4,6-Dimethylpyrimidine-5-carboxylic acid
- CAS No.
- 157335-93-8
- Chemical Name:
- 4,6-Dimethylpyrimidine-5-carboxylic acid
- Synonyms
- 5-Carboxy-4,6-dimethylpyrimidine;4,6-Dimethylpyrimidine-5-carboxylicaci;4,6-DIMETHYLPYRIMIDINE-5-CARBOXYLIC ACID;4,6-dimethyl 5-pyrimidine carboxylic acid;5-PyriMidinecarboxylicacid, 4,6-diMethyl-;4,6-DIMETHYLPYRIMIDINE-5-CARBOXYLIC ACID ,98%;5-Pyrimidinecarboxylicacid,4,6-dimethyl-(9CI);4,6-dimethylpyrimidine-5-carboxylic acid - [D20471];4,6-Dimethylpyrimidine-5-carboxylic acid ISO 9001：2015 REACH;5-Carboxy-4,6-dimethylpyrimidine, 5-Carboxy-4,6-dimethyl-1,3-diazine
- CBNumber:
- CB8691352
- Molecular Formula:
- C7H8N2O2
- Molecular Weight:
- 152.15
- MDL Number:
- MFCD07787545
- MOL File:
- 157335-93-8.mol
- MSDS File:
- SDS
| Boiling point | 319.7±37.0 °C(Predicted) |
|---|---|
| Density | 1.257±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| pka | 0.78±0.32(Predicted) |
| Appearance | White to off-white Solid |
| CAS DataBase Reference | 157335-93-8(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2933599590 |
4,6-Dimethylpyrimidine-5-carboxylic acid price More Price(63)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 271029 | 4,6-Dimethylpyrimidine-5-carboxylic acid Asreported | 157335-93-8 | 250mg | $322 | 2026-06-03 | Buy |
| Usbiological | 271029 | 4,6-Dimethylpyrimidine-5-carboxylic acid Asreported | 157335-93-8 | 500mg | $439 | 2026-06-03 | Buy |
| Usbiological | 271029 | 4,6-Dimethylpyrimidine-5-carboxylic acid Asreported | 157335-93-8 | 1g | $583 | 2026-06-03 | Buy |
| Usbiological | 271029 | 4,6-Dimethylpyrimidine-5-carboxylic acid Asreported | 157335-93-8 | 2g | $769 | 2026-06-03 | Buy |
| Usbiological | 271029 | 4,6-Dimethylpyrimidine-5-carboxylic acid Asreported | 157335-93-8 | 5g | $1027 | 2026-06-03 | Buy |
4,6-Dimethylpyrimidine-5-carboxylic acid Chemical Properties, Uses, Production
Uses
4,6-Dimethylpyrimidine-5-carboxylic acid is a pharmaceutical intermediate compound used in the preparation of macrocyclic broad-spectrum antibiotics.
Synthesis
305794-79-0
157335-93-8
Ethyl 4,6-dimethylpyrimidine-5-carboxylate (10.9 g, 0.0605 mol) was used as starting material, which was mixed with an aqueous solution (70 mL) of sodium hydroxide (4.0 g, 0.10 mol). The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the reaction solution was acidified with concentrated hydrochloric acid and subsequently the solution was concentrated to dryness. To the dried residue, acetone (100 mL) was added, the insoluble sodium chloride was removed by filtration, and the solid was washed with methanol (100 mL). The filtrate was concentrated to dryness and the resulting residue was washed with acetonitrile (ACN) to give a final 8.5 g (92% yield) of 4,6-dimethylpyrimidine-5-carboxylic acid solid product. The mass spectrum (EI) showed a m/z of 153.1 (M + 1). 1H NMR (400 MHz, CD3OD) data were as follows: δ 8.89 (s, 1H), 2.56 (s, 6H).
References
[1] Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 4, p. 709 - 712
[2] Patent: US2005/261310, 2005, A1. Location in patent: Page/Page column 1220
[3] Patent: US6391865, 2002, B1. Location in patent: Page column 86
[4] Patent: EP1175402, 2005, B1. Location in patent: Page/Page column 54
[5] Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 3, p. 567 - 571
4,6-Dimethylpyrimidine-5-carboxylic acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| PharmaBlock Sciences (Nanjing),Inc. | 025-86918202 4000255188 | sales@pharmablock.com | China | 5000 | 55 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Shanghai Sunway Pharmaceutical Technology Co., Ltd | 13761987713 | hxzheng@sunwaypharm.cn | China | 8663 | 57 |
| Shanghai Topbiochem Technology Co., Ltd | +86-21-60341587 | sales@topbiochem.com | China | 6166 | 58 |
| Nanjing Norris-Pharm Technology Co., Ltd | 13901585132 | sales@norris-pharm.com | China | 8869 | 55 |
View Latest Price from 4,6-Dimethylpyrimidine-5-carboxylic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | 4,6-Dimethylpyrimidine-5-carboxylic acid
157335-93-8
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2020-01-10 | 4,6-Dimethylpyrimidine-5-carboxylic acid
157335-93-8
|
$1.00 | 1KG | 98% | 200KG | Career Henan Chemical Co |
-
- 4,6-Dimethylpyrimidine-5-carboxylic acid
157335-93-8
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 4,6-Dimethylpyrimidine-5-carboxylic acid
157335-93-8
- $1.00
- 98%
- Career Henan Chemical Co
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