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12-Crown-4

12-Crown-4 structure

CAS No.: 294-93-9

Chemical Name:: 12-Crown-4

Synonyms: Crown;1,4,7,10-TETRAOXACYCLODODECANE;12-CROWN 4-ETHER;12-C-4;Eoct;12C4;12 C 4;12-CROWN-4;12-Crown-4,97%;LITHIUM IONOPHORE V

CBNumber:: CB8752442

Molecular Formula:: C8H16O4

Molecular Weight:: 176.21

MDL Number:: MFCD00005103

MOL File:: 294-93-9.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 05:28:46

Product description	Number	Pack Size	Price
12-Crown-4 98%	194905	1g	$68.6
12-Crown-4 98%	194905	5g	$163
12-Crown 4-Ether >95.0%(GC)	C0858	1mL	$54
12-Crown 4-Ether >95.0%(GC)	C0858	5mL	$177
12-Crown-4	TRC-C790010-50MG	50mg	$65
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12-Crown-4 Properties

Melting point	16 °C (lit.)
Boiling point	61-70 °C/0.5 mmHg (lit.)
Density	1.089 g/mL at 25 °C (lit.)
refractive index	n20/D 1.463(lit.)
Flash point	>230 °F
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
form	Liquid After Melting
Specific Gravity	1.115 (20℃)
color	Clear colorless to slightly yellow
Water Solubility	MISCIBLE
Sensitive	Air Sensitive
BRN	1363064
InChI	1S/C8H16O4/c1-2-10-5-6-12-8-7-11-4-3-9-1/h1-8H2
InChIKey	XQQZRZQVBFHBHL-UHFFFAOYSA-N
SMILES	C1COCCOCCOCCO1
CAS DataBase Reference	294-93-9(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	K6069P2C2A
NIST Chemistry Reference	12-Crown-4(294-93-9)
EPA Substance Registry System	1,4,7,10-Tetraoxacyclododecane (294-93-9)
UNSPSC Code	12352005
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06

Signal word

Danger

Hazard statements

H330

Precautionary statements

P304+P340+P310

PPE

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Hazard Codes

T+,Xn,Xi

Risk Statements

26-36/37/38-20/21/22

Safety Statements

28-36/37-45-36-26

RIDADR

UN 2810

WGK Germany

RTECS

XF0550000

3-9-23

TSCA

TSCA listed

HazardClass

6.1

PackingGroup

III

HS Code

29329995

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials

Hazard Classifications

Acute Tox. 1 Inhalation

Toxicity

LD50 oral in rat: 2830mg/kg

NFPA 704

	1
4		1

12-Crown-4 price More Price(41)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	194905	12-Crown-4 98%	294-93-9	1g	$68.6	2026-04-30	Buy
Sigma-Aldrich	194905	12-Crown-4 98%	294-93-9	5g	$163	2026-04-30	Buy
TCI Chemical	C0858	12-Crown 4-Ether >95.0%(GC)	294-93-9	1mL	$54	2026-04-30	Buy
TCI Chemical	C0858	12-Crown 4-Ether >95.0%(GC)	294-93-9	5mL	$177	2026-04-30	Buy
TRC	TRC-C790010-50MG	12-Crown-4	294-93-9	50mg	$65	2026-06-03	Buy

Product number	Packaging	Price	Buy
194905	1g	$68.6	Buy
194905	5g	$163	Buy
C0858	1mL	$54	Buy
C0858	5mL	$177	Buy
TRC-C790010-50MG	50mg	$65	Buy

12-Crown-4 Chemical Properties,Uses,Production

Chemical Properties

clear colorless to slightly yellow liquid after

Uses

It serves as an aprotic "solvent" for alkali metals, the sodium solution is a strong reducing agent.

Uses

12-Crown-4 can be used as:

A promoter in the synthesis of poly(diethylsiloxane) (PDES) from monomer hexaethylcyclotrisiloxane using NaOH as a catalyst via anionic ring-opening polymerization.
As an additive in the preparation of triarylmethane derivatives by palladium-catalyzed cross coupling reaction of aryl bromides with diarylmethane derivatives.
A phase transfer catalyst in organic synthesis.

Definition

ChEBI: A crown ether that is cyclododecane in which the carbon atoms at positions 1, 4, 7 and 10 have been replaced by oxygen atoms.

Synthesis Reference(s)

Tetrahedron Letters, 15, p. 4029, 1974 DOI: 10.1016/S0040-4039(01)92075-1

General Description

12-Crown-4 is a crown ether generally used as a ligand in coordination chemistry. It is also known as lithium ionophore because of its strong chelating property specific to lithium cation.

Purification Methods

The distilled crude product has to be recrystallised from pentane at -20o to remove acyclic material. It is then dried over P2O5. It complexes Li. [Anet et al. Acta Chem Scand 27 3395 1973, Beilstein 19/11 V 334.]

12-Crown-4 Preparation Products And Raw materials

Raw materials

Preparation Products

12-Crown-4 Suppliers

Global( 254)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21533	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29766	58
Xiamen AmoyChem Co., Ltd	+86-86-5926051114	sales@amoychem.com	China	6339	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-81139210 17389186172	1077@dideu.com	China	3999	58
Neostar United (Changzhou) Industrial Co., Ltd.	+86-0519-85551759	marketing1@neostarunited.com	China	8827	58
SIMAGCHEM CORP	+86-5922680277 +86-13806087780	sale@simagchem.com	China	17339	58
TargetMol Chemicals Inc.	+1-781-999-5354; +1-00000000000	marketing@targetmol.com	United States	32431	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +86-189 4982 3763	sales@tnjchem.com	China	34526	58
Shanghai UCHEM Inc.	+86-18930848214 +86-021-56762820	sales@myuchem.com	China	8926	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 17705817739	info@dycnchem.com	China	52693	58

Supplier	Advantage
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
Xiamen AmoyChem Co., Ltd	58
Shaanxi Dideu Medichem Co. Ltd	58
Neostar United (Changzhou) Industrial Co., Ltd.	58
SIMAGCHEM CORP	58
TargetMol Chemicals Inc.	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Shanghai UCHEM Inc.	58
Dayang Chem (Hangzhou) Co.,Ltd.	58

View Lastest Price from 12-Crown-4 manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-01-07	12-Crown-4 294-93-9			99%	100KG	Guangzhou CATO Research Chemicals Inc.
2021-07-02	12-Crown-4 294-93-9	$10.00-15.00	1KG	99%+ HPLC		Zhuozhou Wenxi import and Export Co., Ltd
2019-07-06	12-Crown-4 294-93-9	$7.00	1kg	99%	100KG	Career Henan Chemical Co

12-Crown-4
294-93-9
99%
Guangzhou CATO Research Chemicals Inc.

12-Crown-4
294-93-9
$10.00-15.00
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

12-Crown-4
294-93-9
$7.00
99%
Career Henan Chemical Co

12-Crown-4 Spectrum

12-Crown-4(294-93-9)MS 12-Crown-4(294-93-9)¹HNMR 12-Crown-4(294-93-9)¹³CNMR 12-Crown-4(294-93-9)IR1 12-Crown-4(294-93-9)Raman

294-93-9(12-Crown-4)Related Search:

1,7-DIAZA-12-CROWN-4,4,10-DIAZA-12-CROWN 4-ETHER BIS[(12-CROWN-4)METHYL] DODECYLMETHYLMALONATE 2-(HYDROXYMETHYL)-12-CROWN 4-ETHER 1-AZA-12-CROWN 4-ETHER,1-AZA-12-CROWN-4,AZA-12-CROWN-4,aza-12-crown-499.5+% BENZO-12-CROWN-4,BENZO-12-CROWN 4-ETHER,Benzo-12-crown-4, 99+%,BENZO-12-CROWN-4 98+%

1-aza-12-crown-5 TETRAAZA-12-CROWN-4 TETRAHYDROCHLORIDE CYCLODODECANE DOTA Cyclen

N-METHYLAZA-12-CROWN-4 4-TERT-BUTYL-CALIX[4]ARENE-CROWN-4-COMPLEX 1-BENZYL-1-AZA-12-CROWN-4,N-BENZYLAZA-12-CROWN-4 TETRAAZA-12-CROWN-4 TETRAHYDROGENSULFATE 12-Crown-4

Cyclohexyl-12-crown-4 Tetraaza 12-crown-4-tetraacetic acid derivative BIS[(12-CROWN-4)METHYL] 2,2-DIDODECYLMALONATE

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LITHIUM IONOPHORE V CROWN ETHER/12-CROWN-4 Eoct Ethylene oxide cyclic tetramer 1,4,7,10-TETRAOXYCYCLODODECANE 12-CROWN-4 1,4,7,10-Tetraoxacyclododecane, 12-Crown-4 12-Crown-4,97% CROWN ETHER/12-CROWN-4 FOR SYNTHESIS 12-Crown-4 Cyclic tetraMer of ethylene oxide which is specific for the lithiuM cation., 98% 12-Crown-4(1,4,7,10-Tetraoxacyclododecane) 12-Crown 4-Ether > 294-93-9 12-Crown-4 12 C 4 12C4 1,4,7,10-TETRAOXACYCLODODECANE 12-CROWN 4-ETHER 12-C-4 Crown 294-93-9 294-93-6 Chelation/Complexation Compounds Macrocycles for Host-Guest Chemistry Crown Ethers Synthetic Reagents Crown Ethers Functional Materials Macrocycles for Host-Guest Chemistry