| Company Name: |
BOC Sciences |
| Tel: |
1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
- LY 344864
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- $35.00
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2026-07-22
- CAS:186544-26-3
- Purity: 98.00%
- Supply Ability: 10g
- LY 344864
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- $1.00
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2019-12-25
- CAS:186544-26-3
- Min. Order: 1g
- Purity: 99.99%
- Supply Ability: 200kg
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| | LY 344864 Basic information |
| Product Name: | LY 344864 | | Synonyms: | LY 344864;LY 344864 hydrochloride;N-[(3R)-3-(Dimethylamino)-2,3,4,9-tetrahydro-1H-carbazol-6-yl]-4-fluorobenzamidehydrochloride;(R)-N-[3-(Dimethylamino)-2,3,4,9-tetrahydro-1H-carbazol-6-yl]-4-fluorobenzamide;(R)-N-(3-(Dimethylamino)-2,3,4,9-tetrahydro-1H-carbazol-6-yl)-4-fluorobenzamide hydrochloride;LY344864 HCL;LY344864;LY-344864;CS-660 | | CAS: | 186544-26-3 | | MF: | C21H22FN3O | | MW: | 351.42 | | EINECS: | | | Product Categories: | Inhibitors | | Mol File: | 186544-26-3.mol |  |
| | LY 344864 Chemical Properties |
| Boiling point | 471.9±45.0 °C(Predicted) | | density | 1.28±0.1 g/cm3(Predicted) | | storage temp. | Store at +4°C | | solubility | DMSO : ≥ 350 mg/mL (995.96 mM) | | pka | 14.12±0.40(Predicted) | | form | Powder | | color | White to off-white | | Water Solubility | water: 10mM
DMSO: 100mM | | InChI | 1S/C21H22FN3O.ClH/c1-25(2)16-8-10-20-18(12-16)17-11-15(7-9-19(17)24-20)23-21(26)13-3-5-14(22)6-4-13;/h3-7,9,11,16,24H,8,10,12H2,1-2H3,(H,23,26);1H/t16-;/m1./s1 | | InChIKey | OKUHLSYESBLBCP-PKLMIRHRSA-N |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | LY 344864 Usage And Synthesis |
| Uses | LY-344864 Hydrochloride is used as a selective 5-HTIF receptor agonist. | | Biological Activity | Potent, selective 5-HT 1F receptor agonist (EC 50 = 3 nM). Displays > 80-fold selectivity over other 5-HT receptors (K i values are 0.006, 0.53, 0.55, 0.56, 1.42, 1.70, 3.50, 3.94 and 4.85 μ M for 5-HT 1F , 5-HT 1A , 5-HT 1B , 5-HT 1D , 5-HT 1E , 5-HT 2B , 5-HT 2C , 5-HT 2A and 5-HT 7 receptors respectively). Inhibits neurogenic dural inflammation in vivo following i.v. and oral administration. | | in vivo | LY 344864 (0-10 ng/kg; p.o. or i.v.; once) inhibits neurogenic dural inflammation in rat migraine pain model[1].
LY 344864 (1 mg/kg; i.v.; once) can cross the blood brain barrier to some extent in rats[1].
LY 344864 (2 mg/kg; i.p.; daily for 14 days) attenuates dopaminergic neuron loss and improved behavioral endpoints in a Parkinson’s disease mouse model[2]. | Animal Model: | Male Wistar rats, migraine pain model[1] | | Dosage: | 1-10 ng/kg (oral), 0.3-2 ng/kg (intravenous) | | Administration: | Oral, 75 minutes before trigeminal stimulation or intravenous, 10 minutes before trigeminal stimulation | | Result: | When given intravenously 10 minutes before stimulation, inhibited inflammation with an ID50 (median infective dose) of 0.6 ng/kg. When administered orally 75 minutes before trigeminal stimulation, an ID50 of 1.2 ng/kg was obtained. |
| Animal Model: | Male C57BL/6 mice, Parkinson’s disease model[2] | | Dosage: | 2 mg/kg | | Administration: | Intraperitoneal injection, daily for 14d beginning 7d post-lesion | | Result: | Attenuated TH-ir loss in the striatum and substantia nigra compared to vehicle-treated lesioned animals, also increased locomotor activity in 6-hydroxydopamine lesioned mice, while vehicle treatment had no effect. |
| | IC 50 | human 5-HT1F Receptor: 0.006 μM (Ki); human 5-HT1A Receptor: 0.530 μM (Ki); human 5-HT1B Receptor: 0.549 μM (Ki); human 5-HT1D Receptor: 0.575 μM (Ki); human 5-HT1E Receptor: 1.415 μM (Ki); human 5-HT2B Receptor: 1.695 μM (Ki); Human 5-HT2A Receptor: 3.499 μM (Ki); Human 5-HT3A Receptor: 3.935 mM (Ki); Human 5-HT7 Receptor: 4.851 μM (Ki); rat α2-adrenergic receptor: 3.69 μM (Ki); rat α1-adrenergic receptor: 5.06 μM (Ki) |
| | LY 344864 Preparation Products And Raw materials |
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