is a member of the aminoalkylindole class of compounds.

Biological Activity

Nanomolar affinity cannabinoid receptor agonist (K i values are 62.3 and 3.3 nM at the human cloned CB 1 and CB 2 receptors respectively). Also available as part of the Cannabinoid Receptor Agonist Tocriset™ .

Biochem/physiol Actions

It is known to decrease the lipopolysaccharide mediated release of tumor necrosis factor- α and interleukin-1 in mice.

storage

Store at +4°C

References

[1] C C FELDER. Comparison of the pharmacology and signal transduction of the human cannabinoid CB1 and CB2 receptors.[J]. Molecular Pharmacology, 1995, 48 3: 443-450.
[2] U HERZBERG . The analgesic effects of R(+)-WIN 55,212–2 mesylate, a high affinity cannabinoid agonist, in a rat model of neuropathic pain[J]. Neuroscience Letters, 1997, 221 2: Pages 157-160. DOI:10.1016/s0304-3940(96)13308-5
[3] M BOUABOULA. Activation of mitogen-activated protein kinases by stimulation of the central cannabinoid receptor CB1.[J]. Biochemical Journal, 1995, 312 ( Pt 2): 637-641. DOI:10.1042/bj3120637

WIN 55,212-2 mesylate Preparation Products And Raw materials

Raw materials

Preparation Products

WIN 55,212-2 mesylate Suppliers

Global Suppliers ( 166)
Supplier Tel Email Country ProdList Advantage
Shanghai Zhiyun Biotechnology Co., Ltd 13119135307 China 2766 58
Shanghai Boyle Chemical Co., Ltd. sales@boylechem.com China 2915 55
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
Chembest Research Laboratories Limited 021-20908456 sales@BioChemBest.com China 5996 61
Ascent Scientific 4401179829988 customerservice@ascentscientific.co.uk United Kingdom 279 60
Shanghai Sunway Pharmaceutical Technology Co., Ltd 13761987713 hxzheng@sunwaypharm.cn China 8663 57
Hunan Hui Bai Shi Biotechnology Co., Ltd. 0731-85526065 13308475853 ivy@hnhbsj.com China 7236 62
Maya High Purity Chemicals +86 (573) 82222445 (0)18006601000 452520369 sales@maya-r.com China 11693 57
Dalian Meilun Biotech Co., Ltd. 0411-62910999 13889544652 sales@meilune.com China 4765 58
Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 7545 61
Supplier Advantage
Shanghai Zhiyun Biotechnology Co., Ltd 58
Shanghai Boyle Chemical Co., Ltd. 55
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Chembest Research Laboratories Limited 61
Ascent Scientific 60
Shanghai Sunway Pharmaceutical Technology Co., Ltd 57
Hunan Hui Bai Shi Biotechnology Co., Ltd. 62
Maya High Purity Chemicals 57
Dalian Meilun Biotech Co., Ltd. 58
Haoyuan Chemexpress Co., Ltd. 61

View Latest Price from WIN 55,212-2 mesylate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
WIN 55,212-2 MESYLATE pictures 2026-09-14 WIN 55,212-2 MESYLATE
131543-23-2
 0.99 RongNa Biotechnology Co.,Ltd
(+)-Win 55212-2 mesylate pictures 2025-06-20 (+)-Win 55212-2 mesylate
131543-23-2
 10G 0.99 1000g Hebei Yanxi Chemical Co., Ltd.
WIN 55212-2 mesylate pictures 2025-04-04 WIN 55212-2 mesylate
131543-23-2
 1kg 98% 1Ton Henan Aochuang Chemical Co.,Ltd.

131543-23-2 (WIN 55,212-2 mesylate) Related Search:

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3-Acetylindole 2-Methylindole-3-carboxaldehyde 1-Ethyl-2-methylindole 7-Hydroxyindole 7-Methoxy-1H-indole
7-Methoxy-3-indolecarboxaldehyde 3-Morpholinopropanol 1,2-Dimethylindole ASISCHEM W99822 4-(2-aminopropyl)morpholine
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(+)-WIN 55,212-2 mesylate - CAS 131543-23-2 - Calbiochem CS-754 WIN552122;WIN-552122 R(+)-WIN 55,212-2 ,MESYLATE HIGH AFFINIT Y CANNABI (R)-(+)-(2,3-Dihydro-5-methyl-3-(4-morpholinylmethyl)pyrrolo[1.2.3-de]-1,4-benzoxazin-6-yl)-1-naphthalenylmethanonemesy 212-2Mesylate (R)-(+)-[2,3-Dihydro-5-methyl-3[(4-morpholinyl)methyl]pyrrolo[1,2,3-de]-1,4-benzoxazinyl]-(1-naphthalenyl)methanone mesylate salt (R)-(+)-WIN 55,212-2 mesylate salt WIN 552122 mesylate, (R)-(+)-[2,3-Dihydro-5-methyl-3[(4-morpholinyl)methyl]pyrrolo[1,2,3-de]-1,4-benzoxazinyl]-(1-naphthalenyl)methanone mesylate salt (R)-(5-Methyl-3-(MorpholinoMethyl)-2,3-dihydro-[1,4]oxazino[2,3,4-hi]indol-6-yl)(naphthalen-1-yl)Methanone (R)-(5-Methyl-3-(MorpholinoMethyl)-2,3-dihydro-[1,4]oxazino[2,3,4-hi]indol-6-yl)(naphthalen-1-yl)Methanone Methanesulfonate (R)-(5-Methyl-3-(morpholinomethyl)-2,3-dihydro-[1,4]oxazino-[2,3,4-hi]indol-6-yl)(naphthalen-1-yl WIN 55212-2 methanesulfonate WIN552122;WIN-552122;(R)-(+)-WIN 55212 (R)-(5-Methyl-3-(morpholinomethyl)-2,3-dihydro-[1,4]oxazino-[2,3,4-hi]indol-6-yl)(naphthalen-1 (R)-(+)-[2,3-DIHYDRO-5-METHYL-3-(4-MORPHOLINYLMETHYL)PYRROLO[1,2,3-DE]-1,4-BENZOXAZIN-6-YL]-1-NAPHTHALENYLMETHANONE MESYLATE R(+)-[2,3-DIHYDRO-5-METHYL-3-[(MORPHOLINYL)METHYL]PYRROLO[1,2,3-DE]-1,4-BENZOXAZINYL]-(1-NAPHTHALENYL)METHANONE MESYLATE R(+)-WIN 55,212-2 MESYLATE [(3R)-2,3-Dihydro-5-methyl-3-(4-morpholinylmethyl)pyrrolo[1,2,3-de]-1,4-benzoxazin-6-yl]-1-naphthalenyl-methanone Monomethanesulfonate (R)-(+)-WIN 55,212-2 mesylate salt >=98% (HPLC) (R)-(+)-2,3-Dihydro-5-methyl-3-(4-morpholinylmethyl)pyrrolo1,2,3-de-1,4-benzoxazin-6-yl-1-naphthalenylmethan one mesylate (R)-(+)-WIN 55,212-2 mesylate salt QLv2 WIN 55,212-2 WIN55 WIN 55,212-2 mesylate 131543-23-2 C28H30N2O6S Cannabinoid receptor Cannabinoid