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TERT-BUTYL (4-NITROBENZYL)CARBAMATE

TERT-BUTYL (4-NITROBENZYL)CARBAMATE Structure
TERT-BUTYL (4-NITROBENZYL)CARBAMATE structure
CAS No.
94838-58-1
Chemical Name:
TERT-BUTYL (4-NITROBENZYL)CARBAMATE
Synonyms
N-Boc-4-nitrobenzylamine;TERT-BUTYL (4-NITROBENZYL)CARBAMATE;2-Methyl-2-propanyl (4-nitrobenzyl)carbamate;tert-butyl N-[(4-nitrophenyl)methyl]carbamate;Carbamic acid, N-[(4-nitrophenyl)methyl]-, 1,1-dimethylethyl ester
CBNumber:
CB8835552
Molecular Formula:
C12H16N2O4
Molecular Weight:
252.27
MDL Number:
MFCD09038178
MOL File:
94838-58-1.mol
MSDS File:
SDS
Last updated:2026-05-28 06:16:00
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TERT-BUTYL (4-NITROBENZYL)CARBAMATE Properties

Melting point 105-108 °C
Boiling point 408.8±28.0 °C(Predicted)
Density 1.187±0.06 g/cm3(Predicted)
storage temp. 2-8°C
pka 11.58±0.46(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

TERT-BUTYL (4-NITROBENZYL)CARBAMATE price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth UDA83858 tert-Butyl 4-nitrobenzylcarbamate 94838-58-1 10g $354 2026-06-05 Buy
aablocks AA0067FZ tert-Butyl 4-nitrobenzylcarbamate 95% 94838-58-1 1g $20 2026-05-28 Buy
aablocks AA0067FZ tert-Butyl 4-nitrobenzylcarbamate 95% 94838-58-1 5g $68 2026-05-28 Buy
aablocks AA0067FZ tert-Butyl 4-nitrobenzylcarbamate 98% 94838-58-1 25g $274 2026-05-28 Buy
aablocks AA0067FZ tert-Butyl 4-nitrobenzylcarbamate 98% 94838-58-1 100g $940 2026-05-28 Buy
Product number Packaging Price Buy
UDA83858 10g $354 Buy
AA0067FZ 1g $20 Buy
AA0067FZ 5g $68 Buy
AA0067FZ 25g $274 Buy
AA0067FZ 100g $940 Buy

TERT-BUTYL (4-NITROBENZYL)CARBAMATE Chemical Properties,Uses,Production

Synthesis

Di-tert-butyl dicarbonate

24424-99-5

4-Nitrobenzylamine hydrochloride

18600-42-5

TERT-BUTYL (4-NITROBENZYL)CARBAMATE

94838-58-1

Step 1: Preparation of tert-butyl 4-nitrobenzylcarbamate (C4) 4-Nitrobenzylamine hydrochloride (10 g, 53.0 mmol) was suspended in a mixed solvent of THF (150 mL) and water (13 mL) and cooled to 0 °C. Di-tert-butyl dicarbonate (11.6 g, 53.0 mmol) and N,N-diisopropylethylamine (27.7 mL, 159 mmol) were added sequentially under stirring. The reaction mixture was stirred at 0 °C for 30 min and then slowly warmed up to 25 °C and continued stirring for about 20 hours. Upon completion of the reaction, most of the THF was removed by concentration under reduced pressure. the residue was dissolved in EtOAc and washed sequentially with 1N HCl, saturated NaHCO3 solution and saturated NaCl solution. The organic phase was dried over anhydrous MgSO4, filtered and concentrated under reduced pressure to give the off-white solid product C4 (14.0 g, 99% yield). 1H NMR (400 MHz, d6-DMSO) δ: 8.16 (d, 2H), 7.55 (t, 1H), 7.46 (d, 2H), 4.21 (d, 2H), 1.36 (s, 9H).

References

[1] Patent: US2009/54395, 2009, A1. Location in patent: Page/Page column 48
[2] Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 24, p. 4389 - 4393
[3] European Journal of Medicinal Chemistry, 2014, vol. 80, p. 101 - 111
[4] Chemical Communications, 2014, vol. 50, # 97, p. 15305 - 15308
[5] Patent: US2016/264520, 2016, A1. Location in patent: Paragraph 0332; 0333; 0334; 0335

TERT-BUTYL (4-NITROBENZYL)CARBAMATE Preparation Products And Raw materials

Raw materials

Di-tert-butyl dicarbonate 4-Nitrobenzylamine hydrochloride 4-nitrobenzylamine Water Diethylamine
Tetrahydrofuran

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Preparation Products

TERT-BUTYL (4-NITROBENZYL)CARBAMATE Suppliers

Global( 31)Suppliers
Supplier Tel Email Country ProdList Advantage
Chengdu HappySyn Pharmaceutical Technology Co., Ltd. 85114309 18982182443 yangli@happysyn.com China 2283 55
Nantong MYBio-pharm. Co., Ltd. 0513-85921823 18662920231 sales@ntminyanmedical.com China 4545 58
ShangHai KenEn Chemical Technology Co., Ltd. 13120367189;18621755571 mychess007@163.com China 1994 55
Amadis Chemical Company Limited 571-89925085 sales@amadischem.com China 131885 58
Amatek Scientific Co. Ltd. 0512-56316828 400-867-5858;400-867-5858 info@amateksci.com China 28763 58
Aikon International Limited 025-66113011 19370895928 qzhang@aikonchem.com China 15390 58
3A Chemicals 400-668-9898 service@3achem.com China 20535 58
Aishilun biotechnology (Shanghai) co., LTD 021-50676523 18019098996 info@acelybio.com China 3950 58
Nantong puyue biomedical Co., Ltd 0513-0513-0513-89158300 18014392889 sales@puyerbiopharma.com China 4956 58
Shanghai Joiny Pharmaceutical Co.,Ltd. 13681955282 gyd@joiny-pharma.com China 431 58
Supplier Advantage
Chengdu HappySyn Pharmaceutical Technology Co., Ltd. 55
Nantong MYBio-pharm. Co., Ltd. 58
ShangHai KenEn Chemical Technology Co., Ltd. 55
Amadis Chemical Company Limited 58
Amatek Scientific Co. Ltd. 58
Aikon International Limited 58
3A Chemicals 58
Aishilun biotechnology (Shanghai) co., LTD 58
Nantong puyue biomedical Co., Ltd 58
Shanghai Joiny Pharmaceutical Co.,Ltd. 58

94838-58-1(TERT-BUTYL (4-NITROBENZYL)CARBAMATE)Related Search:

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TERT-BUTYL (4-NITROBENZYL)CARBAMATE tert-butyl N-[(4-nitrophenyl)methyl]carbamate N-Boc-4-nitrobenzylamine Carbamic acid, N-[(4-nitrophenyl)methyl]-, 1,1-dimethylethyl ester 2-Methyl-2-propanyl (4-nitrobenzyl)carbamate 94838-58-1