3-Piperidinophenol
- CAS No.
- 27292-50-8
- Chemical Name:
- 3-Piperidinophenol
- Synonyms
- Nsc23894;3-Piperidinohenol;3-Piperidinophenol;3-(1-Piperidyl)phenol;3-(Piperidin-1-yl)phenol;Phenol, 3-(1-piperidinyl)-
- CBNumber:
- CB8779634
- Molecular Formula:
- C11H15NO
- Molecular Weight:
- 177.24
- MDL Number:
- MFCD00053001
- MOL File:
- 27292-50-8.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2933399990 |
3-Piperidinophenol price More Price(29)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR28533 | 3-Piperidinophenol >95% | 27292-50-8 | 100mg | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR28533 | 3-Piperidinophenol >95% | 27292-50-8 | 250mg | $24 | 2026-06-04 | Buy |
| Apolloscientific | OR28533 | 3-Piperidinophenol >95% | 27292-50-8 | 1g | $48 | 2026-06-04 | Buy |
| Apolloscientific | OR28533 | 3-Piperidinophenol >95% | 27292-50-8 | 5g | $195 | 2026-06-04 | Buy |
| Activate Scientific | AS39957 | 3-(Piperidin-1-yl)phenol 98% | 27292-50-8 | 1g | $87 | 2026-06-04 | Buy |
3-Piperidinophenol Chemical Properties,Uses,Production
Synthesis
110-89-4
591-20-8
27292-50-8
General procedure for the synthesis of 3-piperidinylphenol from hexahydropyridine and m-bromophenol: N-(3-hydroxyphenyl)piperidine Pd(OAc)2 (129 mg, 0.578 mmol) was added to a mixture of piperidine (2.95 g, 34.68 mmol) and 3-bromophenol (5.00 g, 28.90 mmol). Under nitrogen protection, 2,8,9-tri-tert-butyl-2,5,8,9-tetraaza-1-phosphabicyclo[3.3.3]undecane (397 mg, 1.16 mmol), LiHMDS (66.5 cm3, 1 M in THF), and anhydrous toluene (110 cm3) were added sequentially. The reaction mixture was heated to 80 °C, maintained for 18 h and subsequently cooled to room temperature. Water (50 cm3) was added for partitioning and the aqueous layer was extracted with toluene (3 x 30 cm3). The organic phases were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure to remove the solvent. Purification by column chromatography [eluent ratio 3:7 ethyl acetate/hexane (Rf = 0.4)] gave an off-white solid product (2.56 g, 50% yield). NMR hydrogen spectrum (250 MHz, CDCl3) δH: 7.11-7.04 (1H, m, aryl ring H), 6.52 (1H, d, J = 8 Hz, aryl ring H), 6.35 (1H, s, aryl ring H), 6.29 (1H, d, J = 8 Hz, aryl ring H), 5.84 (1H, bs, OH), 3.08 (4H, t, J = 5 Hz , 2 × CH2), 1.75-1.62 (4H, m, 2 × CH2), 1.60-1.50 (2H, m, CH2); NMR carbon spectra (62.5 MHz, CDCl3) δC: 156.7, 153.4, 130.0, 109.3, 107.4, 104.6, 51.0, 25.5, 24.2; IR spectra ( KBr) νmax/cm1: 3064, 2959, 2937, 2921, 2856, 1597, 1503, 1454, 1276, 1201, 1133, 1104, 971, 877; mass spectra (ESI) m/z: 178.12 (100%, [M + H]+).
References
[1] Advanced Synthesis and Catalysis, 2004, vol. 346, # 6, p. 611 - 616
[2] Patent: WO2010/67078, 2010, A2. Location in patent: Page/Page column 91
[3] Chemistry - A European Journal, 2009, vol. 15, # 12, p. 2742 - 2746
[4] Bioorganic and Medicinal Chemistry, 2013, vol. 21, # 22, p. 7107 - 7117
3-Piperidinophenol Preparation Products And Raw materials
Raw materials
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Preparation Products
3-Piperidinophenol Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Sunway Pharmaceutical Technology Co., Ltd | 13761987713 | hxzheng@sunwaypharm.cn | China | 8663 | 57 |
| Shanghai yirong biology science and technology co., ltd | 18049974220 | 3060526242@qq.com | China | 999 | 60 |
| 9ding chemical ( Shanghai) Limited | 4009209199 | sales@9dingchem.com | China | 18201 | 56 |
| Shanghai Raise Chemical Technology Co.,Ltd | +86-021-50935922 | China | 7854 | 55 | |
| Shanghai Run-Biotech Co., Ltd. | 021-57171705 13817537615 | sales@run-biotech.com | China | 2283 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Aikon International Limited | 025-66113011 19370895928 | qzhang@aikonchem.com | China | 15390 | 58 |
| Henan Alfachem Co.,Ltd. | 0371-55051623 18137891487 | 3983243027@qq.com | China | 9965 | 58 |
| Shanghai Maruhua Science and Technology Co. Ltd. | 18721745940 | sales2@api-chem.com | China | 1969 | 58 |
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