Bleomycin sulfate
- CAS No.
- 9041-93-4
- Chemical Name:
- Bleomycin sulfate
- Synonyms
- BLEOMYCIN SULPHATE;BLENOXANE;Bleomycin Sulfate (mixture);BLEOMYCIN SULFATE CELL CULTURE TESTED;BLEO;BLEXANE;Bleolem;BLEOcell;BLEO cell;BLEO-cell
- CBNumber:
- CB8412175
- Molecular Formula:
- C110H168N34O46S7
- Molecular Weight:
- 2927.17
- MDL Number:
- MFCD00070310
- MOL File:
- 9041-93-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 200-204°C (dec.) |
|---|---|
| storage temp. | 2-8°C |
| solubility | H2O: 20 mg/mL |
| form | powder |
| color | white |
| Water Solubility | Soluble in water or DMSO |
| Merck | 14,1318 |
| Stability | Stable for 1 year from the date of purchase. Solutions in distilled water may be stored at -20°C for up to 3 months. |
| InChIKey | OOXTWFJZZAJGKA-YWZNXBAZNA-N |
| CAS DataBase Reference | 9041-93-4(CAS DataBase Reference) |
| NCI Dictionary of Cancer Terms | bleomycin sulfate |
| FDA UNII | 7DP3NTV15T |
| NCI Drug Dictionary | bleomycin sulfate |
| UNSPSC Code | 12352200 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H340-H351-H361fd | |||||||||
| Precautionary statements | P201-P202-P280-P308+P313-P405-P501 | |||||||||
| Hazard Codes | T,Xi | |||||||||
| Risk Statements | 46-40-36/37/38-63 | |||||||||
| Safety Statements | 53-36/37-45-36-26 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | EC5991990 | |||||||||
| F | 10 | |||||||||
| HS Code | 2941906000 | |||||||||
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
|||||||||
| Hazard Classifications | Carc. 2 Muta. 1B Repr. 2 |
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| NFPA 704 |
|
Bleomycin sulfate price More Price(98)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | B8416 | Bleomycin sulfate from Streptomyces verticillus 1.5-2.0?units/mg solid, BioReagent, suitable for cell culture | 9041-93-4 | 15units | $1410 | 2026-04-30 | Buy |
| Sigma-Aldrich | B5507 | Bleomycin sulfate from Streptomyces verticillus crystalline, 1.5-2.0?U/mg | 9041-93-4 | 15units | $979 | 2026-04-30 | Buy |
| Sigma-Aldrich | B2434 | Bleomycin sulfate from Streptomyces verticillus BioXtra, crystalline | 9041-93-4 | 20mg | $1600 | 2026-04-30 | Buy |
| Sigma-Aldrich | B1141000 | Bleomycin sulfate European Pharmacopoeia (EP) Reference Standard | 9041-93-4 | 7 mg | $254 | 2026-04-30 | Buy |
| Sigma-Aldrich | 1076308 | Bleomycin sulfate | 9041-93-4 | 15mg | $1010 | 2026-04-30 | Buy |
Bleomycin sulfate Chemical Properties,Uses,Production
Description
Bleomycin sulfate (9041-93-4) coordinates with metals producing reactive oxygen species which causes oxidative damage to DNA1and RNA2. Induces double-strand DNA damage.3Commonly used to induce lung fibrosis in animal disease models.4,5Anticancer agent in clinical use.6
Chemical Properties
White Powder
Uses
Bleomycin sulfate binds to DNA, and can inhibit DNA synthesis and causes scission of DNA. Cleaves DNA, requires binding to oxygen and a metal ion, such as copper or iron. Able to cleave RNA, but at less and more selective degree. Also reported to induce and regulate apoptosis in a variety of cells, and inhibit tumor angiogenesis.
Mechanism of action
Bleomycin is a complex of 11 glycopeptide antitumor antibiotics originally isolated from Streptomyces verticillus in 1972. The dominant components of the complex are bleomycin A2 and B2, which typically represent >90% of the total weight. Bleomycins have found clinical application in the treatment of a range of tumors. Bleomycins act by intercalation of DNA and RNA. In the presence of oxygen and metal ions, notably copper and iron, bleomycins form a pseudo-enzyme that induces DNA cleavage.
brand name
Blenoxane (Bristol-Myers Squibb).
General Description
Bleomycin occurs as a white powder and is available in 15-and 30-U vials for reconstitution in water. It may be givenintravenously, intramuscularly, or subcutaneously. It is used in the treatment of squamous cell carcinoma of the headneck, cervix, penis, and vulva. It is also used in Hodgkin’sand non-Hodgkin’s lymphoma as well as testicular carcinoma.Unlabeled uses include the treatment of mycosis fungoides,osteosarcoma, and AIDS-related Kaposi sarcoma.
Biochem/physiol Actions
Bleomycin sulfate binds to DNA, causes ssDNA scission at specific base sequences and inhibits DNA synthesis. This inhibitory action requires bleomycin to bind oxygen and a metal ion. It can also cleave RNA, to a lesser degree but more selectively. It acts as an inducer and regulator of apoptosis and inhibits tumor angiogenesis.
Clinical Use
Bleomycin is used IV in the palliative treatment of squamous cell head and neck cancers, testicular and other genital carcinomas, and Hodgkin's and non-Hodgkin's lymphoma.
Side effects
It is excreted via the kidneys, and serum concentrations of active drug are increased in patients with renal disease. The elimination half-life can rise from 2 to 4 hours to more than 20 hours in renal failure, resulting in significant toxicity, especially pulmonary toxicity.
Veterinary Drugs and Treatments
Bleomycin has occasionally been used as adjunctive treatment of lymphomas, squamous cell carcinomas, teratomas, and nonfunctional thyroid tumors in both dogs and cats. Recent work has demonstrated that bleomycin may be promising for intralesional treatment for a variety of localized tumors with or without concomitant electropermeabilization.
target
UT-SCC-129 cells
References
[1] DAVID H. PETERING William E A Robert W Byrnes. The role of redox-active metals in the mechanism of action of bleomycin[J]. Chemico-Biological Interactions, 1990, 73 2: Pages 133-182. DOI:10.1016/0009-2797(90)90001-4
[2] A. HÜTTENHOFER. Cleavage of tRNA by Fe(II)-bleomycin.[J]. The Journal of Biological Chemistry, 1992, 81 1: 24471-24475. DOI:10.1016/s0021-9258(18)35790-9
[3] KYUNG YONG LEE. ASF1a Promotes Non-homologous End Joining Repair by Facilitating Phosphorylation of MDC1 by ATM at Double-Strand Breaks.[J]. Molecular Cell, 2017, 68 1: 61-75.e5. DOI:10.1016/j.molcel.2017.08.021
[4] YAN XIE. Upregulation of RGS2: a new mechanism for pirfenidone amelioration of pulmonary fibrosis.[J]. Respiratory Research, 2016: 103. DOI:10.1186/s12931-016-0418-4
[5] MINORU INOMATA. Pirfenidone inhibits fibrocyte accumulation in the lungs in bleomycin-induced murine pulmonary fibrosis.[J]. Respiratory Research, 2014: 16. DOI:10.1186/1465-9921-15-16
[6] TOSHIKO TANAKA. Increased glutathione level is not involved in enhanced bleomycin sensitivity in cisplatin-resistant 2780CP cells.[J]. Anticancer research, 2008, 28 5A: 2663-2668.
Bleomycin sulfate Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei wei shi reagent group ltd., company | 027-59102966 18717199209 | 2853877583@QQ.com | China | 7306 | 58 |
| ShangHai ChuanQian Chemcial Technique Centre | 15869524721 | 3525679403@qq.com | China | 4565 | 58 |
| Hunan ravel Biotechnology Co.,Ltd | 18627957289 18173226957 | 3628571360@qq.com | China | 2287 | 58 |
| Taizhou Creating Bio-pharm Co.,Ltd. | +86-0576-88827176 +86-18906581668 | post@creatingchemical.com | China | 220 | 58 |
| Hubei widely chemical technology Co., Ltd. | 17771478861 13419635609 | 3525818213@qq.com | China | 1887 | 55 |
| Shanghai Amole Biotechnology Co., Ltd. | 13370042665 18916960931 | 2596183085@qq.com | China | 17234 | 58 |
| Hubei Xingcheng Biotechnology Co., Ltd | 19171210221 | 3371991952@qq.com | China | 954 | 58 |
| Shanghai jerryxing Biomedical Technology Co., Ltd | 17521512546 17721492509 | 460170712@qq.com | China | 4965 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
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View Lastest Price from Bleomycin sulfate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-13 | Bleomycin sulfate
9041-93-4
|
0.99 | RongNa Biotechnology Co.,Ltd | ||||
 |
2026-09-11 | Bleomycin Sulfate
9041-93-4
|
1g | More Than 99% | 100kg/Month | BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. | ||
 |
2026-09-11 | Bleomycin sulfate
9041-93-4
|
10g | 90% | 1000 | Jinan Hong Kongda Chemical Co.,LTD |
-
- Bleomycin sulfate
9041-93-4
- 0.99
- RongNa Biotechnology Co.,Ltd
-
- Bleomycin Sulfate
9041-93-4
- $0.00
- More Than 99%
- BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
-
- Bleomycin sulfate
9041-93-4
- $0.00
- 90%
- Jinan Hong Kongda Chemical Co.,LTD
