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JNJ-54166060

JNJ-54166060 structure

CAS No.: 1627900-42-8

Chemical Name:: JNJ-54166060

Synonyms: JNJ-54166060;(S)-JNJ-54166060;(R)-(2-CHLORO-3-(TRIFLUOROMETHYL)PHENYL)(1-(5-FLUOROPYRIDIN-2-YL)-4-METHYL-6,7-DIHYDRO-1H-IMIDAZO[4,5-C]PYRIDIN-5(4H)-YL)METHANONE;Methanone, [2-chloro-3-(trifluoromethyl)phenyl][(4S)-1-(5-fluoro-2-pyridinyl)-1,4,6,7-tetrahydro-4-methyl-5H-imidazo[4,5-c]pyridin-5-yl]-

CBNumber:: CB83369746

Molecular Formula:: C20H15ClF4N4O

Molecular Weight:: 438.81

MDL Number:

MOL File:: 1627900-42-8.mol

TDS File:: TDS

Last updated:2026-04-24 14:59:07

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JNJ-54166060 Properties

Boiling point	586.7±50.0 °C(Predicted)
Density	1.49±0.1 g/cm3(Predicted)
pka	3.72±0.40(Predicted)

JNJ-54166060 Chemical Properties, Uses, Production

Uses

(S)-JNJ-54166060 is an enantiomer of JNJ 54166060. JNJ 54166060 is a potent P2X7 antagonist[1].

IC 50

P2X7 Receptor

References

[1] Swanson DM, et al. Identification of (R)-(2-Chloro-3-(trifluoromethyl)phenyl)(1-(5-fluoropyridin-2-yl)-4-methyl-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)methanone (JNJ 54166060), a Small Molecule Antagonist of the P2X7 receptor. J Med Chem. 2016;59(18):8535-8548. DOI:10.1021/acs.jmedchem.6b00989

JNJ-54166060 Preparation Products And Raw materials

Raw materials

Preparation Products

JNJ-54166060 Suppliers

Global Suppliers ( 5)

Supplier	Tel	Email	Country	ProdList	Advantage
Jinan Yaoyan Pharmaceutical Co., Ltd.		jnyaoyan@163.com	China	3057	58
Nanjing Meihao Pharmaceutical Technology Co., Ltd.	meitaochem@126.com	meitaochem@126.com	China	19087	58
TargetMol Chemicals Inc.	+1-781-999-5354; +1-00000000000	marketing@targetmol.com	United States	32431	58
https://hanhongsci.com/	021-54306202 18917919676	info@hanhongsci.com	China	29982	58

Supplier	Advantage
Jinan Yaoyan Pharmaceutical Co., Ltd.	58
Nanjing Meihao Pharmaceutical Technology Co., Ltd.	58
TargetMol Chemicals Inc.	58
https://hanhongsci.com/	58

1627900-42-8 (JNJ-54166060) Related Search:

(R)-(2-Chloro-3-(trifluoromethyl)phenyl)(1-(5-fluoropyridin-2-yl)-4-methyl-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl)methanone (2-Chloro-3-(trifluoromethyl)phenyl)(1-(5-fluoropyridin-2-yl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl)methanone JNJ-54166060 Ppads tetrasodium salt SODIUM METATUNGSTATE

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(R)-(2-CHLORO-3-(TRIFLUOROMETHYL)PHENYL)(1-(5-FLUOROPYRIDIN-2-YL)-4-METHYL-6,7-DIHYDRO-1H-IMIDAZO[4,5-C]PYRIDIN-5(4H)-YL)METHANONE JNJ-54166060 Methanone, [2-chloro-3-(trifluoromethyl)phenyl][(4S)-1-(5-fluoro-2-pyridinyl)-1,4,6,7-tetrahydro-4-methyl-5H-imidazo[4,5-c]pyridin-5-yl]- (S)-JNJ-54166060 1627900-42-8 C20H15ClF4N4O