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4-(2-Hydroxyethyl)-2,2-dimethyl-1,3-dioxolane

4-(2-Hydroxyethyl)-2,2-dimethyl-1,3-dioxolane structure

CAS No.: 5754-34-7

Chemical Name:: 4-(2-Hydroxyethyl)-2,2-dimethyl-1,3-dioxolane

Synonyms: 2-(2,2-Dimethyl-1,3-dioxolan-4-yl);2,2-dimethyl-1,3-dioxolane-4-ethanol;1,3-Dioxolane-4-ethanol, 2,2-diMethyl-;4-(2-HYDROXYETHYL)-2,2-DIMETHYL-1,3-DIO&;4-(2-Hydroxyethyl)-2,2-dimethyl-1,3-dioxolane;4-(2-Hydroxyethyl)-2,2-diMethyl-1,3-dioxolaMe;(RAC)-2-(2,2-DIMETHYL[1,3]DIOXOLANE-4YL)ETHANOL;4-(2-Hydroxyethyl)-2,2-diMethyl-1,3-dioxolane 98%;1,4-Benzenedicarboxylicacid,bis(5-methylethyl)ester;ETHYL 7-(4-CHLOROPHENYL)-4-(3,4-DIMETHOXYPHENYL)-2-METHYL-5-OXO-4,6,7,8-TETRAHYDRO-1H-QUINOLINE-3-CA

CBNumber:: CB8754365

Molecular Formula:: C7H14O3

Molecular Weight:: 146.18

MDL Number:: MFCD03701622

MOL File:: 5754-34-7.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-09-12 18:55:52

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4-(2-Hydroxyethyl)-2,2-dimethyl-1,3-dioxolane Properties

Boiling point	199-200 °C(lit.)
Density	1.031 g/mL at 25 °C(lit.)
refractive index	n20/D 1.4400(lit.)
Flash point	>230 °F
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
pka	14.80±0.10(Predicted)
Appearance	Colorless to light yellow Liquid
InChI	InChI=1S/C7H14O3/c1-7(2)9-5-6(10-7)3-4-8/h6,8H,3-5H2,1-2H3
InChIKey	YYEZYENJAMOWHW-UHFFFAOYSA-N
SMILES	O1CC(CCO)OC1(C)C
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P261-P305+P351+P338
PPE	Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
RIDADR	NA 1993 / PGIII
WGK Germany	3
Storage Class	10 - Combustible liquids

4-(2-Hydroxyethyl)-2,2-dimethyl-1,3-dioxolane price More Price(35)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	571466	4-(2-Hydroxyethyl)-2,2-dimethyl-1,3-dioxolane 89%	5754-34-7	5g	$120	2026-04-30	Buy
Sigma-Aldrich	571466	4-(2-Hydroxyethyl)-2,2-dimethyl-1,3-dioxolane 89%	5754-34-7	25g	$341	2026-04-30	Buy
TCI Chemical	D5914	2-(2,2-Dimethyl-1,3-dioxolan-4-yl)ethan-1-ol min. 90.0 %	5754-34-7	1G	$51	2026-04-30	Buy
TCI Chemical	D5914	2-(2,2-Dimethyl-1,3-dioxolan-4-yl)ethan-1-ol min. 90.0 %	5754-34-7	5G	$200	2026-04-30	Buy
Biosynth	FD167070	2-(2,2-Dimethyl-1,3-dioxolan-4-yl)ethan-1-ol	5754-34-7	2g	$217.68	2026-06-04	Buy

Product number	Packaging	Price	Buy
571466	5g	$120	Buy
571466	25g	$341	Buy
D5914	1G	$51	Buy
D5914	5G	$200	Buy
FD167070	2g	$217.68	Buy

4-(2-Hydroxyethyl)-2,2-dimethyl-1,3-dioxolane Chemical Properties, Uses, Production

Uses

2-(2,2-Dimethyl-1,3-dioxolan-4-yl)ethanol is used in preparation of cationic lipids and stealth lipids for treating a variety of disorders.

Synthesis

3068-00-6

67-64-1

4-(2-HYDROXYETHYL)-2,2-DIMETHYL-1,3-DIOXOLANE

5754-34-7

GENERAL STEPS: A mixture of 1,2,4-butanetriol (15 g, 141 mmol), acetone (100 mL, 1362 mmol), and p-toluenesulfonic acid monohydrate (700 mg, 3.68 mmol) was stirred for 16 hours at room temperature. Upon completion of the reaction, triethylamine (2 mL, 14.3 mmol) was added to the reaction mixture to neutralize the acidic catalyst and the mixture was subsequently concentrated. The resulting residue was purified by silica gel column chromatography (silica gel, eluting solvent: heptane/ethyl acetate = 1/0 → 1/1-1/3 gradient) to afford 4-(2-hydroxyethyl)-2,2-dimethyl-1,3-dioxolane (16.55 g, yield: 80.3%) as a colorless oil. 1H-NMR (400 MHz, CDCl3) δ ppm: 1.37 (3H, s), 1.43 (3H, s), 1.79-1.86 (2H, m), 2.18-2.24 (1H, br), 3.60 (1H, dd, J = 7.8 Hz), 3.76-3.86 (2H, m), 4.10 (1H, dd, J = 6.8 Hz), 4.23-4.32 (1H, m).

References

[1] Nucleosides, Nucleotides and Nucleic Acids, 2005, vol. 24, # 10-12, p. 1543 - 1568
[2] European Journal of Organic Chemistry, 2015, vol. 2015, # 27, p. 6075 - 6083
[3] Journal of Organic Chemistry, 1996, vol. 61, # 3, p. 831 - 837
[4] Tetrahedron Letters, 1999, vol. 40, # 2, p. 209 - 212
[5] Bioorganic and Medicinal Chemistry Letters, 1999, vol. 9, # 9, p. 1247 - 1250

4-(2-Hydroxyethyl)-2,2-dimethyl-1,3-dioxolane Preparation Products And Raw materials

Raw materials

1,2,4-Butanetriol Acetone

Preparation Products

1-Methylthymine

4-(2-Hydroxyethyl)-2,2-dimethyl-1,3-dioxolane Suppliers

Global Suppliers ( 86)

Supplier	Tel	Email	Country	ProdList	Advantage
Nanjing Norris-Pharm Technology Co., Ltd	13901585132	sales@norris-pharm.com	China	8869	55
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Tianjin heowns Biochemical Technology Co., Ltd.	400 638 7771	sales@heowns.com	China	14412	57
Tianjin Derchemist Science & Technology Co., Ltd.	22-58627059 13920586291	zdcomcon@126.com	China	4094	50
Hangzhou Sage Chemical Co., Ltd.	+86057186818502 13588463833	info@sagechem.com	China	10265	58
Shanghai Jian Chao Chemical Technology Co., Ltd.	150-2103-5486 18017383231	983544897@qq.com	China	9335	55
Bide Pharmatech Ltd.	400-164-7117 18317119277	product02@bidepharm.com	China	40000	60
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51389	80
DebyeTec.com Inc.	18086626237 18086626237	2693528373@qq.com	China	2935	56
NovoChemy Ltd.	86-(0)21-31261262 373522135	sales@novochemy.com	China	6491	58

Supplier	Advantage
Nanjing Norris-Pharm Technology Co., Ltd	55
Energy Chemical	61
Tianjin heowns Biochemical Technology Co., Ltd.	57
Tianjin Derchemist Science & Technology Co., Ltd.	50
Hangzhou Sage Chemical Co., Ltd.	58
Shanghai Jian Chao Chemical Technology Co., Ltd.	55
Bide Pharmatech Ltd.	60
Sigma-Aldrich	80
DebyeTec.com Inc.	56
NovoChemy Ltd.	58

View Latest Price from 4-(2-Hydroxyethyl)-2,2-dimethyl-1,3-dioxolane manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-04-04	4-(2-HYDROXYETHYL)-2,2-DIMETHYL-1,3-DIOXOLANE 5754-34-7		1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.
	2019-07-06	4-(2-HYDROXYETHYL)-2,2-DIMETHYL-1,3-DIOXOLANE 5754-34-7	$1.00	1KG	99%	20kg	Career Henan Chemical Co

4-(2-HYDROXYETHYL)-2,2-DIMETHYL-1,3-DIOXOLANE
5754-34-7
98%
Henan Aochuang Chemical Co.,Ltd.

4-(2-HYDROXYETHYL)-2,2-DIMETHYL-1,3-DIOXOLANE
5754-34-7
$1.00
99%
Career Henan Chemical Co

4-(2-Hydroxyethyl)-2,2-dimethyl-1,3-dioxolane Spectrum

4-(2-HYDROXYETHYL)-2,2-DIMETHYL-1,3-DIOXOLANE(5754-34-7)¹HNMR

5754-34-7 (4-(2-Hydroxyethyl)-2,2-dimethyl-1,3-dioxolane) Related Search:

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1of4

(RAC)-2-(2,2-DIMETHYL[1,3]DIOXOLANE-4YL)ETHANOL 4-(2-HYDROXYETHYL)-2,2-DIMETHYL-1,3-DIO& 2,2-dimethyl-1,3-dioxolane-4-ethanol 1,3-Dioxolane-4-ethanol, 2,2-diMethyl- 4-(2-Hydroxyethyl)-2,2-diMethyl-1,3-dioxolaMe 4-(2-Hydroxyethyl)-2,2-diMethyl-1,3-dioxolane 98% 2-(2,2-Dimethyl-1,3-dioxolan-4-yl) 1,4-Benzenedicarboxylicacid,bis(5-methylethyl)ester ETHYL 7-(4-CHLOROPHENYL)-4-(3,4-DIMETHOXYPHENYL)-2-METHYL-5-OXO-4,6,7,8-TETRAHYDRO-1H-QUINOLINE-3-CA 4-(2-Hydroxyethyl)-2,2-dimethyl-1,3-dioxolane 5754-34-7 Organic Building Blocks Oxygen Compounds C7 to C8 Alcohols Building Blocks