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| | JNJ-54166060 Basic information |
| Product Name: | JNJ-54166060 | | Synonyms: | (R)-(2-CHLORO-3-(TRIFLUOROMETHYL)PHENYL)(1-(5-FLUOROPYRIDIN-2-YL)-4-METHYL-6,7-DIHYDRO-1H-IMIDAZO[4,5-C]PYRIDIN-5(4H)-YL)METHANONE;JNJ-54166060;Methanone, [2-chloro-3-(trifluoromethyl)phenyl][(4S)-1-(5-fluoro-2-pyridinyl)-1,4,6,7-tetrahydro-4-methyl-5H-imidazo[4,5-c]pyridin-5-yl]-;(S)-JNJ-54166060 | | CAS: | 1627900-42-8 | | MF: | C20H15ClF4N4O | | MW: | 438.81 | | EINECS: | | | Product Categories: | | | Mol File: | 1627900-42-8.mol |  |
| | JNJ-54166060 Chemical Properties |
| Boiling point | 586.7±50.0 °C(Predicted) | | density | 1.49±0.1 g/cm3(Predicted) | | pka | 3.72±0.40(Predicted) |
| | JNJ-54166060 Usage And Synthesis |
| Uses | (S)-JNJ-54166060 is an enantiomer of JNJ 54166060. JNJ 54166060 is a potent P2X7 antagonist[1]. | | IC 50 | P2X7 Receptor | | References | [1] Swanson DM, et al. Identification of (R)-(2-Chloro-3-(trifluoromethyl)phenyl)(1-(5-fluoropyridin-2-yl)-4-methyl-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)methanone (JNJ 54166060), a Small Molecule Antagonist of the P2X7 receptor. J Med Chem. 2016;59(18):8535-8548. DOI:10.1021/acs.jmedchem.6b00989 |
| | JNJ-54166060 Preparation Products And Raw materials |
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