(7S)-6-(Cyclopropylmethyl)-2-(2,4-dichlorophenyl)-7-ethyl-7,8-dihydro-4-methyl-6H-1,3,6,8a-tetraazaacenaphthylene hydrochloride
- CAS No.
- 1782228-59-4
- Chemical Name:
- (7S)-6-(Cyclopropylmethyl)-2-(2,4-dichlorophenyl)-7-ethyl-7,8-dihydro-4-methyl-6H-1,3,6,8a-tetraazaacenaphthylene hydrochloride
- Synonyms
- (7S)-6-(Cyclopropylmethyl)-2-(2,4-dichlorophenyl)-7-ethyl-7,8-dihydro-4-methyl-6H-1,3,6,8a-tetraazaacenaphthylene hydrochloride
- CBNumber:
- CB84902571
- Molecular Formula:
- C21H23Cl3N4
- Molecular Weight:
- 437.79
- MDL Number:
- MOL File:
- 1782228-59-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P280-P305+P351+P338 |
(7S)-6-(Cyclopropylmethyl)-2-(2,4-dichlorophenyl)-7-ethyl-7,8-dihydro-4-methyl-6H-1,3,6,8a-tetraazaacenaphthylene hydrochloride price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 460605 | NBI 35965 Hydrochloride | 1782228-59-4 | 1mg | $523 | 2026-06-03 | Buy |
| ChemScene | CS-0032882 | NBI 35965 hydrochloride 98% | 1782228-59-4 | 5mg | $437 | 2026-06-04 | Buy |
| ChemScene | CS-0032882 | NBI 35965 hydrochloride 98% | 1782228-59-4 | 10mg | $699 | 2026-06-04 | Buy |
| Arctom | HY-110056 | NBI 35965 hydrochloride | 1782228-59-4 | 5mg | $383 | 2026-05-26 | Buy |
| Arctom | HY-110056 | NBI 35965 hydrochloride | 1782228-59-4 | 10mg | $613 | 2026-05-26 | Buy |
(7S)-6-(Cyclopropylmethyl)-2-(2,4-dichlorophenyl)-7-ethyl-7,8-dihydro-4-methyl-6H-1,3,6,8a-tetraazaacenaphthylene hydrochloride Chemical Properties, Uses, Production
Uses
NBI 35965 Hydrochloride is a potent and selective corticotropin-releasing factor 1 (CRF1) antagonist.
in vivo
NBI 35965 hydrochloride (20 mg/kg; oral gavage; once) reduces stress induced ACTH production in mice[1].
In rats, NBI 35965 hydrochloride (Compound 12a; 10 mg/kg) has a volume of distribution 17.8 L/kg, a plasma clearance of 17 mL/min/kg, and a half-life of 12 h. The estimated oral bioavailability is 34% with a mean maximal plasma concentration at 1 h of 560 ng/mL. NBI 35965 hydrochloride also penetrated the blood-brain barrier, resulting in a mean maximal brain concentration of 700 ng/g[1].
| Animal Model: | Male CD-1 mice (24-26 g) bearing restraint stress[1] |
| Dosage: | 20 mg/kg (10 mL/kg 5% mannitol-d (w/v) in water) |
| Administration: | Oral gavage; 60 min prior to the initiation of the stressor |
| Result: | Reduced stress induced ACTH production in vivo. |
IC 50
CRFR1: 4 nM (Ki); CRFR1: 8.5 (pKi)
storage
Desiccate at RT
(7S)-6-(Cyclopropylmethyl)-2-(2,4-dichlorophenyl)-7-ethyl-7,8-dihydro-4-methyl-6H-1,3,6,8a-tetraazaacenaphthylene hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
(7S)-6-(Cyclopropylmethyl)-2-(2,4-dichlorophenyl)-7-ethyl-7,8-dihydro-4-methyl-6H-1,3,6,8a-tetraazaacenaphthylene hydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 50089 | 58 |
| Supplier | Advantage |
|---|---|
| BOC Sciences | 65 |
| TargetMol Chemicals Inc. | 58 |
| Aladdin Scientific | 58 |
