Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN

7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN

7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN Structure
7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN structure
CAS No.
62252-26-0
Chemical Name:
7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN
Synonyms
JLK6;JCP 251);JCP251 (JCP-251;JLK6, 10 mM in DMSO;GAMMA-SECRETASE INHIBITOR XI;7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN;7-Amino-4-chloro-3-methoxy-1H-2-benzopyran;7-Amino-4-chloro-3-methoxy-isochromen-1-one;7-Amino-4-chloro-3-methoxy-1H-isochromen-1-one;1H-2-Benzopyran-1-one, 7-amino-4-chloro-3-methoxy-
CBNumber:
CB8741619
Molecular Formula:
C10H8ClNO3
Molecular Weight:
225.63
MDL Number:
MFCD04035584
MOL File:
62252-26-0.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 05:24:56
Product description Number Pack Size Price
JCP251 ≥95% 28712 5mg $87
JCP251 ≥95% 28712 10mg $165
JCP251 ≥95% 28712 50mg $653
JCP251 ≥95% 28712 100mg $1043
JLK 6 Asreported 255556 10mg $458
Request For Quotation

7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN Properties

Melting point 115 °C
Boiling point 456.1±45.0 °C(Predicted)
Density 1.46±0.1 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,2-8°C
solubility DMSO (Slightly)
pka 1.95±0.20(Predicted)
form Solid
color Yellow to Beige
Stability Hygroscopic

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362

7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN price More Price(37)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 28712 JCP251 ≥95% 62252-26-0 5mg $87 2026-04-30 Buy
Cayman Chemical 28712 JCP251 ≥95% 62252-26-0 10mg $165 2026-04-30 Buy
Cayman Chemical 28712 JCP251 ≥95% 62252-26-0 50mg $653 2026-04-30 Buy
Cayman Chemical 28712 JCP251 ≥95% 62252-26-0 100mg $1043 2026-04-30 Buy
Usbiological 255556 JLK 6 Asreported 62252-26-0 10mg $458 2026-06-03 Buy
Product number Packaging Price Buy
28712 5mg $87 Buy
28712 10mg $165 Buy
28712 50mg $653 Buy
28712 100mg $1043 Buy
255556 10mg $458 Buy

7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN Chemical Properties,Uses,Production

Uses

JLK 6 is an inhibitor of γ-secretase, selectively inhibits βAPP cleavage.

Definition

ChEBI: 7-amino-4-chloro-3-methoxy-2-benzopyran-1-one is a member of isocoumarins.

Biological Activity

Inhibitor of γ -secretase that selectively inhibits β APP cleavage without affecting other γ -secretase-mediated pathways. Prevents recovery of A β 40 and A β 42 from HEK293 cell overexpressing wild-type or Swedish-mutated β APP (IC 50 ~ 30 μ M) but displays no effect on Notch cleavage and Notch-mediated intracellular signaling. Displays no activity on BACE1, BACE2, α -secretase, the proteosome or GSK3 β .

References

[1]. petit a, pasini a, alves da costa c, et al. jlk isocoumarin inhibitors: selective γ-secretase inhibitors that do not interfere with notch pathway in vitro or in vivo. journal of neuroscience research, 2003, 74(3): 370-377.
[2]. petit a, bihel f, da costa ca, et al. new protease inhibitors prevent γ-secretase-mediated production of aβ40/42 without affecting notch cleavage. nature cell biology, 2001, 3(5): 507-511.

7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN Preparation Products And Raw materials

Raw materials

Preparation Products

7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN Suppliers

Global( 71)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
Career Henan Chemica Co 		+86-0371-86658258 +86-13203830695 laboratory@coreychem.com China 30203 58
Wuhan Topule Biopharmaceutical Co., Ltd 		+86-18327326525 masar@topule.com China 8433 58
Jilin Chinese Academy of Sciences-yanshen Technology 		18143011203 info@chemextension.com China 42052 58
Aladdin Scientific 		tp@aladdinsci.com United States 50108 58
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 9920 65
Shanghai Raise Chemical Technology Co.,Ltd 15026594951 rs@raise-chem.com China 4836 55
AdooQ BioScience, LLC +1 (866) 930-6790 info@adooq.com United States 2774 58
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4859 55
Supplier Advantage
TargetMol Chemicals Inc. 		58
Career Henan Chemica Co 		58
Wuhan Topule Biopharmaceutical Co., Ltd 		58
Jilin Chinese Academy of Sciences-yanshen Technology 		58
Aladdin Scientific 		58
3B Pharmachem (Wuhan) International Co.,Ltd. 69
BOC Sciences 65
Shanghai Raise Chemical Technology Co.,Ltd 55
AdooQ BioScience, LLC 58
Shanghai Lollane Biological Technology Co.,Ltd. 55

View Lastest Price from 7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
JLK6 pictures 2026-05-23 JLK6
62252-26-0
 $80.00-235.00 96.50% 10g TargetMol Chemicals Inc.
  • JLK6 pictures
  • JLK6
    62252-26-0
  • $80.00-235.00
  • 96.50%
  • TargetMol Chemicals Inc.

7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN Spectrum

7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN(62252-26-0)1HNMR

62252-26-0(7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN)Related Search:

GAMMA-SECRETASE INHIBITOR 2-(Chloromethyl)benzoic acid 7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN Methyl 2-chloromethylbenzoate 1H-2-Benzopyran-1-one
3-METHOXY-1H-ISOCHROMEN-1-ONE BENZOIC ACID, 5-AMINO-2-METHYL-, METHYL ESTER, HYDROCHLORIDE 1,1-DIMETHOXYETHENE

1of2

JCP 251) JCP251 (JCP-251 JLK6 GAMMA-SECRETASE INHIBITOR XI 7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN 7-Amino-4-chloro-3-methoxy-1H-2-benzopyran 7-Amino-4-chloro-3-methoxy-isochromen-1-one 7-Amino-4-chloro-3-methoxy-1H-isochromen-1-one 1H-2-Benzopyran-1-one, 7-amino-4-chloro-3-methoxy- JLK 6,Amyloid-β,β-amyloid peptide,JLK-6,Abeta,Inhibitor,JLK6,inhibit,APP,amyloid β JLK6, 10 mM in DMSO 62252-26-0