IACS-9571 trifluoroacetate salt
- CAS No.
- 1883598-69-3
- Chemical Name:
- IACS-9571 trifluoroacetate salt
- Synonyms
- IACS-9571 TFA;IACS-9571 trifluoroacetate salt
- CBNumber:
- CB87246063
- Molecular Formula:
- C34H43F3N4O10S
- Molecular Weight:
- 756.79
- MDL Number:
- MOL File:
- 1883598-69-3.mol
- MSDS File:
- SDS
| storage temp. | 2-8°C |
|---|---|
| solubility | DMSO: 2mg/mL, clear |
| form | powder |
| color | white to beige |
| InChIKey | GAOCLDPTFLDJIP-UHFFFAOYSA-N |
| SMILES | O=S(C1=CC=C(C(OC)=C1)OC)(NC2=C(C=C(C3=C2)N(C(N3C)=O)C)OC4=CC(OCCC)=CC(OCCCCN(C)C)=C4)=O.FC(F)(C(O)=O)F |
| UNSPSC Code | 12352200 |
| NACRES | NA.21 |
IACS-9571 trifluoroacetate salt price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML2335 | IACS-9571 trifluoroacetate salt ≥98% (HPLC) | 1883598-69-3 | 5MG | $108 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML2335 | IACS-9571 trifluoroacetate salt ≥98% (HPLC) | 1883598-69-3 | 25MG | $370.6 | 2026-04-30 | Buy |
| Aaron Chemicals | AR01E46U | IACS-9571 Trifluoroacetate | 1883598-69-3 | 5mg | $210 | 2026-06-03 | Buy |
| TRC | I942035 | IACS-9571Trifluoroacetate | 1883598-69-3 | 25mg | $3850 | 2021-12-16 | Buy |
IACS-9571 trifluoroacetate salt Chemical Properties, Uses, Production
Uses
A bromodomain Inhibitor. This domain contains proteins that are involved in the epigenetic regulation of gene expression and have been implicated in human cancer.
Biological Activity
IACS-9571 is a dimethylamine analogue.', 'IACS-9571 is a high-affinity, potent TRIM24/BRPF1 bromodomain (BrD) inhibitor (Kd = 1.3/2.1 nM by DiscoveRx) with good selectivity over other BrDs (BRPF2/3 Kd = 12/27 nM, BAZ2B/TAF1 BrD2/BRD4 BrD1,2 Kd = 0.4/1.8/>10 μM by DiscoveRx; ≤63% binding inhibition of 25 other BrDs at 1 μM). IACS-9571 potently blocks H3K23Ac peptide from TRIM24 BrD binding (IC50 = 7.6 nM) and displaces ectopically expressed TRIM24 PHD-BrD from endogenous histone H3 in 2-hr 5 μM SAHA-stimulated HeLa cells (IC50 = 50 nM). When adiministered in mice, IACS-9571 exhibits good pharmacokinetics and oral availability in vivo (F = 29%, 10 mg/kg p.o.).
IACS-9571 trifluoroacetate salt Preparation Products And Raw materials
Raw materials
Preparation Products
IACS-9571 trifluoroacetate salt Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
