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KN-62

KN-62 Structure
KN-62 structure
CAS No.
127191-97-3
Chemical Name:
KN-62
Synonyms
KN-2;N 62;KN-62;CS-756;KN-62 97%;KN-62,97%;KN 62;KN-2;KN-62, 99+%;KN 62; KN62;KN-62, >=98%
CBNumber:
CB8443368
Molecular Formula:
C38H35N5O6S2
Molecular Weight:
721.84
MDL Number:
MFCD00083180
MOL File:
127191-97-3.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-13 20:36:59
Product description Number Pack Size Price
KN-62 ≥95%, powder I2142 0.5 mg $146
KN-62 ≥95%, powder I2142 .5mg $136
KN-62 422706 1mg $181
KN-62 ≥98% 13318 1mg $54
KN-62 ≥98% 13318 5mg $120
More product size
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KN-62 Properties

Melting point 92-94°C
Boiling point 964.7±75.0 °C(Predicted)
Density 1.388
storage temp. -20°C
solubility 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.93 mg/mL
pka 4.07±0.13(Predicted)
form solid
color white
biological source synthetic (organic)
InChIKey RJVLFQBBRSMWHX-DHUJRADRSA-N
SMILES O=S(OC1=CC=C(C[C@@H](C(N2CCN(C3=CC=CC=C3)CC2)=O)N(C)S(C4=CC=CC5=C4C=CN=C5)(=O)=O)C=C1)(C6=CC=CC7=C6C=CN=C7)=O
CAS DataBase Reference 127191-97-3(CAS DataBase Reference)
FDA UNII 63HM46XPOW
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

PPE Eyeshields, Gloves, type N95 (US)
Safety Statements  24/25
WGK Germany  3
HS Code  29339980
Storage Class 11 - Combustible Solids

KN-62 price More Price(84)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich I2142 KN-62 ≥95%, powder 127191-97-3 0.5 mg $146 2026-04-30 Buy
Sigma-Aldrich I2142 KN-62 ≥95%, powder 127191-97-3 .5mg $136 2025-07-31 Buy
Sigma-Aldrich 422706 KN-62 127191-97-3 1mg $181 2023-01-07 Buy
Cayman Chemical 13318 KN-62 ≥98% 127191-97-3 1mg $54 2026-04-30 Buy
Cayman Chemical 13318 KN-62 ≥98% 127191-97-3 5mg $120 2026-04-30 Buy
Product number Packaging Price Buy
I2142 0.5 mg $146 Buy
I2142 .5mg $136 Buy
422706 1mg $181 Buy
13318 1mg $54 Buy
13318 5mg $120 Buy

KN-62 Chemical Properties,Uses,Production

Chemical Properties

Yellow Solid

Uses

A specific inhibitor of Ca2+/Calmodulin-dependent protein kinase II

Uses

selectively inhibits rat brain Ca2+/cadmodulin-dependent protein kinase II,

Uses

It is used as a potent and selective inhibitor of CaMKII. KN-62 has demonstrated potent and selective inhibition of Ca2+/calmodulin-dependent protein kinase II (CaMKII; Ki=0.9 M) which causes cells to arrest in the S phase. In HEK-293 cells expressing type III adenylyl cyclase (III-AC), 10 M of KN-62 blocked CaMKII phosphorylation of III-AC, and inhibited hormone-stimulated Ca2+ oscillations. Additionally, KN-62 is a potent non-competitive antagonist at the P2X7 receptor (IC50 = 15 nM).

Definition

ChEBI: 5-isoquinolinesulfonic acid [4-[(2S)-2-[5-isoquinolinylsulfonyl(methyl)amino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenyl] ester is a member of piperazines.

General Description

A cell-permeable, reversible, and selective inhibitor of CaM kinase II (Ki = 900 nM for rat brain CaM kinase II) that binds directly to the calmodulin binding site of the enzyme. Also inhibits the growth of K562 cells in a dose-dependent manner.

Biological Activity

Selective, cell-permeable inhibitor of CaM kinase II (IC 50 = 0.9 μ M). Binds directly to the calmodulin binding site of the enzyme. Potent non-competitive antagonist at the P2X 7 receptor (IC 50 = 15 nM). Also available as part of the Mixed Kinase Inhibitor Tocriset™ .

Biochem/physiol Actions

Selectively inhibits rat brain Ca2+/calmodulin-dependent protein kinase II.

storage

-20°C (desiccate)

KN-62 Preparation Products And Raw materials

Raw materials

Preparation Products

KN-62 Suppliers

Global( 209)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49979 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29792 58
Zhengzhou Alfa Chemical Co.,Ltd 		+8618530059196 sale04@alfachem.cn China 9553 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32466 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6312 58
Dideu Industries Group Limited 		+86-86-15536356810 +8617392712697 1022@dideu.com China 29072 58
Hefei Hirisun Pharmatech Co., Ltd 		+8615056975894 shawn@hirisunpharm.com CHINA 9911 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471; sales@sarms4muscle.com China 10472 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
CONIER CHEM AND PHARMA LIMITED 		58
career henan chemical co 		58
Zhengzhou Alfa Chemical Co.,Ltd 		58
TargetMol Chemicals Inc. 		58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
Dideu Industries Group Limited 		58
Hefei Hirisun Pharmatech Co., Ltd 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
InvivoChem 		58

View Lastest Price from KN-62 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
KN-62 pictures 2026-07-13 KN-62
127191-97-3
 $30.00-68.00 99.80% 10g TargetMol Chemicals Inc.
KN-62 pictures 2025-04-04 KN-62
127191-97-3
 1kg 98% 1Ton Henan Aochuang Chemical Co.,Ltd.
KN-62 pictures 2020-02-01 KN-62
127191-97-3
 $3.00 1KG 98% 100KG Career Henan Chemical Co
  • KN-62 pictures
  • KN-62
    127191-97-3
  • $30.00-68.00
  • 99.80%
  • TargetMol Chemicals Inc.
  • KN-62 pictures
  • KN-62
    127191-97-3
  • 98%
  • Henan Aochuang Chemical Co.,Ltd.
  • KN-62 pictures
  • KN-62
    127191-97-3
  • $3.00
  • 98%
  • Career Henan Chemical Co

KN-62 Spectrum

KN-62(127191-97-3)MSKN-62(127191-97-3)1HNMR

127191-97-3(KN-62)Related Search:

1-Acetylpiperazine N-Aminoethylpiperazine 1-ACETYL-4-METHYLPIPERAZINE HYDROCHLORIDE 1-(3-PHENYLPROPYL)PIPERAZINE 5-Isoquinolinesulfonic acid
4-Methyl-1-piperazineethanamine 1-Piperazineethanamine,N,4-dimethyl-(9CI) 1-(4-phenylpiperazin-1-yl)propan-2-amine 1-(4-PHENYLPIPERAZIN-1-YL)ETHANONE 1-ETHYL-4-PHENYLPIPERAZINE
N-[2-(4-HYDROXYPHENYL)ETHYL]-METHANESULFONAMIDE 2-(4-PHENYLPIPERAZIN-1-YL)ETHANAMINE KN-62 N-phenethylmethanesulphonamide 1-(PROPANOYL)-PIPERAZINE
KN-62 **NOT FOR SALE IN JAPAN** KN-62: HBC COMPLEX

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1-(N,O-BIS-(5-ISOQUINOLINESULFONYL)-*N-M ETHYL-L-TYR KN-62 97% KN-62, 99+% 4-((2S)-2-((5-isoquinolinylsulfonyl)methylamino)-3-oxo-3-(4-phenyl-1-piperazinyl)propyl)phenylisoquinolinesulfonicacid 1-(N,O-Bis-[5-isoquinolinesulfonyl]-N-methyl-L-tyrosyl)-4-phenylpiperazine, (S)-5-Isoquinolinesulfonic Acid 4-(2-[(5-Isoquinolinylsulfonyl)methylamino]- 3-oxo-3-[4-phenyl-1-piperazinyl]propyl)phenyl Ester, 5-Isoquinolinesulfonic acid, 4-[(2S)-2-[(5-isoquinolinylsulfonyl)methylamino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenyl ester (s)-5-isoquinolinesulfonic acid 4-[2-[(5-isoquinolinylsulfonyl)methylamino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenyl ester CS-756 KN-62 - CAS 127191-97-3 - Calbiochem KN 62;KN-2 KN-2 (S)-4-(2-(N-methylisoquinoline-5-suNLFonamido)-3-oxo-3-(4-phenylpiperazin-1-yl)propyl)phenyl isoquinoline-5-suNLFonate N 62 KN 62; KN62 (1-(N,O-BIS-(5-ISOQUINOLINESULFONYL)-N-METHYL-L-TYROSYL)4-PHENYLPIPERAZINE) KN 62 (S)-5-Isoquinolinesulfonic acid 4-[2-[(5-isoquinolinylsulfonyl)methylamino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenyl ester, 1-[N,O-bis(5-Isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazine 4-[(2S)-2-[(5-Isoquinolinylsulfonyl)methylamino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl] phenylisoquinolinesulfonic acid ester 5-Isoquinolinesulfonic acid 4-[(S)-2-[[(isoquinolin-5-yl)sulfonyl]methylamino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenyl ester KN-62,97% 4-[(2S)-2-[(5-isoquinolinylsulfonyl)methylamino]-3-oxo- 3-(4-phenyl-1-piperazinyl)propyl]phenylisoquinolinesulfonicacid ester KN-62 (S)-4-(2-(N-methylisoquinoline-5-sulfonamido)-3-oxo-3-(4-phenylpiperazin-1-yl)propyl)phenyl isoquinoline-5-sulfonate (S)-4-(2-(N-Methylisoquinoline-5-sulfonaMido)-3-oxo-3-(4-phenylp KN-62, >=98% (S)-4-(2-(N-methylisoquinoline-5-sulfonamido)-3-oxo-3-(4-phenylpiperazin-1-yl)propyl)phenyl isoquinoline-5-sulfonat KN-62;KN 62; KN62 (S)-4-(2-(N-Methylisoquinoline-5-sulfonamido)-3-oxo-3-(4-phenylpiperazin-1-yl)propyl)phenyl is KN-62 4-[(2S)-2-[(5-ISOQUINOLINYLSULFONYL)METHYLAMINO]-3-OXO-3-(4-PHENYL-1-PIPERAZINYL)PROPYL] PHENYL ISOQUINOLINESULFONIC ACID ESTER 1-[N,O-BIS-(5-ISOQUINOLINESULFONYL)-N-METHYL-L-TYROSYL]-4-PHENYLPIPERAZINE 5-Isoquinolinesulfonicacid,4-[2-[(5-isoquinolinylsulfonyl)MethylaMino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenylester, (S)- (S)-5-ISOQUINOLINESULFONIC ACID 4-(2-[(5-ISOQUINOLINYLSULFONYL)METHYLAMINO]- 3-OXO-3-[4-PHENYL-1-PIPERAZINYL]PROPYL)PHENYL ESTER KN-62 USP/EP/BP [4-[(2S)-2-[isoquinolin-5-ylsulfonyl(methyl)amino]-3-oxo-3-(4-phenylpiperazin-1-yl)propyl]phenyl] isoquinoline-5-sulfonate noncompetitive antagonism,KN-62,KN 62,inhibit,P2XRs,Calmodulin-dependent protein kinases,HEK293 cells,P2X Receptor,Calmodulin-dependent kinases,CaMK,Inhibitor,autophosphorylation,KN62 KN-62, CaM kinase II inhibitor. P2X7 antagonist. KN-62 ，S7422 127191-97-3 C38H35O6S2 C38H35N5O6S2 Cell Biology Cell Signaling and Neuroscience Calcium/Calmodulin-Dependent Protein Kinase (CaMK) BioChemical Kinase/Phosphatase Biology Serine/Threonine Kinase Inhibitors Inhibitor Protein Kinase Protein Kinase Inhibitors and Activators