p-Chlorobenzoic anhydride
- CAS No.
- 790-41-0
- Chemical Name:
- p-Chlorobenzoic anhydride
- Synonyms
- AI314648;AI3-14648;AI3 14648;Rebamipide Impurity 53;4-chlorophenyl anhydride;4-CHLOROBENZOIC ANHYDRIDE;p-Chlorobenzoic anhydride;bis(4-chlorobenzoic) anhydride;(4-chlorobenzoyl) 4-chlorobenzoate;4-chloro-Benzoic acid 1,1'-anhydride
- CBNumber:
- CB8423867
- Molecular Formula:
- C14H8Cl2O3
- Molecular Weight:
- 295.12
- MDL Number:
- MFCD00054415
- MOL File:
- 790-41-0.mol
- MSDS File:
- SDS
| Melting point | 193-194 °C(Solv: water (7732-18-5); acetone (67-64-1)) |
|---|---|
| Boiling point | 248 °C(Press: 5 Torr) |
| Density | 1.401±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | Acetone (Slightly), Chloroform (Slightly) |
| form | Solid |
| color | White to Off-White |
| Stability | Moisture Sensitive |
| FDA UNII | PV5DQN38UK |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 |
| Hazard Codes | T |
p-Chlorobenzoic anhydride price More Price(32)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | TRC-C427630-500MG | 4-Chlorobenzoic anhydride | 790-41-0 | 500mg | $103 | 2026-06-03 | Buy |
| TRC | TRC-C427630-250MG | 4-Chlorobenzoic anhydride | 790-41-0 | 250mg | $91 | 2026-06-03 | Buy |
| TRC | TRC-C427630-100MG | 4-Chlorobenzoic anhydride | 790-41-0 | 100mg | $72 | 2026-06-03 | Buy |
| Activate Scientific | AS41854 | 4-Chlorobenzoic anhydride 97% | 790-41-0 | 1g | $62 | 2026-06-04 | Buy |
| Activate Scientific | AS41854 | 4-Chlorobenzoic anhydride 97% | 790-41-0 | 5g | $123 | 2026-06-04 | Buy |
p-Chlorobenzoic anhydride Chemical Properties, Uses, Production
Preparation
To a flask containing 17.5 gm (0.1 mole) of p-chlorobenzoyl chloride is added 50 ml (0.6 mole) of pyridine and the mixture heated for 5 min on the steam bath. The mixture is poured upon 100 gm of cracked ice and 50 ml of concentrated hydrochloric acid, allowed to warm to room temperature, filtered, the solid washed successively with 15 ml of methanol and 15 ml of dry benzene, and dried to afford 14.2-14.6 gm (96-98%), m.p. 192- 193°C (recrystallized from 250 ml of dry benzene).
Synthesis
74-11-3
790-41-0
GENERAL METHOD: Iodine (0.1573 g, 0.62 mmol) was dissolved in dichloromethane (2 mL) at 0 °C, followed by a one-time addition of triphenylphosphine (0.1626 g, 0.62 mmol). Next, p-chlorobenzoic acid (0.41 mmol) was added to the mixture, and triethylamine (0.17 mL, 1.23 mmol) was added at 0 °C. The reaction mixture was gradually warmed to room temperature and stirred continuously until the reaction was complete (usually about 10 minutes). Upon completion of the reaction, the crude product was concentrated under reduced pressure and subsequently purified by column chromatography (CC) using a hexane solution of 5-10% ethyl acetate as eluent to give the final 4-chlorobenzoic anhydride.
References
[1] Tetrahedron Letters, 2016, vol. 57, # 3, p. 325 - 328
[2] Synthesis, 1981, # 8, p. 616 - 620
[3] Tetrahedron Letters, 1986, vol. 27, # 41, p. 4937 - 4940
[4] Synthesis, 1981, # 3, p. 218 - 220
[5] Synthetic Communications, 1983, vol. 13, # 6, p. 471 - 488
p-Chlorobenzoic anhydride Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
p-Chlorobenzoic anhydride Suppliers
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