Dithizone
- CAS No.
- 60-10-6
- Chemical Name:
- Dithizone
- Synonyms
- DIPHENYLTHIOCARBAZONE;dithizon;Dithizone (min. 98%);1,5-diphenyl-3-thiocarbazone;(E)-1,5-diphenylthiocarbazone;Diazenecarbothioic acid, 2-phenyl-, 2-phenylhydrazide;Ditizon;DITHIZONE;C13H12N4S;usafek-3092
- CBNumber:
- CB5753569
- Molecular Formula:
- C13H12N4S
- Molecular Weight:
- 256.33
- MDL Number:
- MFCD00003025
- MOL File:
- 60-10-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 168 °C (dec.) (lit.) |
|---|---|
| Boiling point | 376.1±25.0 °C(Predicted) |
| bulk density | 250kg/m3 |
| Density | 1.2578 (rough estimate) |
| refractive index | 1.5700 (estimate) |
| storage temp. | no restrictions. |
| solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
| form | Crystalline |
| pka | pK1:4.50;pK2:15 (25°C) |
| color | Black powder |
| Water Solubility | Soluble in ethanol, chloroform, dimethylsulfoxide, and pyridine. Insoluble in water. |
| λmax | 604-607 nm in chloroform |
| Merck | 14,3377 |
| BRN | 748838 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| InChI | 1S/C13H12N4S/c18-13(16-14-11-7-3-1-4-8-11)17-15-12-9-5-2-6-10-12/h1-10,14H,(H,16,18) |
| InChIKey | UOFGSWVZMUXXIY-UHFFFAOYSA-N |
| SMILES | S=C(NNc2ccccc2)N=Nc1ccccc1 |
| CAS DataBase Reference | 60-10-6(CAS DataBase Reference) |
| FDA UNII | NJZ2CJ4D6P |
| EPA Substance Registry System | Diazenecarbothioic acid, phenyl-, 2-phenylhydrazide (60-10-6) |
| UNSPSC Code | 12352127 |
| NACRES | NB.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 36-26 | |||||||||
| RIDADR | 2811 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | LQ9450000 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29309090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 |
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| NFPA 704 |
|
Dithizone price More Price(63)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | DX2370 | Dithizone Meets ACS Specifications, Meets Reagent Specifications for testing USP/NF monographs GR ACS | 60-10-6 | 25g | $1090 | 2026-04-30 | Buy |
| Sigma-Aldrich | 1.03092 | Dithizone for analysis (1,5-diphenylthiocarbazone) Reag. Ph Eur | 60-10-6 | 25g | $437 | 2026-04-30 | Buy |
| Sigma-Aldrich | 1.03092 | Dithizone for analysis (1,5-diphenylthiocarbazone) Reag. Ph Eur | 60-10-6 | 5G | $158 | 2024-03-01 | Buy |
| TCI Chemical | D0949 | Dithizone | 60-10-6 | 5G | $40 | 2026-04-30 | Buy |
| TCI Chemical | D0949 | Dithizone >85.0%(E) | 60-10-6 | 25g | $97 | 2026-04-30 | Buy |
Dithizone Chemical Properties, Uses, Production
Chemical Properties
dark brown or black crystals
Uses
Dithizone is an organosulfur compound that acts as a chelating agent and forms complexes with metals such as lead and mercury. Dithizone is used to assess the purity of human pancreatic islet preparations used for transplantation into patients with type 1 diabetes.
Uses
Sensitive reagent for several heavy metals, Co, Cu, Pb, and Hg; especially for the estimation of minute amounts of Pb.
Uses
Dithizone is used as an indicator for minute amounts of lead. It acts as a chelating agent for heavy metal poisoning. As a ligand, it forms complexes with metals like zinc, lead and mercury. Further, it is used to assess the purity of human pancreatic islet preparations, which is used for transplantation in patients with type 1 diabetes. In addition to this, it is used as a titrant in the quantitative determination of heavy metals.
Definition
ChEBI: Dithizone is a member of phenylhydrazines.
General Description
Dithizone (Diphenylthiocarbazone) is used as chelating agent for zinc. It is widely used for the liquid-liquid and solid phase extraction of various metals since it forms stable complexes with the metals.
Purification Methods
The crude dithizone is dissolved in CCl4 to give a concentrated solution. This is filtered through a sintered glass funnel and shaken with 0.8M aqueous ammonia to extract dithizonate ion. The aqueous layer is washed with several portions of CCl4 to remove undesirable materials. The aqueous layer is acidified with dilute H2SO4 to precipitate pure dithizone. This is dried in a vacuum. When only small amounts of dithizone are required, purification by paper chromatography is convenient. [Cooper & Hibbits J Am Chem Soc 75 5084 1933.] Instead of CCl4, CHCl3 can be used, and the final extract, after washing with water, can be evaporated in air at 40-50o and dried in a desiccator. It complexes with Cd, Hg, Ni and Zn. [Beilstein 16 H 26, 16 IV 18.]
Dithizone Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shenyang Xianchuang Chemical Co., Ltd. | 024-23769576 13840269002 | 274311108@qq.com | China | 358 | 58 |
| Chengdu HuaXia Chemical Reagent Co. Ltd | 400-1166-196 13458535857 | cdhxsj@163.com | China | 13323 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Beijing HwrkChemical Technology Co., Ltd | 89508211 18501085097 | sales.bj@hwrkchemical.com | China | 9407 | 55 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
View Latest Price from Dithizone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-22 | Dithizone
60-10-6
|
1kg | 80% | 20MT | Watson Biotechnology Co.,Ltd | ||
 |
2026-03-20 | Dithizone
60-10-6
|
$10.00 | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2024-04-24 | Dithizone
60-10-6
|
$5.00 | 1kg | 99.92% | 50000tons | Ouhuang Engineering Materials (Hubei) Co., Ltd |
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