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5-IODOURIDINE

5-IODOURIDINE Structure
5-IODOURIDINE structure
CAS No.
1024-99-3
Chemical Name:
5-IODOURIDINE
Synonyms
8525;5-I-rU;5-I-Ur;5-Iodoruidine;5-IODOURIDINE;5-lodouridine;5-Iodo-D-uridine;Uridine, 5-iodo-;5-Iodouridine 95%;5-Iodouridine, >=99%
CBNumber:
CB8693129
Molecular Formula:
C9H11IN2O6
Molecular Weight:
370.1
MDL Number:
MFCD00006532
MOL File:
1024-99-3.mol
MSDS File:
SDS
Last updated:2026-01-13 11:26:27
Product description Number Pack Size Price
5-Iodouridine 95% 852597 1g $61.5
5-Iodouridine I1154 5G $120
5-Iodouridine 296188 500mg $347
5-Iodouridine 99+% 234247 250mg $184
5-Iodouridine I728940 5g $195
More product size
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5-IODOURIDINE Properties

Melting point 205-207 °C (dec.) (lit.)
Density 2.27±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility Acetonitrile: Slightly soluble
Methanol: Soluble
Water: Slightly soluble
pka 7.94±0.10(Predicted)
form Powder
color White
Water Solubility Soluble in water.
BRN 33665
InChI InChI=1S/C9H11IN2O6/c10-3-1-12(9(17)11-7(3)16)8-6(15)5(14)4(2-13)18-8/h1,4-6,8,13-15H,2H2,(H,11,16,17)/t4-,5-,6-,8-/m1/s1
InChIKey RKSLVDIXBGWPIS-UAKXSSHOSA-N
SMILES OC[C@H]1O[C@@H](N2C=C(I)C(=O)NC2=O)[C@H](O)[C@@H]1O
CAS DataBase Reference 1024-99-3(CAS DataBase Reference)
FDA UNII YZK4KVC76P
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P305+P351+P338
PPE Eyeshields, Gloves, type N95 (US)
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  22-24/25-36/37/39-27-26
WGK Germany  3
F  8-10
HS Code  29349990
Storage Class 11 - Combustible Solids

5-IODOURIDINE price More Price(39)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 852597 5-Iodouridine 95% 1024-99-3 1g $61.5 2025-07-31 Buy
TCI Chemical I1154 5-Iodouridine 1024-99-3 5G $120 2025-07-31 Buy
Usbiological 296188 5-Iodouridine 1024-99-3 500mg $347 2021-12-16 Buy
Usbiological 234247 5-Iodouridine 99+% 1024-99-3 250mg $184 2021-12-16 Buy
TRC I728940 5-Iodouridine 1024-99-3 5g $195 2021-12-16 Buy
Product number Packaging Price Buy
852597 1g $61.5 Buy
I1154 5G $120 Buy
296188 500mg $347 Buy
234247 250mg $184 Buy
I728940 5g $195 Buy

5-IODOURIDINE Chemical Properties,Uses,Production

Chemical Properties

White powder

Uses

5-Iodouridine has shown to enhance the effect of gamma irradiation in hamster cells. It is used as catalytic agent, petrochemical additive, used in organic synthesis.

Synthesis

Uridine

58-96-8

5-IODOURIDINE

1024-99-3

The general procedure for the synthesis of 5-iodouridine from 1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione was carried out as follows: in a round-bottomed flask, uracil (1 g, 4.1 mmol) and iodine (1.15 g, 4.5 mmol) were dissolved in a mixture of chloroform (55 ml) and 1M Nitric acid (10 ml) in a mixed solution. The reaction mixture was heated to 80°C and refluxed for 5 hours. The progress of the reaction was monitored by thin layer chromatography (TLC) and the unfolding agent was a chloroform solution of 30% methanol (Rf: 0.60; raw material Rf: 0.45). After completion of the reaction, the mixture was cooled to 4 °C and colorless needle-like 5-iodouridine crystals were precipitated. The precipitate was collected by filtration and dried under vacuum overnight to give 1.39 g of 5-iodouridine in 92% yield. The product was subjected to nuclear magnetic resonance hydrogen (1H NMR, DMSO-d6, 300 MHz) and carbon (13C NMR, DMSO-d6, 300 MHz) spectra to confirm the structure, and mass spectrometry (ESI) showed that the molecular ion peak [M+NH4]+ was 388.0000, which was consistent with the theoretical value.

Purification Methods

Recrystallise 5iodouridine from H2O and dry it in vacuo at 100o. UV has max 289nm (0.01N HCl) and 278nm (0.01N NaOH). [Prusoff et al. Cancer Res 13 221 1953, Beilstein 24 III/IV 1235.]

References

[1] Bulletin of the Korean Chemical Society, 2018, vol. 39, # 9, p. 1054 - 1057
[2] Synthetic Communications, 1990, vol. 20, # 21, p. 3391 - 3394
[3] Canadian Journal of Chemistry, 1994, vol. 72, # 9, p. 2005 - 2010
[4] Patent: WO2011/51733, 2011, A2. Location in patent: Page/Page column 44
[5] Synthesis, 2009, # 23, p. 3957 - 3962
[6] EDWARD BRESNICK  Karen B. Inhibition of dihydroorotase by purines and pyrimidines[J]. Biochimica et Biophysica Acta (BBA) - Specialized Section on Enzymological Subjects, 1964, 81 1: Pages 150-157. DOI: 10.1016/0926-6569(64)90345-1
[7] Y KURODA  T K  A Yokoiyama. Radiosensitization of cultured mammalian cells by 5-iodouridine.[J]. International journal of radiation biology and related studies in physics, chemistry, and medicine, 1975, 27 3: 247-257. DOI: 10.1080/09553007514551541
[8] RAKESH KUMAR. Synthesis and antiviral and cytotoxic activity of iodohydrin and iodomethoxy derivatives of 5-vinyl-2’-deoxyuridines, 2’-fluoro-2’-deoxyuridine, and uridine[J]. Journal of Medicinal Chemistry, 1990, 33 2: 717-723. DOI: 10.1021/jm00164a039

5-IODOURIDINE Preparation Products And Raw materials

Raw materials

5-Iodo-2',3',5'-tri-O-acetyluridine Uridine iodine Nitric acid Chloroform

Preparation Products

5-IODOURIDINE Suppliers

Global( 216)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29832 58
Zhejiang ZETian Fine Chemicals Co. LTD 		+8618957127338 stella@zetchem.com China 2994 58
Nanjing Baifuli Technology Co., Ltd. 		+86-15335185688 sales@unisyn.cn CHINA 332 58
Hubei xin bonus chemical co. LTD 		86-13657291602 linda@hubeijusheng.com CHINA 22963 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19552 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
TopScience Biochemical 		00852-68527855 info@itopbiochem.com China Hong Kong 902 58
Antai Fine Chemical Technology Co.,Limited 		18503026267 info@antaichem.com CHINA 9636 58
SHANGHAI T&W PHARMACEUTICAL CO., LTD. 		+86-021-61551413 +8618813727289 contact@trustwe.com China 5742 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Zhejiang ZETian Fine Chemicals Co. LTD 		58
Nanjing Baifuli Technology Co., Ltd. 		58
Hubei xin bonus chemical co. LTD 		58
BOC Sciences 		58
Alchem Pharmtech,Inc. 		58
TopScience Biochemical 		58
Antai Fine Chemical Technology Co.,Limited 		58
SHANGHAI T&W PHARMACEUTICAL CO., LTD. 		58

View Lastest Price from 5-IODOURIDINE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
5-Iodouridine pictures 2026-02-03 5-Iodouridine
1024-99-3
 US $0.00-0.00 / KG 10g 99%min 100kgs WUHAN FORTUNA CHEMICAL CO., LTD
5-IODOURIDINE pictures 2025-09-23 5-IODOURIDINE
1024-99-3
 US $0.00-0.00 / G 1G 98% 2000 Shenzhen Nexcon Pharmatechs Ltd.
5-Iodouridine pictures 2025-04-28 5-Iodouridine
1024-99-3
 US $0.00 / mg 10g TargetMol Chemicals Inc.
  • 5-Iodouridine pictures
  • 5-Iodouridine
    1024-99-3
  • US $0.00-0.00 / KG
  • 99%min
  • WUHAN FORTUNA CHEMICAL CO., LTD
  • 5-IODOURIDINE pictures
  • 5-IODOURIDINE
    1024-99-3
  • US $0.00-0.00 / G
  • 98%
  • Shenzhen Nexcon Pharmatechs Ltd.

5-IODOURIDINE Spectrum

5-IODOURIDINE(1024-99-3)1HNMR5-IODOURIDINE(1024-99-3)Raman5-IODOURIDINE(1024-99-3)FT-IR5-IODOURIDINE(1024-99-3)IR

1024-99-3(5-IODOURIDINE)Related Search:

5-IODOURIDINE Idoxuridine Uridine 2'-deoxy-5-iodouridine 3',5'-diacetate 2'-Deoxy-5-iodouridine 5'-(4-nitrobenzoate)
2'-(O-METHYL)-5-IODOURIDINE 5'-O-(DIMETHOXYTRITYL)-5-IODO-2'-O-METHYLURIDINE 5'-deoxy-5'-iodouridine 2',3'-DIDEOXY-5-IODOURIDINE 3'-fluoro-2',3'-dideoxy-5-iodouridine,2',3'-Dideoxy-3'-fluoro-5-iodouridine
5-IODOURIDINE 5-MONOPHOSPHATE SODIUM,5-IODOURIDINE 5'-MONOPHOSPHATE SODIUM SALT 5-Iodouridine 3',5'-phosphoric acid 5-IODOURIDINE, HPLC PURIFIED, 98% PURE WITH HPLC UV CHROMATOGRAM 5'-Amino-2',5'-dideoxy-5-iodouridine ANTI-5-IODOURIDINE,ANTI-IODOURIDINE
5'-amido-2',5'-dideoxy-5-iodouridine 5-iodouridine 5'-triphosphate sodium 2'-O,3'-O,5'-O-Triacetyl-5-iodouridine,5-Iodouridine 2',3',5'-triacetate

1of4

5-IODOURIDINE 5-IODO-1-(BETA-D-RIBOFURANOSYL)URACIL 2,4-DIHYDROXY-5-IODO-1-BETA-D-RIBOFURANOSYLPYRIMIDINE 2,4-dihydroxy-5-iodo-1-β-d-ribofuranosylpyrimidine 5-Iodo-D-uridine 1-(β-D-Ribofuranosyl)-2-hydroxy-5-iodopyrimidine-4(1H)-one 1-β-D-Ribofuranosyl-2-hydroxy-5-iodo-1,4-dihydropyrimidine-4-one 5-Iodoruidine 1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxyMethyl)tetrahydrofuran-2-yl)-5-iodopyriMidine-2,4(1H,3H)-dione 5-Iodouridine 95% 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-tetrahydrofuranyl]-5-iodopyrimidine-2,4-dione 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-iodo-pyrimidine-2,4-dione 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-iodopyrimidine-2,4-dione 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-iodo-pyrimidine-2,4-dione 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methylol-tetrahydrofuran-2-yl]-5-iodo-pyrimidine-2,4-quinone 1-[3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-iodopyrimidine-2,4(1H,3H)-dione 8525 Uridine, 5-iodo- (8CI)(9CI) 5-Iodouridine, >=99% 5-I-rU Uridine, 5-iodo- 5-I-Ur 5-IODOURIDINE USP/EP/BP 5-lodo-Uridine(5-I-Ur) 5-lodouridine 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-iodo-1,2,3,4-tetrahydropyrimidine-2,4-dione 1024-99-3 C9H11IN2O6 Nucleosides, Nucleotides, Oligonucleotides Nucleoside Analogs Pyrimidines Halogenated Heterocycles Heterocyclic Building Blocks BioChemical Building Blocks Biochemicals and Reagents Nucleosides-5-I Nucleosides