D-α-Tocopherol succinate
- CAS No.
- 4345-03-3
- Chemical Name:
- D-α-Tocopherol succinate
- Synonyms
- VE;VITAMIN E SUCCINATE;VES;TOCOPHEROL SUCCINATE;D-A-TOCOPHEROL SUCCINATE;D-alpha-Tocopheryl;α-Tocopheryl Succinate;D-ALPHA-TOCOPHERYL SUCCINATE;ALPHA-TOCOPHERYL SUCCINATE;D-ALPHA-TOCOPHEROL SUCCINATE
- CBNumber:
- CB8483476
- Molecular Formula:
- C33H54O5
- Molecular Weight:
- 530.78
- MDL Number:
- MFCD00072055
- MOL File:
- 4345-03-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | ~76 °C(lit.) |
|---|---|
| Boiling point | 625.8±55.0 °C(Predicted) |
| Density | 1.002±0.06 g/cm3(Predicted) |
| vapor pressure | 0Pa at 20℃ |
| storage temp. | -20°C |
| solubility | Practically insoluble in water, very soluble in methylene chloride, soluble in acetone and in anhydrous ethanol. |
| form | Solid |
| pka | 4.35±0.17(Predicted) |
| color | White or off-white |
| Odor | Little or no odor |
| biological source | synthetic |
| λmax | 286nm(EtOH)(lit.) |
| Merck | 14,9495 |
| BRN | 4038233 |
| Specific Activity | 1210IU/g |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. |
| Cosmetics Ingredients Functions | ANTIOXIDANT |
| InChIKey | IELOKBJPULMYRW-NJQVLOCASA-N |
| SMILES | CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC[C@]1(C)CCc2c(C)c(OC(=O)CCC(O)=O)c(C)c(C)c2O1 |
| LogP | 12 at 25℃ |
| CAS DataBase Reference | 4345-03-3(CAS DataBase Reference) |
| Substances Added to Food (formerly EAFUS) | ALPHA-TOCOPHEROL ACID SUCCINATE |
| EWG's Food Scores | 1 |
| FDA UNII | LU4B53JYVE |
| EPA Substance Registry System | D-.alpha.-Tocopheryl acid succinate (4345-03-3) |
| UNSPSC Code | 41116107 |
| NACRES | NA.79 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P301+P312-P302+P352-P304+P340-P305+P351+P338 |
| PPE | Eyeshields, Gloves, type N95 (US) |
| WGK Germany | 1 |
| RTECS | EJ9984000 |
| F | 8-10-23 |
| TSCA | TSCA listed |
| HS Code | 2936280000 |
| Storage Class | 11 - Combustible Solids |
| Toxicity | LD50 oral in rat: > 7gm/kg |
| REACH Registrations | Active |
D-α-Tocopherol succinate price More Price(42)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | T3126 | D-α-Tocopherol succinate semisynthetic, 1210?IU/g | 4345-03-3 | 5G | $65.5 | 2026-04-30 | Buy |
| Sigma-Aldrich | T3126 | D-α-Tocopherol succinate semisynthetic, 1210?IU/g | 4345-03-3 | 25G | $167 | 2026-04-30 | Buy |
| Sigma-Aldrich | T3126 | D-α-Tocopherol succinate semisynthetic, 1210?IU/g | 4345-03-3 | 100G | $485 | 2026-04-30 | Buy |
| Sigma-Aldrich | T1610000 | RRR-α-Tocopheryl hydrogen succinate European Pharmacopoeia (EP) Reference Standard | 4345-03-3 | 150 mg | $176 | 2026-04-30 | Buy |
| Sigma-Aldrich | PHR1029 | Tocopheryl Acid Succinate, a Pharmaceutical Secondary Standard; Certified Reference Material | 4345-03-3 | 500MG | $110 | 2026-04-30 | Buy |
D-α-Tocopherol succinate Chemical Properties, Uses, Production
Description
Tocopherol succinate (4345-03-3) is a potent antioxidant. Protects mice from gamma-radiation by induction of granulocyte-colony stimulating factor.1,2Tocopherol succinate induces apoptosis in human gastric cancer cells3and inhibits proliferation of mesothelioma cells by down-regulation of fibroblast growth factor receptor-14. Induces apoptosis in neuroblastoma cells.5
Chemical Properties
Off-White to Pale Yellow Solid
Uses
A potent antioxidant tocopherol
Uses
A potent novel antineoplastic agent with high selectivity and cooperativity with tumor necrosis factor-related apoptosis-inducing ligand (Apo2 ligand). It inhibits proliferation of mesothelioma cells by selective down-regulation of fibroblast growth factor receptors. Furthermore, it has been shown to enhance the anti-tumor effect of dendritic cell vaccines.
Definition
ChEBI: Tocopherol succinate is a tocol and a hemisuccinate.
General Description
White powder.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
Vitamin E succinate is an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.
Fire Hazard
Flash point data for Vitamin E succinate are not available; however, Vitamin E succinate is probably combustible.
Flammability and Explosibility
Not classified
Biochem/physiol Actions
Tocopherol exhibits antioxidant property by protecting the cells and membranes from oxidative stress. In plants, high levels of α-tocopherol leads to plant stress tolerance whereas low levels is associated with oxidative stress. In humans, tocopherol prevents cancer, premature aging, atherosclerosis, arthritis caused due to free radicals. Vitamin E succinate (VES) is an anti-tumor analog of vitamin E.
Safety Profile
When heated to decomposition it emits acrid smoke and irritating fumes.
References
[1] VIJAY K SINGH Tzu C K Darren S Brown. Alpha-tocopherol succinate protects mice from gamma-radiation by induction of granulocyte-colony stimulating factor.[J]. International Journal of Radiation Biology, 2010, 86 1: 12-21. DOI:10.3109/09553000903264515
[2] VIJAY K. SINGH Tzu C K Darren S Brown. Tocopherol succinate: A promising radiation countermeasure[J]. International immunopharmacology, 2009, 9 12: Pages 1423-1430. DOI:10.1016/j.intimp.2009.08.020
[3] KUN WU. c-Jun N-terminal kinase is required for vitamin E succinate-induced apoptosis in human gastric cancer cells.[J]. World Journal of Gastroenterology, 2004, 10 8: 1110-1114. DOI:10.3748/wjg.v10.i8.1110
[4] MICHAEL STAPELBERG. alpha-Tocopheryl succinate inhibits proliferation of mesothelioma cells by selective down-regulation of fibroblast growth factor receptors.[J]. Biochemical and biophysical research communications, 2004, 69 1: 636-641. DOI:10.1016/s0006-291x(04)00797-1
[5] EMMA SWETTENHAM. α-Tocopheryl succinate selectively induces apoptosis in neuroblastoma cells: potential therapy of malignancies of the nervous system[J]. Journal of Neurochemistry, 2005, 94 5: 1448-1456. DOI:10.1111/j.1471-4159.2005.03298.x
D-α-Tocopherol succinate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Zhentian Food Additives Co., Ltd. | 0551-77777777-5 13333333333 | China | 9996 | 58 | |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Beijing HwrkChemical Technology Co., Ltd | 89508211 18501085097 | sales.bj@hwrkchemical.com | China | 9407 | 55 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| Tianjin heowns Biochemical Technology Co., Ltd. | 400 638 7771 | sales@heowns.com | China | 14412 | 57 |
| Hunan Hui Bai Shi Biotechnology Co., Ltd. | 0731-85526065 13308475853 | ivy@hnhbsj.com | China | 7236 | 62 |
| Beijing Taiya Jie Technology Development Co., Ltd. | 021-33690831-8001 13552411790;18616022633 | postmaster@tyjchem.cn | China | 1541 | 55 |
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View Latest Price from D-α-Tocopherol succinate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-15 | D-α-Tocopherol succinate
4345-03-3
|
1KG | 98%min | 30tons/month | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-09-10 | Vitamin E succinate
4345-03-3
|
$30.00-77.00 | 99.24% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-08-07 | D-α-Tocopherol succinate
4345-03-3
|
$1.00-4.00 | 1KG | 99% | 200000KG | Shaanxi Dideu Medichem Co. Ltd |
-
- D-α-Tocopherol succinate
4345-03-3
- $0.00
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Vitamin E succinate
4345-03-3
- $30.00-77.00
- 99.24%
- TargetMol Chemicals Inc.
-
- D-α-Tocopherol succinate
4345-03-3
- $1.00-4.00
- 99%
- Shaanxi Dideu Medichem Co. Ltd
