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4-CHLORO-2-METHYLTHIOPYRAZOLO[1,5-A]1,3,5-TRIAZINE

4-CHLORO-2-METHYLTHIOPYRAZOLO[1,5-A]1,3,5-TRIAZINE structure

CAS No.: 54346-19-9

Chemical Name:: 4-CHLORO-2-METHYLTHIOPYRAZOLO[1,5-A]1,3,5-TRIAZINE

Synonyms: 5-a][1;pyrazolo[1,5-a][1,3,5]triazine;4-chloro-2-(Methylthio)pyrazolo[1;4-CHLORO-2-METHYLTHIOPYRAZOLO[1,5-A]1,3,5-TRIAZINE;Pyrazolo[1,5-a]-1,3,5-triazine, 4-chloro-2-(methylthio)-;4-Chloro-2-methylsulfanyl-pyrazolo[1,5-a][1,3,5]triazine;4-chloro-2-(methylthio)-1,2-dihydropyrazolo[1,5-a][1,3,5]triazine

CBNumber:: CB8494476

Molecular Formula:: C6H5ClN4S

Molecular Weight:: 200.65

MDL Number:: MFCD08275129

MOL File:: 54346-19-9.mol

MSDS File:: SDS

Last updated:2026-05-28 05:36:13

Request For Quotation

4-CHLORO-2-METHYLTHIOPYRAZOLO[1,5-A]1,3,5-TRIAZINE Properties

Density	1.67±0.1 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
pka	-1.84±0.30(Predicted)
Appearance	Light yellow to yellow Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P264-P270-P301+P312-P330-P501-P280-P302+P352-P321-P332+P313-P362-P305+P351+P338-P337+P313-P261-P271-P304+P340-P312-P403+P233-P405

4-CHLORO-2-METHYLTHIOPYRAZOLO[1,5-A]1,3,5-TRIAZINE price More Price(37)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
AstaTech	57384	4-CHLORO-2-METHYLSULFANYL-PYRAZOLO[1,5-A][1,3,5]TRIAZINE 95%	54346-19-9	0.25G	$67	2026-04-30	Buy
AstaTech	57384	4-CHLORO-2-METHYLSULFANYL-PYRAZOLO[1,5-A][1,3,5]TRIAZINE 95%	54346-19-9	1G	$200	2026-04-30	Buy
Matrix Scientific	069164	4-Chloro-2-(methylthio)pyrazolo[1,5-a][1,3,5]triazine	54346-19-9	1.00g	$1172	2026-05-18	Buy
Matrix Scientific	069164	4-Chloro-2-(methylthio)pyrazolo[1,5-a][1,3,5]triazine	54346-19-9	5.00g	$4463	2026-05-18	Buy
Synthonix	C1069	4-Chloro-2-(methylthio)pyrazolo[1,5-a][1,3,5]triazine 95%+	54346-19-9	100mg	$27	2026-05-06	Buy

Product number	Packaging	Price	Buy
57384	0.25G	$67	Buy
57384	1G	$200	Buy
069164	1.00g	$1172	Buy
069164	5.00g	$4463	Buy
C1069	100mg	$27	Buy

4-CHLORO-2-METHYLTHIOPYRAZOLO[1,5-A]1,3,5-TRIAZINE Chemical Properties,Uses,Production

Synthesis

2-(METHYLTHIO)PYRAZOLO[1,5-A][1,3,5]TRIAZIN-4(3H)-ONE

54346-18-8

4-CHLORO-2-METHYLTHIOPYRAZOLO[1,5-A]1,3,5-TRIAZINE

54346-19-9

The general procedure for the synthesis of 4-chloro-2-(methylthio)pyrazolo[1,5-alpha][1,3,5]triazin-4(3H)-one from 2-(methylthio)pyrazolo[1,5-α][1,3,5]triazin-4(3H)-one was as follows: to a stirred suspension of 2-(methylthio)pyrazolo[1,5-alpha][1,3,5]triazin-4(3H)-one (2.0 g. 11 mmol) and a suspension of trichlorophosphorus (20 mL) was added to N,N-diethylaniline (0.7 mL). The reaction mixture was heated to reflux temperature. After 1.5 hours of reaction, the mixture was cooled to room temperature and concentrated under reduced pressure. The residue was dissolved in toluene and the organic layer was washed with brine and concentrated again under reduced pressure to give 4-chloro-2-(methylthio)pyrazolo[1,5-a][1,3,5]triazine (2.0 g, 91% yield).TLC Rf = 0.57 (ethyl acetate/hexane, 1/3); 1H NMR (300 MHz, CDCl3) δ 8.15 (d, J = 2.2Hz , 1H), 6.50 (d, J = 2.2 Hz, 1H), 2.60 (s, 3H).

References

[1] Bioorganic and Medicinal Chemistry, 2011, vol. 19, # 20, p. 5955 - 5966
[2] Patent: US2007/78136, 2007, A1. Location in patent: Page/Page column 50
[3] Patent: WO2011/31979, 2011, A1. Location in patent: Page/Page column 147
[4] Patent: US9303033, 2016, B2. Location in patent: Page/Page column 285; 286
[5] Patent: JP5802676, 2015, B2. Location in patent: Paragraph 0552

4-CHLORO-2-METHYLTHIOPYRAZOLO[1,5-A]1,3,5-TRIAZINE synthesis

Synthesis of 4-CHLORO-2-METHYLTHIOPYRAZOLO[1,5-A]1,3,5-TRIAZINE from 2-(METHYLTHIO)PYRAZOLO[1,5-A][1,3,5]TRIAZIN-4(3H)-ONE

4-CHLORO-2-METHYLTHIOPYRAZOLO[1,5-A]1,3,5-TRIAZINE Preparation Products And Raw materials

Raw materials

Ethoxycarbonyl Isothiocyanate 3-Aminopyrazole Ethanol Phosphorus oxitrichloride N,N-Dimethylaniline

Benzene Ethyl acetate Sodium hydroxide Iodomethane Sulfuric acid

ethyl 2H-pyrazol-3-ylaMinocarbothioylcarbaMate 2-Thioxo-2,3-dihydropyrazolo[1,5-a][1,3,5]triazin-4(1H)-one 2-(METHYLTHIO)PYRAZOLO[1,5-A][1,3,5]TRIAZIN-4(3H)-ONE

1of3

Preparation Products

8-BROMO-4-CHLORO-2-METHYLTHIOPYRAZOLO[1,5-A]1,3,5-TRIAZINE

4-CHLORO-2-METHYLTHIOPYRAZOLO[1,5-A]1,3,5-TRIAZINE Suppliers

Global( 91)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
Jia Xing Isenchem Co.,Ltd	0573-85285100 18627885956	isenchem@163.com	China	9389	66
Shangchem Co., Ltd.	+86-21-68182121		China	881	52
Pure Chemistry Scientific Inc.	001-857-928-2050 or 1-888-588-9418	sales@chemreagents.com	United States	10174	62
skychemical Co.Ltd	021-20958197 20965099	sales@skychemical.com	China	1182	57
Shanghai Keepontech Co.,Ltd	021-54849683 13601642561	sales@keepontech.com	China	997	59
SYN\|thesis med chem P/L	+86-021-50720296	service@synkinase.com	China	266	58
Bsisun HK Imoprt And Export Company Limited	+86-18068513926		China	1273	55
Wuhan Kaymke Chemical Co., Ltd.,	027-87342388 18086026008	sales@kaymke.com	China	3544	55

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
Capot Chemical Co., Ltd	66
Jia Xing Isenchem Co.,Ltd	66
Shangchem Co., Ltd.	52
Pure Chemistry Scientific Inc.	62
skychemical Co.Ltd	57
Shanghai Keepontech Co.,Ltd	59
SYN\|thesis med chem P/L	58
Bsisun HK Imoprt And Export Company Limited	55
Wuhan Kaymke Chemical Co., Ltd.,	55

View Lastest Price from 4-CHLORO-2-METHYLTHIOPYRAZOLO[1,5-A]1,3,5-TRIAZINE manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2020-01-09	4-CHLORO-2-METHYLTHIOPYRAZOLO[1,5-A]1,3,5-TRIAZINE 54346-19-9	$9.80	1g	≥99%	100kg	Career Henan Chemical Co
	2020-01-09	4-CHLORO-2-METHYLTHIOPYRAZOLO[1,5-A]1,3,5-TRIAZINE 54346-19-9	$1.00	1KG	95-99%	1ton	Career Henan Chemical Co

4-CHLORO-2-METHYLTHIOPYRAZOLO[1,5-A]1,3,5-TRIAZINE
54346-19-9
$9.80
≥99%
Career Henan Chemical Co

4-CHLORO-2-METHYLTHIOPYRAZOLO[1,5-A]1,3,5-TRIAZINE
54346-19-9
$1.00
95-99%
Career Henan Chemical Co

4-CHLORO-2-METHYLTHIOPYRAZOLO[1,5-A]1,3,5-TRIAZINE Spectrum

4-CHLORO-2-METHYLTHIOPYRAZOLO[1,5-A]1,3,5-TRIAZINE(54346-19-9)¹HNMR

54346-19-9(4-CHLORO-2-METHYLTHIOPYRAZOLO[1,5-A]1,3,5-TRIAZINE)Related Search:

8-BROMO-4-CHLORO-2-METHYLTHIOPYRAZOLO[1,5-A]1,3,5-TRIAZINE 4-CHLORO-2-METHYLTHIOPYRAZOLO[1,5-A]1,3,5-TRIAZINE

4-CHLORO-2-METHYLTHIOPYRAZOLO[1,5-A]1,3,5-TRIAZINE 4-Chloro-2-methylsulfanyl-pyrazolo[1,5-a][1,3,5]triazine 4-chloro-2-(Methylthio)pyrazolo[1 5-a][1 4-chloro-2-(methylthio)-1,2-dihydropyrazolo[1,5-a][1,3,5]triazine pyrazolo[1,5-a][1,3,5]triazine Pyrazolo[1,5-a]-1,3,5-triazine, 4-chloro-2-(methylthio)- 54346-19-9 C6H5ClN4S CHIRAL CHEMICALS