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ChemicalBook >> CAS DataBase List >>4-oxo-27-TBDMS Withaferin A

4-oxo-27-TBDMS Withaferin A

4-oxo-27-TBDMS Withaferin A Structure
4-oxo-27-TBDMS Withaferin A structure
CAS No.
1214886-31-3
Chemical Name:
4-oxo-27-TBDMS Withaferin A
Synonyms
4-oxo-27-TBDMS Withaferin A;(5β,6β,22R)-27-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5,6-epoxy-22-hydroxy-1,4-dioxo-ergosta-2,24-dien-26-oic acid, δ-lactone;Ergosta-2,24-dien-26-oic acid, 27-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5,6-epoxy-22-hydroxy-1,4-dioxo-, δ-lactone, (5β,6β,22R)-
CBNumber:
CB85540932
Molecular Formula:
C34H50O6Si
Molecular Weight:
582.85
MDL Number:
MOL File:
1214886-31-3.mol
MSDS File:
SDS
Last updated:2026-05-28 05:54:43
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4-oxo-27-TBDMS Withaferin A Properties

Boiling point 651.3±55.0 °C(Predicted)
Density 1.14±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF: 5mg/mL; DMSO: 5mg/mL; DMSO:PBS (pH 7.2) (1:1): 0.5mg/mL

SAFETY

Risk and Safety Statements

Symbol(GHS)  Flame (GHS02)Exclamation Mark (GHS07)
GHS02,GHS07
Signal word  Danger
Hazard statements  H225-H319
Precautionary statements  P210-P233-P240-P241-P242-P243-P264-P280-P303+P361+P353-P305+P351+P338-P337+P313-P370+P378-P403+P235-P501
NFPA 704
3
2 0

4-oxo-27-TBDMS Withaferin A price More Price(8)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 28323 4-oxo-27-TBDMS Withaferin A ≥98% 1214886-31-3 1mg $90 2026-04-30 Buy
Cayman Chemical 28323 4-oxo-27-TBDMS Withaferin A ≥98% 1214886-31-3 5mg $262 2026-04-30 Buy
Cayman Chemical 28323 4-oxo-27-TBDMS Withaferin A ≥98% 1214886-31-3 10mg $436 2026-04-30 Buy
Biosynth PYB88631 4-Oxo-27-TBDMS withaferin A 1214886-31-3 5mg $843.7 2026-06-04 Buy
Biosynth PYB88631 4-Oxo-27-TBDMS withaferin A 1214886-31-3 10mg $1349.9 2026-06-04 Buy
Product number Packaging Price Buy
28323 1mg $90 Buy
28323 5mg $262 Buy
28323 10mg $436 Buy
PYB88631 5mg $843.7 Buy
PYB88631 10mg $1349.9 Buy

4-oxo-27-TBDMS Withaferin A Chemical Properties, Uses, Production

Description

4-oxo-27-TBDMS Withaferin A is a derivative of the steroidal lactone withaferin A that has anticancer activity.1 It is cytotoxic to A2780 ovarian cancer cells (IC50 = 17 μM) but not to carboplatin-resistant A2780 (A2780/CP70) cells (IC50 = >100 μM). It is selective for A2780 cells over non-cancerous ARPE19 cells (IC50 = 1,660 μM). 4-oxo-27-TBDMS Withaferin A induces DNA fragmentation in A2780 cells.

Uses

27-TBDMS-4-Dehydrowithaferin A, a withaferin A derivative, exhibits potent antiproliferative effects on the tumor cells.27-TBDMS-4-Dehydrowithaferin A induces tumor cells apoptosis. 27-TBDMS-4-Dehydrowithaferin A is a anticancer agent[1].

References

1. Perestelo, N.R., Llanos, G.G., Reyes, C.P., et al. Expanding the chemical space of withaferin A by incorporating silicon to improve its clinical potential on human ovarian carcinoma cells J. Med. Chem. 62(9),4571-4585(2019).

4-oxo-27-TBDMS Withaferin A Preparation Products And Raw materials

Raw materials

Preparation Products

4-oxo-27-TBDMS Withaferin A Suppliers

Global Suppliers ( 12)
Supplier Tel Email Country ProdList Advantage
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 400-920-5774 sales@glpbio.cn China 6705 58
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11123 58
Beijing Biocreative Technology Co., Ltd. 15522676233 3007606172@qq.com China 1246 58
Shanghai Yiyan Biotechnology Co. , Ltd. 021-69985186 13611928337 3427709316@qq.com China 7982 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11963 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29874 58
Supplier Advantage
Shanghai Hongye Biotechnology Co. Ltd 58
TargetMol Chemicals Inc. 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Beijing Biocreative Technology Co., Ltd. 58
Shanghai Yiyan Biotechnology Co. , Ltd. 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
TargetMol Chemicals Inc. 58

View Latest Price from 4-oxo-27-TBDMS Withaferin A manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-oxo-27-TBDMS Withaferin A pictures 2026-05-11 4-oxo-27-TBDMS Withaferin A
1214886-31-3
 $287.00-1430.00 10g TargetMol Chemicals Inc.

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4-oxo-27-TBDMS Withaferin A Ergosta-2,24-dien-26-oic acid, 27-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5,6-epoxy-22-hydroxy-1,4-dioxo-, δ-lactone, (5β,6β,22R)- (5β,6β,22R)-27-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5,6-epoxy-22-hydroxy-1,4-dioxo-ergosta-2,24-dien-26-oic acid, δ-lactone 1214886-31-3