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8-Nitroquinoline

8-Nitroquinoline Structure
8-Nitroquinoline structure
CAS No.
607-35-2
Chemical Name:
8-Nitroquinoline
Synonyms
NSC 346;AKOS 214-03;8-NitroquinoL;8-Nitrochinolin;8-nitro-quinolin;8-Nitroqunioline;8-NITROQUINOLINE;Quinoline,8-nitro-;Quinoline, 8-nitro-;8-Nitroquinoline>
CBNumber:
CB8719823
Molecular Formula:
C9H6N2O2
Molecular Weight:
174.16
MDL Number:
MFCD00006806
MOL File:
607-35-2.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 05:16:32
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8-Nitroquinoline Properties

Melting point 89-91 °C (lit.)
Boiling point 305.12°C (rough estimate)
Density 1.2190 (estimate)
refractive index 1.6820 (rough estimate)
storage temp. Sealed in dry,Room Temperature
form powder to crystal
pka 1.20±0.17(Predicted)
color Monoclinic crystals from alcohol
Water Solubility Soluble in ethanol, ethyl ether and benzene, slightly soluble in cold water.
BRN 135178
InChI InChI=1S/C9H6N2O2/c12-11(13)8-5-1-3-7-4-2-6-10-9(7)8/h1-6H
InChIKey OQHHSGRZCKGLCY-UHFFFAOYSA-N
SMILES N1C2C(=CC=CC=2[N+]([O-])=O)C=CC=1
CAS DataBase Reference 607-35-2(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII YWO6S88V4V
NIST Chemistry Reference 8-Nitro quinoline(607-35-2)
EPA Substance Registry System Quinoline, 8-nitro- (607-35-2)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)Health Hazard (GHS08)
GHS07,GHS08
Signal word  Warning
Hazard statements  H302+H312+H332-H315-H319-H335-H351
Precautionary statements  P280-P301+P312-P302+P352+P312-P304+P340+P312-P305+P351+P338-P308+P313
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xn,Xi
Risk Statements  20/21/22-36/37/38-40-68
Safety Statements  26-27-36/37/39-36
WGK Germany  3
RTECS  VC1925000
Hazard Note  Harmful/Irritant
TSCA  TSCA listed
HS Code  29334900
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Acute Tox. 4 Oral
Carc. 2
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
Hazardous Substances Data 607-35-2(Hazardous Substances Data)
Toxicity TD orl-rat: 36,400 mg/kg/2Y-C:CAR,REP CALEDQ14,115,81
NFPA 704
1
2 0

8-Nitroquinoline price More Price(60)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 130273 8-Nitroquinoline 98% 607-35-2 5g $54.5 2026-04-30 Buy
TCI Chemical N0345 8-Nitroquinoline >99.0%(GC)(T) 607-35-2 5g $47 2026-04-30 Buy
TCI Chemical N0345 8-Nitroquinoline >99.0%(GC)(T) 607-35-2 25g $136 2026-04-30 Buy
Usbiological 285032 8-Nitroquinoline Asreported 607-35-3 5g $307 2026-06-03 Buy
Usbiological 285032 8-Nitroquinoline Asreported 607-35-3 10g $413 2026-06-03 Buy
Product number Packaging Price Buy
130273 5g $54.5 Buy
N0345 5g $47 Buy
N0345 25g $136 Buy
285032 5g $307 Buy
285032 10g $413 Buy

8-Nitroquinoline Chemical Properties, Uses, Production

Chemical Properties

white to light yellow crystal powder

Uses

8-Nitroquinoline was used to prepare furazano [3,4-h] quinoline. It was also used to synthesize corresponding 2-substituted phenoxy-6-methoxy-8-aminoquinoline.

Safety Profile

Poison by intraperitoneal route. Experimental reproductive effects. Questionable carcinogen with experimental carcinogenic data. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

Synthesis

Quinoline

91-22-5

8-Nitroquinoline

607-35-2

5-Nitroquinoline

607-34-1

General procedure for the synthesis of 8-nitroquinoline and 5-nitroquinoline from quinoline: Pure sulfuric acid (H2SO4) was slowly added to 1 equivalent of quinoline at 0 °C. Subsequently, 3 equivalents of 65% nitric acid (HNO3) were added dropwise and the reaction mixture was stirred at room temperature for 1 hour. Upon completion of the reaction, the mixture was poured sequentially into water, neutralized with sodium carbonate (Na2CO3) and then extracted twice with dichloromethane. The organic layer was washed with water and dried with anhydrous sodium sulfate (Na2SO4) followed by evaporation of the solvent under vacuum. 8-Nitroquinoline (compound 35) was obtained as a light yellow solid in 34% yield; melting point 90 °C, literature value: 89-90 °C [43].1H NMR (200 MHz, CDCl3) δ: 7.53-7.66 (m, 2H), 8.04 (d, J=8.0 Hz, 2H), 8.27 (dd, J=1.6 and 8.4 Hz, 1H). 9.70 (dd, J=1.7 and 4.2 Hz, 1H). 13C NMR (50 MHz, CDCl3) δ: 122.8 (CH), 123.8 (CH), 125.3 (CH), 129.0 (C), 132.0 (CH), 136.1 (CH), 139.5 (C), 148.2 (C), 152.6 (CH ). Recrystallization by isopropanol afforded 5-nitroquinoline (compound 36) as a light yellow solid in 38% yield; melting point 71 °C, literature value: 71-72 °C [41].1H NMR (200 MHz, CDCl3) δ: 7.61-7.68 (m, 1H), 7.76-7.85 (m, 1H), 8.36-8.45 (m, 2H). 8.98-9.04 (m, 2H).13C NMR (50MHz, CDCl3) δ: 121.2 (C), 123.9 (CH), 124.6 (CH), 127.5 (CH), 131.9 (CH), 136.6 (CH), 145.5 (C), 148.2 (C), 151.6 (C).

References

[1] European Journal of Medicinal Chemistry, 2012, vol. 54, p. 75 - 86
[2] European Journal of Medicinal Chemistry, 2018, vol. 155, p. 135 - 152
[3] Journal of the Chemical Society, 1892, vol. 61, p. 788
[4] Chemische Berichte, 1885, vol. 18, p. 1243
[5] Journal fuer Praktische Chemie (Leipzig), 1896, vol. <2> 53, p. 392

8-Nitroquinoline Preparation Products And Raw materials

Raw materials

2-Nitroaniline Arsenic pentoxide Acrolein diethyl acetal Quinoline Glycerol
Sodium 3-nitrobenzenesulphonate Sodium carbonate

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Preparation Products

7-Chloro-8-aminoquinoline 5-Chloroquinolin-8-amine 2,3-Dinitrobenzoic acid

8-Nitroquinoline Suppliers

Global Suppliers ( 303)
Supplier Tel Email Country ProdList Advantage
CHANGZHOU MALONG CHEMICALS CO., LTD. 18651958646 info@malongchem.com China 185 58
Shandong Yizhi Medical Technology Co., LTD 13287715206 15508629772 2786175817@qq.com China 65 58
Nanbu County Chengxin Technology Co., Ltd. 0838-5675166 15883665058 nbcxkj@126.com China 956 55
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
INTATRADE GmbH +49 3493/605464 sales@intatrade.de Germany 3563 66
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
ShangHai DEMO Chemical Co.,Ltd 400-021-7337 2355568890 sales@demochem.com China 2569 57
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Supplier Advantage
CHANGZHOU MALONG CHEMICALS CO., LTD. 58
Shandong Yizhi Medical Technology Co., LTD 58
Nanbu County Chengxin Technology Co., Ltd. 55
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
INTATRADE GmbH 66
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
ShangHai DEMO Chemical Co.,Ltd 57
Energy Chemical 61

View Latest Price from 8-Nitroquinoline manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
8-Nitroquinoline pictures 2026-09-02 8-Nitroquinoline
607-35-2
 $8.00 1KG 99% Henan Fengda Chemical Co., Ltd
8-Nitroquinoline pictures 2026-08-20 8-Nitroquinoline
607-35-2
 $1.10 1g 99.00% 100 Tons Dideu Industries Group Limited
8-Nitroquinoline pictures 2025-04-04 8-Nitroquinoline
607-35-2
 1KG 98% 1Ton Henan Aochuang Chemical Co.,Ltd.

8-Nitroquinoline Spectrum

8-Nitroquinoline(607-35-2)MS8-Nitroquinoline(607-35-2)1HNMR8-Nitroquinoline(607-35-2)13CNMR8-Nitroquinoline(607-35-2)IR18-Nitroquinoline(607-35-2)IR28-Nitroquinoline(607-35-2)Raman

607-35-2 (8-Nitroquinoline) Related Search:

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2-Methyl-8-nitroquinoline 2-Chloro-6-nitroquinoline 7-Methyl-8-nitroquinoline 4-Hydroxy-6-nitroquinoline 6-Methoxy-8-nitroquinoline
5-Bromo-8-nitroquinoline 2-Nitroquinoline 5-NITROQUINOLINE 98+%

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