KN-62 | 127191-97-3

KN-62 Properties

Melting point	92-94°C
Boiling point	964.7±75.0 °C(Predicted)
Density	1.388
storage temp.	-20°C
solubility	45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.93 mg/mL
pka	4.07±0.13(Predicted)
form	solid
color	white
biological source	synthetic (organic)
InChIKey	RJVLFQBBRSMWHX-DHUJRADRSA-N
SMILES	O=S(OC1=CC=C(C[C@@H](C(N2CCN(C3=CC=CC=C3)CC2)=O)N(C)S(C4=CC=CC5=C4C=CN=C5)(=O)=O)C=C1)(C6=CC=CC7=C6C=CN=C7)=O
CAS DataBase Reference	127191-97-3(CAS DataBase Reference)
FDA UNII	63HM46XPOW
UNSPSC Code	12352200
NACRES	NA.77

SAFETY

Risk and Safety Statements

PPE	Eyeshields, Gloves, type N95 (US)
Safety Statements	24/25
WGK Germany	3
HS Code	29339980
Storage Class	11 - Combustible Solids

KN-62 price More Price(63)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	I2142	KN-62 ≥95%, powder	127191-97-3	0.5 mg	$146	2026-04-30	Buy
Sigma-Aldrich	I2142	KN-62 ≥95%, powder	127191-97-3	.5mg	$136	2025-07-31	Buy
Sigma-Aldrich	422706	KN-62	127191-97-3	1mg	$181	2023-01-07	Buy
Cayman Chemical	13318	KN-62 ≥98%	127191-97-3	1mg	$54	2026-04-30	Buy
Cayman Chemical	13318	KN-62 ≥98%	127191-97-3	5mg	$120	2026-04-30	Buy

Product number	Packaging	Price	Buy
I2142	0.5 mg	$146	Buy
I2142	.5mg	$136	Buy
422706	1mg	$181	Buy
13318	1mg	$54	Buy
13318	5mg	$120	Buy

KN-62 Chemical Properties, Uses, Production

Chemical Properties

Yellow Solid

Uses

A specific inhibitor of Ca2+/Calmodulin-dependent protein kinase II

Uses

selectively inhibits rat brain Ca2+/cadmodulin-dependent protein kinase II,

Uses

It is used as a potent and selective inhibitor of CaMKII. KN-62 has demonstrated potent and selective inhibition of Ca2+/calmodulin-dependent protein kinase II (CaMKII; Ki=0.9 M) which causes cells to arrest in the S phase. In HEK-293 cells expressing type III adenylyl cyclase (III-AC), 10 M of KN-62 blocked CaMKII phosphorylation of III-AC, and inhibited hormone-stimulated Ca2+ oscillations. Additionally, KN-62 is a potent non-competitive antagonist at the P2X7 receptor (IC50 = 15 nM).

Definition

ChEBI: 5-isoquinolinesulfonic acid [4-[(2S)-2-[5-isoquinolinylsulfonyl(methyl)amino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenyl] ester is a member of piperazines.

General Description

A cell-permeable, reversible, and selective inhibitor of CaM kinase II (K_i = 900 nM for rat brain CaM kinase II) that binds directly to the calmodulin binding site of the enzyme. Also inhibits the growth of K562 cells in a dose-dependent manner.

Biological Activity

Selective, cell-permeable inhibitor of CaM kinase II (IC 50 = 0.9 μ M). Binds directly to the calmodulin binding site of the enzyme. Potent non-competitive antagonist at the P2X 7 receptor (IC 50 = 15 nM). Also available as part of the Mixed Kinase Inhibitor Tocriset™ .

Biochem/physiol Actions

Selectively inhibits rat brain Ca2+/calmodulin-dependent protein kinase II.

storage

-20°C (desiccate)

KN-62 Preparation Products And Raw materials

Raw materials

Preparation Products

KN-62 Suppliers

Global Suppliers ( 208)

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69
Chembest Research Laboratories Limited	021-20908456	sales@BioChemBest.com	China	5996	61
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32273	50
BOC Sciences	1-631-485-4226; 16314854226	info@bocsci.com	United States	9920	65
Dalian Meilun Biotech Co., Ltd.	0411-62910999 13889544652	sales@meilune.com	China	4765	58
Thermo Fisher Scientific	800-810-5118	cnchemical@thermofisher.com	China	17752	75
NCE Biomedical Co.,Ltd.	4000-027-021 \|24 +86-13986109188 \| +86-15623472865 \| +81-08033611988		China	1490	55
Shanghai T&W Pharmaceutical Co., Ltd.	+86 21 61551611		China	9874	58

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
3B Pharmachem (Wuhan) International Co.,Ltd.	69
Chembest Research Laboratories Limited	61
Chemsky（shanghai）International Co.,Ltd.	50
BOC Sciences	65
Dalian Meilun Biotech Co., Ltd.	58
Thermo Fisher Scientific	75
NCE Biomedical Co.,Ltd.	55
Shanghai T&W Pharmaceutical Co., Ltd.	58

View Latest Price from KN-62 manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-07-27	KN-62 127191-97-3	$30.00-68.00		99.80%	10g	TargetMol Chemicals Inc.
2025-04-04	KN-62 127191-97-3		1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.
2020-02-01	KN-62 127191-97-3	$3.00	1KG	98%	100KG	Career Henan Chemical Co

KN-62
127191-97-3
$30.00-68.00
99.80%
TargetMol Chemicals Inc.

KN-62
127191-97-3
98%
Henan Aochuang Chemical Co.,Ltd.

KN-62
127191-97-3
$3.00
98%
Career Henan Chemical Co

KN-62 Spectrum

KN-62(127191-97-3)MS KN-62(127191-97-3)¹HNMR

127191-97-3 (KN-62) Related Search:

1-(3-Phenylpropyl)piperazine 1-Acetylpiperazine 4-Methyl-1-piperazineethanamine N-Aminoethylpiperazine 1-Acetyl-4-methylpiperazine hydrochloride

5-Isoquinolinesulfonic acid 1-(4-Phenylpiperazin-1-yl)ethanone N-[2-(4-Hydroxyphenyl)ethyl]-methanesulfonamide KN-62 1-(Propanoyl)-piperazine

1-Ethyl-4-phenylpiperazine 2-(4-Phenylpiperazin-1-yl)ethanamine N-phenethylmethanesulphonamide 1-Piperazineethanamine,N,4-dimethyl-(9CI) 1-(4-phenylpiperazin-1-yl)propan-2-amine

KN-62 **NOT FOR SALE IN JAPAN** KN-62: HBC COMPLEX

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1-(N,O-BIS-(5-ISOQUINOLINESULFONYL)-*N-M ETHYL-L-TYR KN-62 97% KN-62, 99+% 4-((2S)-2-((5-isoquinolinylsulfonyl)methylamino)-3-oxo-3-(4-phenyl-1-piperazinyl)propyl)phenylisoquinolinesulfonicacid 1-(N,O-Bis-[5-isoquinolinesulfonyl]-N-methyl-L-tyrosyl)-4-phenylpiperazine, (S)-5-Isoquinolinesulfonic Acid 4-(2-[(5-Isoquinolinylsulfonyl)methylamino]- 3-oxo-3-[4-phenyl-1-piperazinyl]propyl)phenyl Ester, 5-Isoquinolinesulfonic acid, 4-[(2S)-2-[(5-isoquinolinylsulfonyl)methylamino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenyl ester (s)-5-isoquinolinesulfonic acid 4-[2-[(5-isoquinolinylsulfonyl)methylamino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenyl ester CS-756 KN-62 - CAS 127191-97-3 - Calbiochem KN 62;KN-2 KN-2 (S)-4-(2-(N-methylisoquinoline-5-suNLFonamido)-3-oxo-3-(4-phenylpiperazin-1-yl)propyl)phenyl isoquinoline-5-suNLFonate N 62 KN 62; KN62 (1-(N,O-BIS-(5-ISOQUINOLINESULFONYL)-N-METHYL-L-TYROSYL)4-PHENYLPIPERAZINE) KN 62 (S)-5-Isoquinolinesulfonic acid 4-[2-[(5-isoquinolinylsulfonyl)methylamino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenyl ester, 1-[N,O-bis(5-Isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazine 4-[(2S)-2-[(5-Isoquinolinylsulfonyl)methylamino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl] phenylisoquinolinesulfonic acid ester 5-Isoquinolinesulfonic acid 4-[(S)-2-[[(isoquinolin-5-yl)sulfonyl]methylamino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenyl ester KN-62,97% 4-[(2S)-2-[(5-isoquinolinylsulfonyl)methylamino]-3-oxo- 3-(4-phenyl-1-piperazinyl)propyl]phenylisoquinolinesulfonicacid ester KN-62 (S)-4-(2-(N-methylisoquinoline-5-sulfonamido)-3-oxo-3-(4-phenylpiperazin-1-yl)propyl)phenyl isoquinoline-5-sulfonate (S)-4-(2-(N-Methylisoquinoline-5-sulfonaMido)-3-oxo-3-(4-phenylp KN-62, >=98% (S)-4-(2-(N-methylisoquinoline-5-sulfonamido)-3-oxo-3-(4-phenylpiperazin-1-yl)propyl)phenyl isoquinoline-5-sulfonat KN-62;KN 62; KN62 (S)-4-(2-(N-Methylisoquinoline-5-sulfonamido)-3-oxo-3-(4-phenylpiperazin-1-yl)propyl)phenyl is KN-62 4-[(2S)-2-[(5-ISOQUINOLINYLSULFONYL)METHYLAMINO]-3-OXO-3-(4-PHENYL-1-PIPERAZINYL)PROPYL] PHENYL ISOQUINOLINESULFONIC ACID ESTER 1-[N,O-BIS-(5-ISOQUINOLINESULFONYL)-N-METHYL-L-TYROSYL]-4-PHENYLPIPERAZINE 5-Isoquinolinesulfonicacid,4-[2-[(5-isoquinolinylsulfonyl)MethylaMino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl]phenylester, (S)- (S)-5-ISOQUINOLINESULFONIC ACID 4-(2-[(5-ISOQUINOLINYLSULFONYL)METHYLAMINO]- 3-OXO-3-[4-PHENYL-1-PIPERAZINYL]PROPYL)PHENYL ESTER KN-62 USP/EP/BP [4-[(2S)-2-[isoquinolin-5-ylsulfonyl(methyl)amino]-3-oxo-3-(4-phenylpiperazin-1-yl)propyl]phenyl] isoquinoline-5-sulfonate noncompetitive antagonism,KN-62,KN 62,inhibit,P2XRs,Calmodulin-dependent protein kinases,HEK293 cells,P2X Receptor,Calmodulin-dependent kinases,CaMK,Inhibitor,autophosphorylation,KN62 KN-62, CaM kinase II inhibitor. P2X7 antagonist. KN-62 ，S7422 127191-97-3 C38H35O6S2 C38H35N5O6S2 Cell Biology Cell Signaling and Neuroscience Calcium/Calmodulin-Dependent Protein Kinase (CaMK) BioChemical Kinase/Phosphatase Biology Serine/Threonine Kinase Inhibitors Inhibitor Protein Kinase Protein Kinase Inhibitors and Activators