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Bis(2,2,2-trifluoroethyl) phosphite

Bis(2,2,2-trifluoroethyl) phosphite Structure
Bis(2,2,2-trifluoroethyl) phosphite structure
CAS No.
92466-70-1
Chemical Name:
Bis(2,2,2-trifluoroethyl) phosphite
Synonyms
BIS(2,2,2-TRIFLUOROETHYL) PHOSPHONATE;Bis(2,2,2-trifluoroethyl) phosphite;Bis(2,2,2-trifluoroethyl) Phosphite >PHOSPHONIC ACID BIS(2,2,2-TRIFLUOROETHYL) ESTER;BIS(2,2,2-TRIFLUOROETHYL) PHOSPHITE, TEC H., 90%;PHOSPHOROUS ACID BIS(2,2,2-TRIFLUOROETHYL) ESTER;Bis(2,2,2-trifluoroethyl) phosphite technical grade, 90%;Bis(2,2,2-trifluoroethyl) phosphite,Phosphonic acid bis(2,2,2-trifluoroethyl) ester;Bis(2,2,2-trifluoroethyl) Phosphonate Phosphonic Acid Bis(2,2,2-trifluoroethyl) Ester Phosphorous Acid Bis(2,2,2-trifluoroethyl) Ester
CBNumber:
CB8384111
Molecular Formula:
C4H5F6O3P
Molecular Weight:
246.05
MDL Number:
MFCD00063314
MOL File:
92466-70-1.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:55:42
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Bis(2,2,2-trifluoroethyl) phosphite Properties

Boiling point 43-44 °C/2 mmHg (lit.)
Density 1.545 g/mL at 25 °C (lit.)
refractive index n20/D 1.332(lit.)
Flash point 169 °F
form Liquid
color Colorless to Almost colorless
InChI 1S/C4H5F6O3P/c5-3(6,7)1-12-14(11)13-2-4(8,9)10/h14H,1-2H2
InChIKey NYQKUVUXMIHXEA-UHFFFAOYSA-N
SMILES FC(F)(F)CO[PH](=O)OCC(F)(F)F
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P302+P352-P305+P351+P338
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  23-26-28-36
WGK Germany  3
HS Code  2920.90.5100
Storage Class 11 - Combustible Solids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
2
2 0

Bis(2,2,2-trifluoroethyl) phosphite price More Price(16)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 340995 Bis(2,2,2-trifluoroethyl) phosphite technical grade, 90% 92466-70-1 5g $84.7 2023-01-07 Buy
Sigma-Aldrich 340995 Bis(2,2,2-trifluoroethyl) phosphite technical grade, 90% 92466-70-1 25g $190 2023-01-07 Buy
TCI Chemical B2627 Bis(2,2,2-trifluoroethyl) Phosphite >94.0%(GC) 92466-70-1 5g $50 2026-04-30 Buy
TCI Chemical B2627 Bis(2,2,2-trifluoroethyl) Phosphite >94.0%(GC) 92466-70-1 25g $146 2026-04-30 Buy
Chem-Impex 46430 Bis(2,2,2-trifluoroethyl) phosphite ≥94%(GC) 92466-70-1 5G $73.9 2026-05-19 Buy
Product number Packaging Price Buy
340995 5g $84.7 Buy
340995 25g $190 Buy
B2627 5g $50 Buy
B2627 25g $146 Buy
46430 5G $73.9 Buy

Bis(2,2,2-trifluoroethyl) phosphite Chemical Properties, Uses, Production

Uses

Bis(2,2,2-trifluoroethyl) phosphite was used in the synthesis of bis(2,2,2-trifluoroethyl phosphorochloridate. It was also employed as reagent for the synthesis of mono- and diesters of phosphorous acid.

Synthesis Reference(s)

Synthesis, p. 410, 1984 DOI: 10.1055/s-1984-30856

Synthesis

The synthesis method of Bis(2,2,2-trifluoroethyl) Phosphite is as follows: A solution of phosphorus trichloride (43.5 mL, 0.50 mol) in dichloromethane (100 mL) was placed in an oven dried 1L round bottom flask. A reflux condenser and pressure equalizing addition funnel were attached to the round bottom flask. The addition funnel was charged with a solution of 2-methyl-2-propanol (48.0 mL, 0.50 mol) in dichloromethane (100 mL), and then the contents of the addition funnel were added in a dropwise manner to the round bottom flask under argon gas at 0 ℃over the course of 30 min. The reaction mixture was allowed to stir for an additional 30 min, then the addition funnel is recharged with a solution of 2,2,2-trifluoroethanol (70.0 mL, 0.96 mol) and dichloromethane (100 mL) and then the contents of the addition funnel were added in a dropwise manner to the round bottom flask under argon gas at 0 ℃ over the course of 30 min. The reaction mixture was then allowed to stir at RT overnight. The gaseous vapors were then degassed into NaOH (30.2 g, 0.98 mol) in 200 mL of water over the course of 8 hrs. The solvents were removed by rotary evaporation and the crude material was fractionally distilled under reduced pressure yielding Bis(2,2,2-trifluoroethyl) Phosphite (100.89 g, 0.41 mol, 82.2%) as colorless liquid.

Bis(2,2,2-trifluoroethyl) phosphite Preparation Products And Raw materials

Raw materials

Preparation Products

Ethyl [bis(2,2,2-trifluoroethoxy)phosphinyl]acetate

Bis(2,2,2-trifluoroethyl) phosphite Suppliers

Global Suppliers ( 61)
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
TOKYO CHEMICAL INDUSTRY CO., LTD. 03-36680489 Sales-JP@TCIchemicals.com Japan 28364 80
TCI Europe 320-37350700 sales@tcieurope.eu Europe 23654 75
TCI AMERICA 800-4238616 sales@tciamerica.com Americas 23636 75
9ding chemical ( Shanghai) Limited 4009209199 sales@9dingchem.com China 22497 55
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
Shanghai Hanhong Scientific Co.,Ltd. 64
TOKYO CHEMICAL INDUSTRY CO., LTD. 80
TCI Europe 75
TCI AMERICA 75
9ding chemical ( Shanghai) Limited 55
Bide Pharmatech Ltd. 60

View Latest Price from Bis(2,2,2-trifluoroethyl) phosphite manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Bis(2,2,2-trifluoroethyl) Phosphite pictures 2026-08-07 Bis(2,2,2-trifluoroethyl) Phosphite
92466-70-1
 $1.00 1KG 99% 20 tons Shaanxi Dideu Medichem Co. Ltd
BIS(2,2,2-TRIFLUOROETHYL) PHOSPHITE pictures 2020-01-15 BIS(2,2,2-TRIFLUOROETHYL) PHOSPHITE
92466-70-1
 $1.00 1KG 99% 100KG Career Henan Chemical Co

Bis(2,2,2-trifluoroethyl) phosphite Spectrum

BIS(2,2,2-TRIFLUOROETHYL) PHOSPHITE(92466-70-1)1HNMRBIS(2,2,2-TRIFLUOROETHYL) PHOSPHITE(92466-70-1)RamanBIS(2,2,2-TRIFLUOROETHYL) PHOSPHITE(92466-70-1)FT-IRBIS(2,2,2-TRIFLUOROETHYL) PHOSPHITE(92466-70-1)IR

92466-70-1 (Bis(2,2,2-trifluoroethyl) phosphite) Related Search:

Bis(2,2,2-trifluoroethyl) (methoxycarbonylmethyl)phosphonate Phosphite [2-(2-Amino-6-chloro-purin-9-yl)-ethoxymethyl]-phosphonic acid bis-(2,2,2-trifluoro-ethyl) ester Ethyl 2-[bis(2,2,2-trifluoroethyl)phosphono] propionate Bis(2,2,2-trifluoroethyl) phosphite
alamifovir Bis(trifluoroethyl) methylphosphonate Bis-(2,2,2-trifluoroethyl) methoxycarbonylmethyl phosphonate, [1,2-14C] [Bis-(2,2,2-trifluoro-ethoxy)-phosphoryl]-bromo-acetic acid methyl ester Ethyl [bis(2,2,2-trifluoroethoxy)phosphinyl]acetate
Tris(2,2,2-trifluoroethyl)phosphate

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PHOSPHONIC ACID BIS(2,2,2-TRIFLUOROETHYL) ESTER PHOSPHOROUS ACID BIS(2,2,2-TRIFLUOROETHYL) ESTER BIS(2,2,2-TRIFLUOROETHYL) PHOSPHITE, TEC H., 90% Bis(2,2,2-trifluoroethyl) phosphite,Phosphonic acid bis(2,2,2-trifluoroethyl) ester Bis(2,2,2-trifluoroethyl) Phosphonate Phosphonic Acid Bis(2,2,2-trifluoroethyl) Ester Phosphorous Acid Bis(2,2,2-trifluoroethyl) Ester Bis(2,2,2-trifluoroethyl) phosphite technical grade, 90% Bis(2,2,2-trifluoroethyl) Phosphite > BIS(2,2,2-TRIFLUOROETHYL) PHOSPHONATE Bis(2,2,2-trifluoroethyl) phosphite 92466-70-1 C4H5F6O3P CF3CH2O2POH Organic Phosphates/Phosphites Phosphorus Compounds Organic Building Blocks Building Blocks