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1-Acetyl-4-methylpiperazine hydrochloride

1-Acetyl-4-methylpiperazine hydrochloride Structure
1-Acetyl-4-methylpiperazine hydrochloride structure
CAS No.
60787-05-5
Chemical Name:
1-Acetyl-4-methylpiperazine hydrochloride
Synonyms
1-(4-Methylpiperazin-1-yl)ethan-1-one;1-Acetyl-4-methylpiperazineHCl;1-(4-methyl-1-piperazinyl)Ethanone;1-(4-Methylpiperazin-1-yl)ethanone;Ethanone, 1-(4-methyl-1-piperazinyl)-;1-Acetyl-4-methylpiperazine hydrochloride;1-Acetyl-4-methylpiperazine Hydrocholride
CBNumber:
CB3233029
Molecular Formula:
C7H14N2O
Molecular Weight:
142.2
MDL Number:
MFCD01195310
MOL File:
60787-05-5.mol
MSDS File:
SDS
Last updated:2026-09-12 18:51:51
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1-Acetyl-4-methylpiperazine hydrochloride Properties

Melting point 280 °C (decomp)
Boiling point 168 °C
Density 1.017±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
pka 6.84±0.10(Predicted)
Appearance Colorless to light yellow Liquid

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P301+P312-P302+P352-P304+P340-P305+P351+P338

1-Acetyl-4-methylpiperazine hydrochloride price More Price(25)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Synthonix M43876 1-(4-Methylpiperazin-1-yl)ethanone 97% 60787-05-5 100mg $53 2026-05-06 Buy
Synthonix M43876 1-(4-Methylpiperazin-1-yl)ethanone 97% 60787-05-5 250mg $58 2026-05-06 Buy
Synthonix M43876 1-(4-Methylpiperazin-1-yl)ethanone 97% 60787-05-5 1g $60 2026-05-06 Buy
Synthonix M43876 1-(4-Methylpiperazin-1-yl)ethanone 97% 60787-05-5 5g $390 2026-05-06 Buy
aablocks AA003DTT 1-(4-Methylpiperazin-1-Yl)Ethanone 98 60787-05-5 250mg $38 2026-05-28 Buy
Product number Packaging Price Buy
M43876 100mg $53 Buy
M43876 250mg $58 Buy
M43876 1g $60 Buy
M43876 5g $390 Buy
AA003DTT 250mg $38 Buy

1-Acetyl-4-methylpiperazine hydrochloride Chemical Properties, Uses, Production

Uses

1-Acetyl-4-methylpiperazine Hydrochloride is used in the preparation of (acetyl)piperazinium iodide and pyrrolopyrazinium iodides as nicotinic agonists.

Synthesis

1-Methylpiperazine

109-01-3

Acetic anhydride

108-24-7

1-ACETYL-4-METHYLPIPERAZINE HYDROCHLORIDE

60787-05-5

The general procedure for the synthesis of 1-acetyl-4-methylpiperazine from N-methylpiperazine and acetic anhydride was as follows: N-methylpiperazine (2.0 g, 19.97 mmol), triethylamine (3.35 mL, 23.96 mmol) and acetic anhydride (2.3 mL, 23.96 mmol) were dissolved in ethanol (60 mL) and the reaction was stirred at room temperature overnight. After completion of the reaction, the reaction mixture was concentrated to dryness under reduced pressure. The residue was purified by silica gel column chromatography using a mixed solvent of dichloromethane and methanol (with a gradient increase in the proportion of methanol) as eluent to afford the target product 1-acetyl-4-methylpiperazine (2.16 g, 76% yield) as a yellow oil. The product was characterized by 1H-NMR (CDCl3, 300 MHz) with chemical shifts δ: 3.65 (t, J = 6.8 Hz, 2H), 3.49 (t, J = 6.8 Hz, 2H), 2.46-2.39 (m, 4H), 2.32 (s, 3H), 2.10 (s, 3H) ppm.

References

[1] Patent: WO2014/6071, 2014, A1. Location in patent: Page/Page column 32
[2] Patent: EP2682391, 2014, A1. Location in patent: Paragraph 0112-0114

1-Acetyl-4-methylpiperazine hydrochloride Preparation Products And Raw materials

Raw materials

1-Methylpiperazine Acetic anhydride Triethylamine Ethanol

Preparation Products

1-Acetyl-4-methylpiperazine hydrochloride Suppliers

Global Suppliers ( 56)
Supplier Tel Email Country ProdList Advantage
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
ForeChem (Nantong) Technology Co.,Ltd. 513-85982855 18921614129 sales@xianxingpharm.com China 2712 61
VDM Biochemicals 0330-2528181 sales@vdmbio.com United States 510 64
Chengdu HappySyn Pharmaceutical Technology Co., Ltd. 85114309 18982182443 yangli@happysyn.com China 2297 55
Shanghai Aladdin Bio-Chem Technology Co.,LTD 400-6206333 13167063860 anhua.mao@aladdin-e.com China 29985 65
Shanghai Yolne Chemical Co., Ltd. 021-62960152 934678158@qq.com China 9886 55
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
EMMX Biotechnology LLC 888-539-0666 info@emmx.com United States 8435 60
Amadis Chemical Company Limited 571-89925085 sales@amadischem.com China 131885 58
Wuxi AppTec 022-59987777 13552403979 jia_guoqiang@wuxiapptec.com China 22344 58
Supplier Advantage
3B Pharmachem (Wuhan) International Co.,Ltd. 69
ForeChem (Nantong) Technology Co.,Ltd. 61
VDM Biochemicals 64
Chengdu HappySyn Pharmaceutical Technology Co., Ltd. 55
Shanghai Aladdin Bio-Chem Technology Co.,LTD 65
Shanghai Yolne Chemical Co., Ltd. 55
Bide Pharmatech Ltd. 60
EMMX Biotechnology LLC 60
Amadis Chemical Company Limited 58
Wuxi AppTec 58

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1-Acetyl-4-methylpiperazineHCl 1-Acetyl-4-methylpiperazine Hydrocholride 1-(4-Methylpiperazin-1-yl)ethanone 1-(4-methyl-1-piperazinyl)Ethanone Ethanone, 1-(4-methyl-1-piperazinyl)- 1-(4-Methylpiperazin-1-yl)ethan-1-one 1-Acetyl-4-methylpiperazine hydrochloride 60787-05-5 Cholinergics