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| | 4-CHLORO-2-METHYLTHIOPYRAZOLO[1,5-A]1,3,5-TRIAZINE Basic information |
| Product Name: | 4-CHLORO-2-METHYLTHIOPYRAZOLO[1,5-A]1,3,5-TRIAZINE | | Synonyms: | 4-CHLORO-2-METHYLTHIOPYRAZOLO[1,5-A]1,3,5-TRIAZINE;4-Chloro-2-methylsulfanyl-pyrazolo[1,5-a][1,3,5]triazine;4-chloro-2-(Methylthio)pyrazolo[1;5-a][1;4-chloro-2-(methylthio)-1,2-dihydropyrazolo[1,5-a][1,3,5]triazine;pyrazolo[1,5-a][1,3,5]triazine;Pyrazolo[1,5-a]-1,3,5-triazine, 4-chloro-2-(methylthio)- | | CAS: | 54346-19-9 | | MF: | C6H5ClN4S | | MW: | 200.65 | | EINECS: | 200-589-5 | | Product Categories: | CHIRAL CHEMICALS | | Mol File: | 54346-19-9.mol | ![4-CHLORO-2-METHYLTHIOPYRAZOLO[1,5-A]1,3,5-TRIAZINE Structure](CAS/GIF/54346-19-9.gif) |
| | 4-CHLORO-2-METHYLTHIOPYRAZOLO[1,5-A]1,3,5-TRIAZINE Chemical Properties |
| density | 1.67±0.1 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | pka | -1.84±0.30(Predicted) | | Appearance | Light yellow to yellow Solid |
| | 4-CHLORO-2-METHYLTHIOPYRAZOLO[1,5-A]1,3,5-TRIAZINE Usage And Synthesis |
| Synthesis | The general procedure for the synthesis of 4-chloro-2-(methylthio)pyrazolo[1,5-alpha][1,3,5]triazin-4(3H)-one from 2-(methylthio)pyrazolo[1,5-α][1,3,5]triazin-4(3H)-one was as follows: to a stirred suspension of 2-(methylthio)pyrazolo[1,5-alpha][1,3,5]triazin-4(3H)-one (2.0 g. 11 mmol) and a suspension of trichlorophosphorus (20 mL) was added to N,N-diethylaniline (0.7 mL). The reaction mixture was heated to reflux temperature. After 1.5 hours of reaction, the mixture was cooled to room temperature and concentrated under reduced pressure. The residue was dissolved in toluene and the organic layer was washed with brine and concentrated again under reduced pressure to give 4-chloro-2-(methylthio)pyrazolo[1,5-a][1,3,5]triazine (2.0 g, 91% yield).TLC Rf = 0.57 (ethyl acetate/hexane, 1/3); 1H NMR (300 MHz, CDCl3) δ 8.15 (d, J = 2.2Hz , 1H), 6.50 (d, J = 2.2 Hz, 1H), 2.60 (s, 3H). | | References | [1] Bioorganic and Medicinal Chemistry, 2011, vol. 19, # 20, p. 5955 - 5966
[2] Patent: US2007/78136, 2007, A1. Location in patent: Page/Page column 50
[3] Patent: WO2011/31979, 2011, A1. Location in patent: Page/Page column 147
[4] Patent: US9303033, 2016, B2. Location in patent: Page/Page column 285; 286
[5] Patent: JP5802676, 2015, B2. Location in patent: Paragraph 0552 |
| | 4-CHLORO-2-METHYLTHIOPYRAZOLO[1,5-A]1,3,5-TRIAZINE Preparation Products And Raw materials |
| Raw materials | Ethanol-->Sodium hydroxide-->Ethyl acetate-->Sulfuric acid-->Phosphorus oxitrichloride-->Benzene-->Iodomethane-->N,N-Dimethylaniline-->3-Aminopyrazole-->Ethoxycarbonyl Isothiocyanate-->ethyl 2H-pyrazol-3-ylaMinocarbothioylcarbaMate-->2-Thioxo-2,3-dihydropyrazolo[1,5-a][1,3,5]triazin-4(1H)-one-->2-(METHYLTHIO)PYRAZOLO[1,5-A][1,3,5]TRIAZIN-4(3H)-ONE | | Preparation Products | 8-BROMO-4-CHLORO-2-METHYLTHIOPYRAZOLO[1,5-A]1,3,5-TRIAZINE |
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