LY 344864
- CAS No.
- 186544-26-3
- Chemical Name:
- LY 344864
- Synonyms
- CS-660;Y344864;LY 344864;LY344864 HCL;LY344864;LY-344864;LY 344864 hydrochloride;LY 344864 hydrochloride, 5-HT1F agonist;(R)-N-[3-(Dimethylamino)-2,3,4,9-tetrahydro-1H-carbazol-6-yl]-4-fluorobenzamide;Benzamide, N-[(3R)-3-(dimethylamino)-2,3,4,9-tetrahydro-1H-carbazol-6-yl]-4-fluoro-;(R)-N-(3-(Dimethylamino)-2,3,4,9-tetrahydro-1H-carbazol-6-yl)-4-fluorobenzamide hydrochloride
- CBNumber:
- CB8847478
- Molecular Formula:
- C21H22FN3O
- Molecular Weight:
- 351.42
- MDL Number:
- MFCD07772184
- MOL File:
- 186544-26-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 471.9±45.0 °C(Predicted) |
|---|---|
| Density | 1.28±0.1 g/cm3(Predicted) |
| storage temp. | Store at +4°C |
| solubility | DMSO : ≥ 350 mg/mL (995.96 mM) |
| pka | 14.12±0.40(Predicted) |
| form | Powder |
| color | White to off-white |
| Water Solubility |
water: 10mM DMSO: 100mM |
| InChI | 1S/C21H22FN3O.ClH/c1-25(2)16-8-10-20-18(12-16)17-11-15(7-9-19(17)24-20)23-21(26)13-3-5-14(22)6-4-13;/h3-7,9,11,16,24H,8,10,12H2,1-2H3,(H,23,26);1H/t16-;/m1./s1 |
| InChIKey | OKUHLSYESBLBCP-PKLMIRHRSA-N |
| FDA UNII | L4WN6HH63L |
| UNSPSC Code | 12352200 |
LY 344864 price More Price(43)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 217523 | LY 344864 Hydrochloride (5-HT1F Serotonin Receptor Agonist, LY 344864, LY344864, LY-344864) ≥98%(HPLC) | 186544-26-3 | 10mg | $459 | 2026-06-03 | Buy |
| ChemScene | CS-1350 | LY 344864 98.59% | 186544-26-3 | 5mg | $76 | 2026-06-04 | Buy |
| ChemScene | CS-1350 | LY 344864 98.59% | 186544-26-3 | 10mg | $119 | 2026-06-04 | Buy |
| ChemScene | CS-1350 | LY 344864 98.59% | 186544-26-3 | 25mg | $260 | 2026-06-04 | Buy |
| ChemScene | CS-1350 | LY 344864 98.59% | 186544-26-3 | 50mg | $412 | 2026-06-04 | Buy |
LY 344864 Chemical Properties, Uses, Production
Uses
LY-344864 Hydrochloride is used as a selective 5-HTIF receptor agonist.
Biological Activity
Potent, selective 5-HT 1F receptor agonist (EC 50 = 3 nM). Displays > 80-fold selectivity over other 5-HT receptors (K i values are 0.006, 0.53, 0.55, 0.56, 1.42, 1.70, 3.50, 3.94 and 4.85 μ M for 5-HT 1F , 5-HT 1A , 5-HT 1B , 5-HT 1D , 5-HT 1E , 5-HT 2B , 5-HT 2C , 5-HT 2A and 5-HT 7 receptors respectively). Inhibits neurogenic dural inflammation in vivo following i.v. and oral administration.
in vivo
LY 344864 (0-10 ng/kg; p.o. or i.v.; once) inhibits neurogenic dural inflammation in rat migraine pain model[1].
LY 344864 (1 mg/kg; i.v.; once) can cross the blood brain barrier to some extent in rats[1].
LY 344864 (2 mg/kg; i.p.; daily for 14 days) attenuates dopaminergic neuron loss and improved behavioral endpoints in a Parkinson’s disease mouse model[2].
| Animal Model: | Male Wistar rats, migraine pain model[1] |
| Dosage: | 1-10 ng/kg (oral), 0.3-2 ng/kg (intravenous) |
| Administration: | Oral, 75 minutes before trigeminal stimulation or intravenous, 10 minutes before trigeminal stimulation |
| Result: | When given intravenously 10 minutes before stimulation, inhibited inflammation with an ID50 (median infective dose) of 0.6 ng/kg. When administered orally 75 minutes before trigeminal stimulation, an ID50 of 1.2 ng/kg was obtained. |
| Animal Model: | Male C57BL/6 mice, Parkinson’s disease model[2] |
| Dosage: | 2 mg/kg |
| Administration: | Intraperitoneal injection, daily for 14d beginning 7d post-lesion |
| Result: | Attenuated TH-ir loss in the striatum and substantia nigra compared to vehicle-treated lesioned animals, also increased locomotor activity in 6-hydroxydopamine lesioned mice, while vehicle treatment had no effect. |
IC 50
human 5-HT1F Receptor: 0.006 μM (Ki); human 5-HT1A Receptor: 0.530 μM (Ki); human 5-HT1B Receptor: 0.549 μM (Ki); human 5-HT1D Receptor: 0.575 μM (Ki); human 5-HT1E Receptor: 1.415 μM (Ki); human 5-HT2B Receptor: 1.695 μM (Ki); Human 5-HT2A Receptor: 3.499 μM (Ki); Human 5-HT3A Receptor: 3.935 mM (Ki); Human 5-HT7 Receptor: 4.851 μM (Ki); rat α2-adrenergic receptor: 3.69 μM (Ki); rat α1-adrenergic receptor: 5.06 μM (Ki)
LY 344864 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Chengdu NoVi Biotechnology Co., Ltd. | 028-81458053 | novibiotech@163.com sales@novi-biotech.com | China | 226 | 55 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4853 | 58 |
| Credit Asia Chemical Co., Ltd. | +86 (21) 61124340 | China | 9739 | 58 | |
| LETOPHARM LIMITED | +86-21-5821 5861 | sales@letopharm.com | China | 2374 | 58 |
| SPIRO PHARMA | eric_feng1954@126.com | China | 9239 | 55 | |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8435 | 60 |
| Pharmacodia (Beijing) Co.,Ltd | +86-400-851-9921 | sales@pharmacodia.com | China | 2308 | 55 |
