(S)-5-Amino-piperidin-2-one HCl
- CAS No.
- 672883-95-3
- Chemical Name:
- (S)-5-Amino-piperidin-2-one HCl
- Synonyms
- (S)-5-AMINO-PIPERIDIN-2-O;4-(S)-AMINO-D-VALEROLACTAM HCL;(S)-5-Amino-piperidin-2-one HCl;(S)-5-AMINOPIPERIDIN-2-ONE HYDROCHLORIDE;(5S)-5-aminopiperidin-2-one hydrochloride;(S)-4-Amino-delta-valerolactam hydrochloride;(5S)-5-Aminopiperidin-2-one . x hydrochloride;(S)-5-AMINO-PIPERIDIN-2-ONEHCL (MFCD03094719);2-Piperidinone, 5-amino-, monohydrochloride, (5S)-
- CBNumber:
- CB8768735
- Molecular Formula:
- C5H11ClN2O
- Molecular Weight:
- 150.61
- MDL Number:
- MFCD03094719
- MOL File:
- 672883-95-3.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H319 |
| Precautionary statements | P305+P351+P338 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| HS Code | 2933399990 |
(S)-5-Amino-piperidin-2-one HCl price More Price(20)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | XBB88395 | (5S)-5-Aminopiperidin-2-one hydrochloride | 672883-95-3 | 100mg | $326 | 2026-06-05 | Buy |
| Biosynth | XBB88395 | (5S)-5-Aminopiperidin-2-one hydrochloride | 672883-95-3 | 1g | $837.8 | 2026-06-05 | Buy |
| Apolloscientific | OR480824 | (5S)-5-Aminopiperidin-2-one hydrochloride 95% | 672883-95-3 | 1g | $613 | 2026-06-04 | Buy |
| Matrix Scientific | 201999 | (5S)-5-Aminopiperidin-2-one hydrochloride | 672883-95-3 | 5.00g | $2246 | 2026-05-18 | Buy |
| aablocks | AA00FB8C | (S)-5-Aminopiperidin-2-one hydrochloride 96% | 672883-95-3 | 250mg | $102 | 2026-05-28 | Buy |
(S)-5-Amino-piperidin-2-one HCl Chemical Properties, Uses, Production
Application
(S)-5-amino-piperidin-2-one hydrochloride is an organic intermediate that can be prepared from L-glutamic acid-5-methyl ester through a six-step reaction.
Synthesis
Starting with L-glutamic acid-5-methyl ester, it was first reacted with di-tert-butyl dicarbonate in a triethylamine/DMF system at 50°C for 1 hour, then incubated overnight at room temperature. Column chromatography yielded a Boc-protected intermediate. This intermediate was dissolved in THF, reduced at -10°C with N-methylmorpholine, ethyl chloroformate, and sodium borohydride, quenched with saturated ammonium chloride, and purified by extraction to obtain a hydroxyl intermediate. This hydroxyl intermediate was then reacted with p-toluenesulfonyl chloride and triethylamine in dichloromethane at room temperature, and column chromatography yielded a sulfonyloxy intermediate. Subsequently, it was heated with sodium azide in DMF at 50°C for 3 hours to purify an azide intermediate. The azide intermediate was dissolved in methanol and hydrogenated overnight under atmospheric pressure using a 10% palladium/carbon catalyst. The solvent was removed by filtration to obtain a cyclization product. Finally, the cyclization product was dissolved in ethanol, and acetyl chloride was added at 0°C. The mixture was stirred at room temperature for 1 hour, and the solvent was removed under reduced pressure to obtain (S)-5-amino-piperidin-2-one hcl.
(S)-5-Amino-piperidin-2-one HCl Preparation Products And Raw materials
Raw materials
Preparation Products
(S)-5-Amino-piperidin-2-one HCl Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Tetranov Biopharm | 13526569071 | sales@leadmedpharm.com | China | 7881 | 64 |
| Shanghai Holy Biohemdeviser Co., Ltd | 021-61551100 | China | 443 | 57 | |
| T&W GROUP | 021-61551611 13296011611 | contact@trustwe.com | China | 9884 | 58 |
| Shanghai Sheepchem Co., Ltd. | +86 (21) 6715-7650 | sheepchem@163.com | China | 993 | 60 |
| Cantotech Chemicals, Ltd. | 86-0755-86635001 | cantotech@126.com | China | 4554 | 55 |
| Zhengzhou TRIZ Pharmaceutical Technology Co., Ltd. | 19943855286 | 94644163@qq.com | China | 1934 | 56 |
| Shanghai HuanChuan Industry Co.,Ltd. | 021-61478794 | sales@hcshhai.com | China | 9781 | 50 |
| JW & Y Pharmlab Co., Ltd. | 021-64340559 | xinyu_shi@jwypharmlab.com.cn | China | 11999 | 58 |
| Zhengzhou AiXi Technology Co., Ltd. | 0371-56787280 13137706083 | m18539565376@163.com | China | 999 | 55 |
| Changzhou Hopschain Chemical Co.,Ltd. | 85528066 13775048983 | sales@hopschem.com | China | 31548 | 55 |
