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4-(2-HYDROXYETHYL)-2,2-DIMETHYL-1,3-DIOXOLANE

4-(2-HYDROXYETHYL)-2,2-DIMETHYL-1,3-DIOXOLANE structure

CAS No.: 5754-34-7

Chemical Name:: 4-(2-HYDROXYETHYL)-2,2-DIMETHYL-1,3-DIOXOLANE

Synonyms: 2-(2,2-Dimethyl-1,3-dioxolan-4-yl);2,2-dimethyl-1,3-dioxolane-4-ethanol;1,3-Dioxolane-4-ethanol, 2,2-diMethyl-;4-(2-HYDROXYETHYL)-2,2-DIMETHYL-1,3-DIO&;4-(2-Hydroxyethyl)-2,2-diMethyl-1,3-dioxolaMe;4-(2-HYDROXYETHYL)-2,2-DIMETHYL-1,3-DIOXOLANE;(RAC)-2-(2,2-DIMETHYL[1,3]DIOXOLANE-4YL)ETHANOL;4-(2-Hydroxyethyl)-2,2-diMethyl-1,3-dioxolane 98%;1,4-Benzenedicarboxylicacid,bis(5-methylethyl)ester;ETHYL 7-(4-CHLOROPHENYL)-4-(3,4-DIMETHOXYPHENYL)-2-METHYL-5-OXO-4,6,7,8-TETRAHYDRO-1H-QUINOLINE-3-CA

CBNumber:: CB8754365

Molecular Formula:: C7H14O3

Molecular Weight:: 146.18

MDL Number:: MFCD03701622

MOL File:: 5754-34-7.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 05:29:45

Product description	Number	Pack Size	Price
4-(2-Hydroxyethyl)-2,2-dimethyl-1,3-dioxolane 89%	571466	5g	$120
4-(2-Hydroxyethyl)-2,2-dimethyl-1,3-dioxolane 89%	571466	25g	$341
2-(2,2-Dimethyl-1,3-dioxolan-4-yl)ethan-1-ol min. 90.0 %	D5914	1G	$51
2-(2,2-Dimethyl-1,3-dioxolan-4-yl)ethan-1-ol min. 90.0 %	D5914	5G	$200
2-(2,2-Dimethyl-1,3-dioxolan-4-yl)ethan-1-ol	FD167070	2g	$217.68
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4-(2-HYDROXYETHYL)-2,2-DIMETHYL-1,3-DIOXOLANE Properties

Boiling point	199-200 °C(lit.)
Density	1.031 g/mL at 25 °C(lit.)
refractive index	n20/D 1.4400(lit.)
Flash point	>230 °F
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
pka	14.80±0.10(Predicted)
Appearance	Colorless to light yellow Liquid
InChI	InChI=1S/C7H14O3/c1-7(2)9-5-6(10-7)3-4-8/h6,8H,3-5H2,1-2H3
InChIKey	YYEZYENJAMOWHW-UHFFFAOYSA-N
SMILES	O1CC(CCO)OC1(C)C
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P261-P305+P351+P338
PPE	Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
RIDADR	NA 1993 / PGIII
WGK Germany	3
Storage Class	10 - Combustible liquids

4-(2-HYDROXYETHYL)-2,2-DIMETHYL-1,3-DIOXOLANE price More Price(44)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	571466	4-(2-Hydroxyethyl)-2,2-dimethyl-1,3-dioxolane 89%	5754-34-7	5g	$120	2026-04-30	Buy
Sigma-Aldrich	571466	4-(2-Hydroxyethyl)-2,2-dimethyl-1,3-dioxolane 89%	5754-34-7	25g	$341	2026-04-30	Buy
TCI Chemical	D5914	2-(2,2-Dimethyl-1,3-dioxolan-4-yl)ethan-1-ol min. 90.0 %	5754-34-7	1G	$51	2026-04-30	Buy
TCI Chemical	D5914	2-(2,2-Dimethyl-1,3-dioxolan-4-yl)ethan-1-ol min. 90.0 %	5754-34-7	5G	$200	2026-04-30	Buy
Biosynth	FD167070	2-(2,2-Dimethyl-1,3-dioxolan-4-yl)ethan-1-ol	5754-34-7	2g	$217.68	2026-06-04	Buy

Product number	Packaging	Price	Buy
571466	5g	$120	Buy
571466	25g	$341	Buy
D5914	1G	$51	Buy
D5914	5G	$200	Buy
FD167070	2g	$217.68	Buy

4-(2-HYDROXYETHYL)-2,2-DIMETHYL-1,3-DIOXOLANE Chemical Properties,Uses,Production

Uses

2-(2,2-Dimethyl-1,3-dioxolan-4-yl)ethanol is used in preparation of cationic lipids and stealth lipids for treating a variety of disorders.

Synthesis

3068-00-6

67-64-1

4-(2-HYDROXYETHYL)-2,2-DIMETHYL-1,3-DIOXOLANE

5754-34-7

GENERAL STEPS: A mixture of 1,2,4-butanetriol (15 g, 141 mmol), acetone (100 mL, 1362 mmol), and p-toluenesulfonic acid monohydrate (700 mg, 3.68 mmol) was stirred for 16 hours at room temperature. Upon completion of the reaction, triethylamine (2 mL, 14.3 mmol) was added to the reaction mixture to neutralize the acidic catalyst and the mixture was subsequently concentrated. The resulting residue was purified by silica gel column chromatography (silica gel, eluting solvent: heptane/ethyl acetate = 1/0 → 1/1-1/3 gradient) to afford 4-(2-hydroxyethyl)-2,2-dimethyl-1,3-dioxolane (16.55 g, yield: 80.3%) as a colorless oil. 1H-NMR (400 MHz, CDCl3) δ ppm: 1.37 (3H, s), 1.43 (3H, s), 1.79-1.86 (2H, m), 2.18-2.24 (1H, br), 3.60 (1H, dd, J = 7.8 Hz), 3.76-3.86 (2H, m), 4.10 (1H, dd, J = 6.8 Hz), 4.23-4.32 (1H, m).

References

[1] Nucleosides, Nucleotides and Nucleic Acids, 2005, vol. 24, # 10-12, p. 1543 - 1568
[2] European Journal of Organic Chemistry, 2015, vol. 2015, # 27, p. 6075 - 6083
[3] Journal of Organic Chemistry, 1996, vol. 61, # 3, p. 831 - 837
[4] Tetrahedron Letters, 1999, vol. 40, # 2, p. 209 - 212
[5] Bioorganic and Medicinal Chemistry Letters, 1999, vol. 9, # 9, p. 1247 - 1250

4-(2-HYDROXYETHYL)-2,2-DIMETHYL-1,3-DIOXOLANE Preparation Products And Raw materials

Raw materials

1,2,4-Butanetriol Acetone

Preparation Products

1-METHYLTHYMINE

4-(2-HYDROXYETHYL)-2,2-DIMETHYL-1,3-DIOXOLANE Suppliers

Global( 86)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Nanjing Bicbiotechnology Co., Ltd	+86-2552131256 +86-18251840740	sales@bicbiotech.com	China	5994	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29812	58
CONIER CHEM AND PHARMA LIMITED		sales@conier.com	China	49979	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-87569266 +86-17392581500	1015@dideu.com	China	3861	58
Hubei Ipure Biology Co., Ltd	+8618062405514	ada@ipurechemical.com	China	10236	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +86-189 4982 3763	sales@tnjchem.com	China	34563	58
HONG KONG IPURE BIOLOGY CO.,LIMITED	86 18062405514 18062405514	ada@ipurechemical.com	CHINA	3461	58
Shanghai UCHEM Inc.	+86-18930848214 +86-021-56762820	sales@myuchem.com	China	8886	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 17705817739	info@dycnchem.com	China	52704	58

Supplier	Advantage
Nanjing Bicbiotechnology Co., Ltd	58
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
CONIER CHEM AND PHARMA LIMITED	58
Shaanxi Dideu Medichem Co. Ltd	58
Hubei Ipure Biology Co., Ltd	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
HONG KONG IPURE BIOLOGY CO.,LIMITED	58
Shanghai UCHEM Inc.	58
Dayang Chem (Hangzhou) Co.,Ltd.	58

View Lastest Price from 4-(2-HYDROXYETHYL)-2,2-DIMETHYL-1,3-DIOXOLANE manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-04-04	4-(2-HYDROXYETHYL)-2,2-DIMETHYL-1,3-DIOXOLANE 5754-34-7		1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.
	2019-07-06	4-(2-HYDROXYETHYL)-2,2-DIMETHYL-1,3-DIOXOLANE 5754-34-7	$1.00	1KG	99%	20kg	Career Henan Chemical Co

4-(2-HYDROXYETHYL)-2,2-DIMETHYL-1,3-DIOXOLANE
5754-34-7
98%
Henan Aochuang Chemical Co.,Ltd.

4-(2-HYDROXYETHYL)-2,2-DIMETHYL-1,3-DIOXOLANE
5754-34-7
$1.00
99%
Career Henan Chemical Co

4-(2-HYDROXYETHYL)-2,2-DIMETHYL-1,3-DIOXOLANE Spectrum

4-(2-HYDROXYETHYL)-2,2-DIMETHYL-1,3-DIOXOLANE(5754-34-7)¹HNMR

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4-(2-HYDROXYETHYL)-2,2-DIMETHYL-1,3-DIOXOLANE (RAC)-2-(2,2-DIMETHYL[1,3]DIOXOLANE-4YL)ETHANOL 4-(2-HYDROXYETHYL)-2,2-DIMETHYL-1,3-DIO& 2,2-dimethyl-1,3-dioxolane-4-ethanol 1,3-Dioxolane-4-ethanol, 2,2-diMethyl- 4-(2-Hydroxyethyl)-2,2-diMethyl-1,3-dioxolaMe 4-(2-Hydroxyethyl)-2,2-diMethyl-1,3-dioxolane 98% 2-(2,2-Dimethyl-1,3-dioxolan-4-yl) 1,4-Benzenedicarboxylicacid,bis(5-methylethyl)ester ETHYL 7-(4-CHLOROPHENYL)-4-(3,4-DIMETHOXYPHENYL)-2-METHYL-5-OXO-4,6,7,8-TETRAHYDRO-1H-QUINOLINE-3-CA 5754-34-7 Organic Building Blocks Oxygen Compounds C7 to C8 Alcohols Building Blocks