1-Naphthyl isothiocyanate
- CAS No.
- 551-06-4
- Chemical Name:
- 1-Naphthyl isothiocyanate
- Synonyms
- ANI;ANIT;Kesscocide;1-Naphthyl senfoel;Naphthyl mustard oil;1-Naftylisothiokyanat;Naphthyl isothiocyanat;1-NAPTHYL ISOTHIOCYANATE;1-Naphtyl isothiocyanate;1-NAPHTHYL ISOTHIOCYANATE
- CBNumber:
- CB8696418
- Molecular Formula:
- C11H7NS
- Molecular Weight:
- 185.24
- MDL Number:
- MFCD00003882
- MOL File:
- 551-06-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 55.5-57 °C(lit.) |
|---|---|
| Boiling point | 190 °C(Press: 20 Torr) |
| Density | 1.1142 (rough estimate) |
| refractive index | 1.5500 (estimate) |
| storage temp. | 2-8°C |
| form | Fine Crystalline Powder |
| color | Yellow |
| Water Solubility | insoluble |
| Sensitive | Moisture Sensitive |
| Merck | 14,6411 |
| BRN | 637868 |
| Stability | Stable, but moisture sensitive. Incompatible with strong oxidizing agents. |
| InChI | 1S/C11H7NS/c13-8-12-11-7-3-5-9-4-1-2-6-10(9)11/h1-7H |
| InChIKey | JBDOSUUXMYMWQH-UHFFFAOYSA-N |
| SMILES | S=C=Nc1cccc2ccccc12 |
| CAS DataBase Reference | 551-06-4(CAS DataBase Reference) |
| FDA UNII | HG44814A3V |
| NIST Chemistry Reference | Naphthalene, 1-isothiocyanato-(551-06-4) |
| EPA Substance Registry System | 1-Naphthylisothiocyanate (551-06-4) |
| UNSPSC Code | 41116105 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS08 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H332-H315-H319-H334-H335 | |||||||||
| Precautionary statements | P501-P261-P270-P271-P264-P280-P284-P302+P352-P342+P311-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P310+P330-P304+P340+P312-P403+P233-P405 | |||||||||
| target organs | Respiratory system | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 20/21-25-36/37/38-42-23/24/25 | |||||||||
| Safety Statements | 22-26-36/37-45-24/25 | |||||||||
| RIDADR | UN 2811 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | NX9100000 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29309090 | |||||||||
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
|||||||||
| Hazard Classifications | Acute Tox. 3 Oral Eye Irrit. 2 Resp. Sens. 1 Skin Irrit. 2 STOT SE 3 |
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| Limited Quantities | 5.0 kg (11 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
1-Naphthyl isothiocyanate price More Price(30)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | N4525 | 1-Naphthyl isothiocyanate 95% | 551-06-4 | 10g | $134 | 2026-04-30 | Buy |
| Sigma-Aldrich | 18951 | 1-Naphthyl isothiocyanate for HPLC derivatization, ≥98.5% (HPLC and GC) | 551-06-4 | 1g | $51.2 | 2022-05-15 | Buy |
| TCI Chemical | I0190 | 1-Naphthyl Isothiocyanate >98.0%(GC) | 551-06-4 | 5g | $94 | 2026-04-30 | Buy |
| TCI Chemical | I0190 | 1-Naphthyl Isothiocyanate >98.0%(GC) | 551-06-4 | 25g | $295 | 2026-04-30 | Buy |
| Usbiological | 284997 | 1-Naphthyl isothiocyanate Asreported | 551-06-4 | 25g | $789 | 2026-06-03 | Buy |
1-Naphthyl isothiocyanate Chemical Properties, Uses, Production
Description
1-Napthylisothiocyanate is a toxic chemical that has been used to create experimental cholestasis in rodents. Laboratory studies have also shown that 1-napthylisothiocyanate can act as a chemoprotectant in rodents challenged with a tumorinducing agent such as phorbol-12 myristate 13-acetate.
Chemical Properties
white crystalline powder
Uses
1-Naphthylisothiocyanate is used as an ingredient in insecticides. It is also found in cyanamide, which is used in many industrial applications. It is commonly used in medical and drug studies in animals as a model hepatotoxicant producing experimental cholestasis in rats and mice.
Uses
1-Naphthyl isothiocyanate is a tool for the study of liver damage which causes bile stasis and hyperbilirubinemia acutely and bile duct hyperplasia and biliary cirrhosis chronically, with changes in hepatocyte function.
Uses
1-Naphthyl isothiocyanate (NITC) can be used as a source of thiourea moiety to synthesize derivatives of calix[4]arenes to be used as anion acceptors. It can also be used for the synthesis of naphthyl substituted 1,2,4-triazoles and 1,3,4-thiadiazoles.
Definition
ChEBI: 1-naphthyl isothiocyanate is an isothiocyanate. It has a role as an insecticide. It derives from a hydride of a naphthalene.
General Description
Odorless white needles or powder. Tasteless.
Air & Water Reactions
1-Naphthyl isothiocyanate is moisture sensitive. . Undergoes slow hydrolysis. Insoluble in water.
Reactivity Profile
Isocyanates and thioisocyanates, such as 1-Naphthyl isothiocyanate, are incompatible with many classes of compounds, reacting exothermically to release toxic gases. Reactions with amines, aldehydes, alcohols, alkali metals, ketones, mercaptans, strong oxidizers, hydrides, phenols, and peroxides can cause vigorous releases of heat. Acids and bases initiate polymerization reactions in these materials. Some isocyanates react with water to form amines and liberate carbon dioxide. Base-catalysed reactions of isocyanates with alcohols should be carried out in inert solvents. Such reactions in the absence of solvents often occur with explosive violence, [Wischmeyer(1969)].
Fire Hazard
Flash point data for 1-Naphthyl isothiocyanate is not available, but 1-Naphthyl isothiocyanate is probably combustible.
Environmental Fate
Naphthylisothiocyanate is moisture sensitive and insoluble in water. The hydrolysis rate is slow.
Purification Methods
Crystallise the isothiocyanate from hexane (1g in 9 mL). It forms white needles and is soluble in most organic solvents but is insoluble in H2O. It is absorbed through the skin and may cause dermatitis. [Cymmerman-Craig et al. Org Synth Coll Vol IV 700 1963, Beilstein 12 H 1244, 12 III 2948.]
Toxicity evaluation
1-Naphthylisothiocyanate causes separation of extracellular tight junctions that seal bile canaliculi, impairing bile formation. 1-Naphthylisothiocyanate inhibits microsomal drug-metabolizing activity. In rats, 1-naphthylisothiocyanteglutathione complex is formed in hepatocytes, then transported to the bile ducts, where it is released from the glutathione, and then selectively injures biliary epithelial cells, resulting in reduced bile flow.
1-Naphthyl isothiocyanate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Syntechem Co.,Ltd | info@syntechem.com | China | 12973 | 57 | |
| Tianjin heowns Biochemical Technology Co., Ltd. | 400 638 7771 | sales@heowns.com | China | 14412 | 57 |
| Beijing Taiya Jie Technology Development Co., Ltd. | 021-33690831-8001 13552411790;18616022633 | postmaster@tyjchem.cn | China | 1541 | 55 |
View Latest Price from 1-Naphthyl isothiocyanate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-02 | 1-Naphthyl isothiocyanate
551-06-4
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2019-12-23 | 1-Naphthyl isothiocyanate
551-06-4
|
$1.00 | 1g | 85.0-99.8% | 20ton | Career Henan Chemical Co |
-
- 1-Naphthyl isothiocyanate
551-06-4
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 1-Naphthyl isothiocyanate
551-06-4
- $1.00
- 85.0-99.8%
- Career Henan Chemical Co
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