5-Norbornene-2,3-dicarboxylic acid
- CAS No.
- 3813-52-3
- Chemical Name:
- 5-Norbornene-2,3-dicarboxylic acid
- Synonyms
- BICYCLO[2.2.1]HEPT-5-ENE-2,3-DICARBOXYLIC ACID;cis-5-Norbornene-endo-2,3-dicarboxylic acid 98%;(2R,3S)-Bicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic acid;Nadic acid;5-Norbornene-2;Einecs 223-301-0;3-dicarboxylic acid;CIS,ENDO-BICYCLO[2.2.1]-5-;5-NORBORENE-2,3-DICARBOXYLICACID;5-Norbornene-2,3-dicarboxylicaci
- CBNumber:
- CB8350255
- Molecular Formula:
- C9H10O4
- Molecular Weight:
- 182.17
- MDL Number:
- MFCD00003735
- MOL File:
- 3813-52-3.mol
- MSDS File:
- SDS
| Melting point | 175 °C (dec.)(lit.) |
|---|---|
| Boiling point | 275.56°C (rough estimate) |
| Density | 1.2481 (rough estimate) |
| refractive index | 1.4345 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| pka | 3.91±0.40(Predicted) |
| form | solid |
| color | White |
| InChI | 1S/C9H10O4/c10-8(11)6-4-1-2-5(3-4)7(6)9(12)13/h1-2,4-7H,3H2,(H,10,11)(H,12,13)/t4-,5+,6-,7+ |
| InChIKey | NIDNOXCRFUCAKQ-UMRXKNAASA-N |
| SMILES | OC(=O)[C@@H]1[C@H]2C[C@H](C=C2)[C@@H]1C(O)=O |
| FDA UNII | 51MWF38CQG |
| UNSPSC Code | 12161600 |
| NACRES | NA.23 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312+H332-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280-P301+P312-P302+P352+P312-P304+P340+P312-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 20/21/22-36/37/38 | |||||||||
| Safety Statements | 26-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 2917399590 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Dermal Acute Tox. 4 Inhalation Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
5-Norbornene-2,3-dicarboxylic acid price More Price(42)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 216704 | cis-5-Norbornene-endo-2,3-dicarboxylic acid 98% | 3813-52-3 | 5g | $192 | 2026-04-30 | Buy |
| Sigma-Aldrich | 216704 | cis-5-Norbornene-endo-2,3-dicarboxylic acid 98% | 3813-52-3 | 25g | $620 | 2026-04-30 | Buy |
| TCI Chemical | N1029 | 5-Norbornene-2,3-dicarboxylic Acid >98.0%(GC)(T) | 3813-52-3 | 5g | $64 | 2026-04-30 | Buy |
| TCI Chemical | N1029 | 5-Norbornene-2,3-dicarboxylic Acid >98.0%(GC)(T) | 3813-52-3 | 25g | $317 | 2026-04-30 | Buy |
| Apolloscientific | OR350049 | Bicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic acid 98% | 3813-52-3 | 1g | $21 | 2026-06-04 | Buy |
5-Norbornene-2,3-dicarboxylic acid Chemical Properties, Uses, Production
Chemical Properties
white powder
Uses
5-Norbornene-2,3-dicarboxylic acid is used to prepare cyclic olefin copolymers and is also an important raw material for the synthesis of the antidepressant drug lurasidone.
Health Hazard
5-Norbornene-2,3-dicarboxylic acid Causes skin irritation and serious eye irritation, it may cause respiratory irritation, it is harmful if swallowed, in contact with skin or if inhaled.
Synthesis
826-62-0
3813-52-3
The general procedure for the synthesis of 5-norbornene-2,3-dicarboxylic acid from nadic anhydride was as follows: in a 125 mL three-necked flask, 8 g of maleic anhydride and 26 mL of ethyl acetate were added, and the mixture was heated through a hot water bath until all solids were completely dissolved. Subsequently, 26 mL of petroleum ether (boiling range 60-90 °C) was added and the mixture was cooled to room temperature. Next, the mixture was further cooled using an ice water bath and 6 mL of freshly distilled cyclopentadiene was slowly added. The reaction mixture was placed in an ice-water bath with continuous stirring until a white solid precipitate precipitated, forming white needle-like crystals. The product was collected by diafiltration and washed with 15 mL of a mixture of ethyl acetate and petroleum ether. 12 g of Bicyclo[2.2.1]-2-heptene-5,6-dicarboxylic anhydride was finally obtained in about 84% yield with a melting point of 163.5-165.5 °C. 12 g of the above product was dissolved in 35 mL of 20% sodium hydroxide solution and heated to reflux for 1.5 h. The color of the solution changed from colorless to yellow. After continuing to reflux for 2 hours, the heating was stopped and cooled to room temperature. The reaction solution was transferred to a 100 mL beaker and filtered while hot. After the filtrate was cooled, it was acidified with concentrated hydrochloric acid to pH 2-3, and white needle-like crystals were precipitated. The crystals were collected by filtration and dried to give 10 g of 5-norbornene-2,3-dicarboxylic acid in 84% yield with a melting point of 167-168 °C.
References
[1] Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1989, vol. 38, # 4.2, p. 789 - 792
[2] Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1989, # 4, p. 878 - 882
[3] Patent: CN106905377, 2017, A. Location in patent: Paragraph 0038; 0039; 0040
5-Norbornene-2,3-dicarboxylic acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| TAIYUAN RHF CO.,LTD. | +86 351 7031519 | sales@RHFChem.com | China | 2334 | 56 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Puyang Huicheng Electronic Material Co. Ltd. | 0393-0393-8910800 15039333257 | info@huichengchem.com | China | 588 | 64 |
| Aemon Chemical | 0086-755-86198205 | acinfo@aemonchem.com | China | 1928 | 57 |
| ZhengZhou HuaWen Chemical Co.Ltd | 0370-2785118 17550508557 | 675141927@qq.com | China | 3201 | 55 |
| T&W GROUP | 021-61551611 13296011611 | contact@trustwe.com | China | 9884 | 58 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 13913916777 | cfzhang@aikonchem.com | China | 19902 | 55 |
View Latest Price from 5-Norbornene-2,3-dicarboxylic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | Nadic acid
3813-52-3
|
$1.00-200.00 | 1KG | 99%, 99.5% Sublimated | Henan Fengda Chemical Co., Ltd | ||
 |
2026-06-04 | 5-Norbornene-2,3-dicarboxylic acid
3813-52-3
|
$985.00 | 1KG | 99% | 1000000KG | Henan Research New Materials Co., Ltd. | |
 |
2024-07-16 | 5-Norbornene-2,3-dicarboxylic acid
3813-52-3
|
$1.00 | 1KG | 99% | 20t | Shaanxi Dideu Medichem Co. Ltd |
-
- Nadic acid
3813-52-3
- $1.00-200.00
- 99%, 99.5% Sublimated
- Henan Fengda Chemical Co., Ltd
-
- 5-Norbornene-2,3-dicarboxylic acid
3813-52-3
- $985.00
- 99%
- Henan Research New Materials Co., Ltd.
-
- 5-Norbornene-2,3-dicarboxylic acid
3813-52-3
- $1.00
- 99%
- Shaanxi Dideu Medichem Co. Ltd
