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4-chloro-7-fluoro-quinazoline

4-chloro-7-fluoro-quinazoline Structure
4-chloro-7-fluoro-quinazoline structure
CAS No.
16499-62-0
Chemical Name:
4-chloro-7-fluoro-quinazoline
Synonyms
4-CHLORO-7-FLUORO-QUINAZOLINE;Quinazoline, 4-chloro-7-fluoro-
CBNumber:
CB8465166
Molecular Formula:
C8H4ClFN2
Molecular Weight:
182.58
MDL Number:
MFCD08236729
MOL File:
16499-62-0.mol
MSDS File:
SDS
Last updated:2026-05-28 03:31:51
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4-chloro-7-fluoro-quinazoline Properties

Boiling point 284.9±20.0 °C(Predicted)
Density 1.447
refractive index 1.635
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
pka 0.35±0.30(Predicted)
Appearance White to yellow Solid
InChI InChI=1S/C8H4ClFN2/c9-8-6-2-1-5(10)3-7(6)11-4-12-8/h1-4H
InChIKey JHBYQJRHJVEKPK-UHFFFAOYSA-N
SMILES N1=C2C(C=CC(F)=C2)=C(Cl)N=C1

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
HazardClass  IRRITANT
HS Code  2933998090

4-chloro-7-fluoro-quinazoline price More Price(46)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Apolloscientific PC905039 4-Chloro-7-fluoroquinazoline >98% 16499-62-0 1g $21 2026-06-04 Buy
Apolloscientific PC905039 4-Chloro-7-fluoroquinazoline >98% 16499-62-0 5g $58 2026-06-04 Buy
Apolloscientific PC905039 4-Chloro-7-fluoroquinazoline >98% 16499-62-0 25g $279 2026-06-04 Buy
Apolloscientific PC905039 4-Chloro-7-fluoroquinazoline >98% 16499-62-0 100g $1103 2026-06-04 Buy
Matrix Scientific 057322 4-Chloro-7-fluoroquinazoline 16499-62-0 1.00g $22 2026-05-18 Buy
Product number Packaging Price Buy
PC905039 1g $21 Buy
PC905039 5g $58 Buy
PC905039 25g $279 Buy
PC905039 100g $1103 Buy
057322 1.00g $22 Buy

4-chloro-7-fluoro-quinazoline Chemical Properties,Uses,Production

Description

4-chloro-7-fluoro-quinazoline is a white crystalline solid. It can be dissolved in organic solvents such as ethanol and dimethylformamide.

Synthesis

7-Fluoro-4-quinazolone

16499-57-3

4-chloro-7-fluoro-quinazoline

16499-62-0

General procedure for the synthesis of 4-chloro-7-fluoroquinazoline from 7-fluoro-4-quinazolinone: 7-fluoro-3H-quinazolin-4-one (8.2 g, 50 mmol) was mixed with thionyl chloride (80 mL) and the reaction was heated to reflux. After completion of the reaction, the excess thionyl chloride was removed by concentration under reduced pressure to give the target product 4-chloro-7-fluoroquinazoline (9.1 g, quantitative yield).

References

[1] Patent: US2008/70935, 2008, A1. Location in patent: Page/Page column 54
[2] Synthetic Communications, 2011, vol. 41, # 24, p. 3644 - 3653
[3] Journal of Medicinal Chemistry, 1996, vol. 39, # 1, p. 267 - 276
[4] Organic Letters, 2010, vol. 12, # 3, p. 552 - 555
[5] MedChemComm, 2014, vol. 5, # 9, p. 1290 - 1296

4-chloro-7-fluoro-quinazoline Preparation Products And Raw materials

Raw materials

7-Fluoro-4-quinazolone

Preparation Products

4-chloro-7-fluoro-quinazoline Suppliers

Global( 143)Suppliers
Supplier Tel Email Country ProdList Advantage
Nanjing Pope Bio-tech R&D Co., Ltd 025-87138562 18951783565 sales@popebiotech.com China 1180 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
ChemFuture PharmaTech (Jiangsu) Ltd 5108538618 suger.wang@chemfuture.com China 832 65
Carbott PharmTech Inc. 0535-6385396 info@carbottpharm.com China 996 56
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd. 21-57721279 18121011378 sales@shydchem.com.cn China 998 56
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418 sales@chemreagents.com United States 10174 62
Adamas Reagent, Ltd. 400-6009262 15618770481 yhx@titansci.com China 14098 59
Shanghai Paulshine Chemical Co., Ltd. +86-021-37788663 China 186 64
Nanjing Vital Chemical Co., Ltd. Please Send Email 18652950785 chemweiao@163.com China 4368 65
Supplier Advantage
Nanjing Pope Bio-tech R&D Co., Ltd 58
J & K SCIENTIFIC LTD. 76
ChemFuture PharmaTech (Jiangsu) Ltd 65
Carbott PharmTech Inc. 56
Capot Chemical Co., Ltd 66
Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd. 56
Pure Chemistry Scientific Inc. 62
Adamas Reagent, Ltd. 59
Shanghai Paulshine Chemical Co., Ltd. 64
Nanjing Vital Chemical Co., Ltd. 65

View Lastest Price from 4-chloro-7-fluoro-quinazoline manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-CHLORO-7-FLUORO-QUINAZOLINE pictures 2019-07-06 4-CHLORO-7-FLUORO-QUINAZOLINE
16499-62-0
 $1.00 1KG 95% 500KG Career Henan Chemical Co

4-chloro-7-fluoro-quinazoline Spectrum

4-chloro-7-fluoro-quinazoline(16499-62-0)1HNMR4-chloro-7-fluoro-quinazoline(16499-62-0)19FNMR

16499-62-0( 4-chloro-7-fluoro-quinazoline)Related Search:

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4-CHLORO-7-FLUORO-QUINAZOLINE Quinazoline, 4-chloro-7-fluoro- 16499-62-0 pharmacetical Halides CHIRAL CHEMICALS Fused Ring Systems