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4-Bromomethyl-2-chloro-1-methoxybenzene

4-Bromomethyl-2-chloro-1-methoxybenzene Structure
4-Bromomethyl-2-chloro-1-methoxybenzene structure
CAS No.
320407-92-9
Chemical Name:
4-Bromomethyl-2-chloro-1-methoxybenzene
Synonyms
RSYY（Avanafil)-58;-2-chloro-1-methoxybenzene;3-Chloro-4-Methoxybenzyl broMide;4-bromethyl-2-chloro-1-methoxybenzene;4-Bromomethyl-2-chloro-1-methoxybenzene;Benzene, 4-(bromomethyl)-2-chloro-1-methoxy-
CBNumber:
CB8676104
Molecular Formula:
C8H8BrClO
Molecular Weight:
235.51
MDL Number:
MFCD06858766
MOL File:
320407-92-9.mol
MSDS File:
SDS
Last updated:2026-09-12 18:55:49
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4-Bromomethyl-2-chloro-1-methoxybenzene Properties

Boiling point 273.0±25.0 °C(Predicted)
Density 1.520±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
Appearance White to off-white Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302+H312+H332-H315-H319-H335
Precautionary statements  P261-P280-P305+P351+P338
RIDADR  UN3261
HazardClass  8
HS Code  2909309090
Limited Quantities 1.0 L (0.3 gallons) (liquid) or 1 Kg (2.2 lbs) (solid)
Excepted Quantities Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml)

4-Bromomethyl-2-chloro-1-methoxybenzene price More Price(52)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Usbiological 263999 4-Bromomethyl-2-chloro-1-methoxybenzene Asreported 320407-92-9 1g $465 2026-06-03 Buy
Usbiological 263999 4-Bromomethyl-2-chloro-1-methoxybenzene Asreported 320407-92-9 2g $664 2026-06-03 Buy
Usbiological 263999 4-Bromomethyl-2-chloro-1-methoxybenzene Asreported 320407-92-9 5g $1031 2026-06-03 Buy
Usbiological 263999 4-Bromomethyl-2-chloro-1-methoxybenzene Asreported 320407-92-9 10g $1493 2026-06-03 Buy
Usbiological 263999 4-Bromomethyl-2-chloro-1-methoxybenzene Asreported 320407-92-9 25g $2428 2026-06-03 Buy
Product number Packaging Price Buy
263999 1g $465 Buy
263999 2g $664 Buy
263999 5g $1031 Buy
263999 10g $1493 Buy
263999 25g $2428 Buy

4-Bromomethyl-2-chloro-1-methoxybenzene Chemical Properties, Uses, Production

Synthesis

3-CHLORO-4-METHOXYTOLUENE

22002-44-4

4-BROMOMETHYL-2-CHLORO-1-METHOXYBENZENE

320407-92-9

General procedure for the synthesis of 4-bromomethyl-2-chloro-1-methoxybenzene from 2-chloro-1-methoxy-4-methylbenzene: 2-chloro-1-methoxy-4-methylbenzene (2.6 mL, 19.2 mmol) was dissolved in dichloromethane (30 mL) and N-bromosuccinimide (3.75 g, 21.1 mmol) and AIBN (36.0 mg). The reaction mixture was heated to reflux, kept for 19 h and then cooled to room temperature and filtered to remove the precipitate. The filtrate was diluted with dichloromethane and washed sequentially with 0.5 M aqueous sodium bicarbonate and water. The organic phase was dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give 4-bromomethyl-2-chloro-1-methoxybenzene (4.73 g, 82% yield). The crude product (benzyl bromide) could be used for subsequent reaction without further purification.1H NMR (400 MHz, CDCl3): δ 7.42 (d, 1H, J = 2.4 Hz), 7.26 (dd, 1H, J = 2.4 Hz, J = 8.4 Hz), 6.88 (d, 1H, J = 8.4 Hz), 4.44 (s, 2H), 3.90 (s. 3H).

References

[1] Patent: US2002/169174, 2002, A1
[2] European Journal of Organic Chemistry, 2005, # 2, p. 317 - 325
[3] Patent: WO2012/7868, 2012, A2. Location in patent: Page/Page column 94-95
[4] Patent: US2007/88053, 2007, A1. Location in patent: Page/Page column 19

4-Bromomethyl-2-chloro-1-methoxybenzene Preparation Products And Raw materials

Raw materials

3-Chloro-4-methoxytoluene Water N-Bromosuccinimide AIBN

Preparation Products

4-Bromomethyl-2-chloro-1-methoxybenzene Suppliers

Global Suppliers ( 64)
Supplier Tel Email Country ProdList Advantage
Shanghai Sunway Pharmaceutical Technology Co., Ltd 13761987713 hxzheng@sunwaypharm.cn China 8663 57
SynAsst Chemical. 021-60343070 China 12731 55
Shanghai Raise Chemical Technology Co.,Ltd +86-021-50935922 China 7854 55
Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd. +86-28-85122536 85324413 market@astatech.cn China 8016 55
Cool Pharm, Ltd 021-60455363 18019463053 sales@coolpharm.com China 8455 58
Zhengzhou Alfachem Co., Ltd. 0371-53765687 18937137882 3969243885@qq.com China 7734 55
Amadis Chemical Company Limited 571-89925085 sales@amadischem.com China 131885 58
Shanghai CR Corporation Limited 13917420128 13062833949 fred.wen@crcorporation.cn China 9776 58
Hangzhou Molcore Biopharmatech Co.,Ltd 400-711-5280 86-571-81025280 sales@molcore.com China 9957 58
Aikon International Limited 025-66061636 19370895928 qqyang@aikonchem.com China 15810 58
Supplier Advantage
Shanghai Sunway Pharmaceutical Technology Co., Ltd 57
SynAsst Chemical. 55
Shanghai Raise Chemical Technology Co.,Ltd 55
Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd. 55
Cool Pharm, Ltd 58
Zhengzhou Alfachem Co., Ltd. 55
Amadis Chemical Company Limited 58
Shanghai CR Corporation Limited 58
Hangzhou Molcore Biopharmatech Co.,Ltd 58
Aikon International Limited 58

4-Bromomethyl-2-chloro-1-methoxybenzene Spectrum

4-BROMOMETHYL-2-CHLORO-1-METHOXYBENZENE(320407-92-9)1HNMR

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3-Chloro-4-Methoxybenzyl broMide -2-chloro-1-methoxybenzene Benzene, 4-(bromomethyl)-2-chloro-1-methoxy- RSYY（Avanafil)-58 4-bromethyl-2-chloro-1-methoxybenzene 4-Bromomethyl-2-chloro-1-methoxybenzene 320407-92-9 C8H8OClBr pharmacetical