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ChemicalBook >> CAS DataBase List >>3,20-Dioxopregna-1,4,9(11),16-tetraen-21-yl acetate

3,20-Dioxopregna-1,4,9(11),16-tetraen-21-yl acetate

3,20-Dioxopregna-1,4,9(11),16-tetraen-21-yl acetate Structure
3,20-Dioxopregna-1,4,9(11),16-tetraen-21-yl acetate structure
CAS No.
37413-91-5
Chemical Name:
3,20-Dioxopregna-1,4,9(11),16-tetraen-21-yl acetate
Synonyms
21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione;21-hydroxypregna-1,4,9(11),16-tetraene-3,20-dione 21-acetate;2-((8S,10S,13S,14S)-10,13-DiMethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate;Acetate tetraene Matter;16-tetraen-21-yl;Tetraen Acetate(3TR);Tetraene acetate[3TR];Prednisone Impurity 12;Pregna-1,4,9(11),16-tetraen;Tetraen-acetic acid complex
CBNumber:
CB8855295
Molecular Formula:
C23H26O4
Molecular Weight:
366.45
MDL Number:
MFCD07783010
MOL File:
37413-91-5.mol
MSDS File:
SDS
Last updated:2026-05-28 03:36:20
Product description Number Pack Size Price
21-(Acetyloxy)-pregna-1,4,9(11),16-tetraene-3,20-dione TRC-A187430-50MG 50mg $129
21-(Acetyloxy)-pregna-1,4,9(11),16-tetraene-3,20-dione TRC-A187430-10MG 10mg $78
21-(Acetyloxy)-pregna-1,4,9(11),16-tetraene-3,20-dione TRC-A187430-100MG 100mg $154
21-(Acetyloxy)-pregna-1,4,9(11),16-tetraene-3,20-dione 001508 100mg $418
21-(Acetyloxy)-pregna-1,4,9(11),16-tetraene-3,20-dione FA17154 5g $207.7
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3,20-Dioxopregna-1,4,9(11),16-tetraen-21-yl acetate Properties

Melting point 173-175°C
Boiling point 534.6±50.0 °C(Predicted)
Density 1.21±0.1 g/cm3(Predicted)
storage temp. Sealed in dry,2-8°C
solubility DMSO: 100 mg/mL (272.89 mM)
form Solid
color White to Off-White
InChI InChI=1S/C23H26O4/c1-14(24)27-13-21(26)20-7-6-18-17-5-4-15-12-16(25)8-10-22(15,2)19(17)9-11-23(18,20)3/h7-10,12,17-18H,4-6,11,13H2,1-3H3/t17-,18-,22-,23-/m0/s1
InChIKey UFEOMHFPJREVTP-PTRHGPIFSA-N
SMILES C1(=O)C=C2[C@](C)(C=C1)C1[C@]([H])([C@@]3([H])[C@@](CC=1)(C)C(C(=O)COC(C)=O)=CC3)CC2

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)Health Hazard (GHS08)
GHS07,GHS08
Signal word  Warning
Hazard statements  H319-H332-H312-H315-H335-H302-H361
Precautionary statements  P201-P202-P281-P308+P313-P405-P501-P261-P271-P304+P340-P312-P264-P270-P301+P312-P330-P501-P264-P280-P305+P351+P338-P337+P313P-P280-P302+P352-P312-P322-P363-P501-P264-P280-P302+P352-P321-P332+P313-P362
REACH Registrations Active

3,20-Dioxopregna-1,4,9(11),16-tetraen-21-yl acetate price More Price(31)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC TRC-A187430-50MG 21-(Acetyloxy)-pregna-1,4,9(11),16-tetraene-3,20-dione 37413-91-5 50mg $129 2026-06-03 Buy
TRC TRC-A187430-10MG 21-(Acetyloxy)-pregna-1,4,9(11),16-tetraene-3,20-dione 37413-91-5 10mg $78 2026-06-03 Buy
TRC TRC-A187430-100MG 21-(Acetyloxy)-pregna-1,4,9(11),16-tetraene-3,20-dione 37413-91-5 100mg $154 2026-06-03 Buy
Usbiological 001508 21-(Acetyloxy)-pregna-1,4,9(11),16-tetraene-3,20-dione 37413-91-5 100mg $418 2026-06-03 Buy
Biosynth FA17154 21-(Acetyloxy)-pregna-1,4,9(11),16-tetraene-3,20-dione 37413-91-5 5g $207.7 2026-06-04 Buy
Product number Packaging Price Buy
TRC-A187430-50MG 50mg $129 Buy
TRC-A187430-10MG 10mg $78 Buy
TRC-A187430-100MG 100mg $154 Buy
001508 100mg $418 Buy
FA17154 5g $207.7 Buy

3,20-Dioxopregna-1,4,9(11),16-tetraen-21-yl acetate Chemical Properties,Uses,Production

Chemical Properties

White Solid

Uses

21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione is an intermediate of delta 9,11 steroids synthesis, for example, Vamorolone(HY-109017). The delta 9,11 steroids are modifications of glucocorticoids and has anti-inflammatory properties. The delta 9,11 steroids are agents for protection against cell damage (lipid peroxidation) and inhibition of neovascularization[1].

Synthesis

Deltacortinene Acetate (Predisolone Acetate IMpurity)

4380-55-6

3,20-Dioxopregna-1,4,9(11),16-tetraen-21-yl acetate

37413-91-5

Under nitrogen protection, 50 g (0.13 mol) pregnane-1,4,9(11)-triene-3,20-dione-17-hydroxy-21-acetate was added to a reaction vial with 200 mL of pyridine, cooled to -15 °C and stirred. Subsequently, 30 g of N-chlorosuccinimide (NCS) was added and 17.5 g (0.27 mol) of SO2 gas was slowly vented over a period of 1 h. The reaction temperature was controlled to not exceed -10°C. After completion of the venting, stirring was continued for half an hour. Upon completion of the reaction, the formation of a mixed solution containing δ16 steroidal compound (I) was confirmed by TLC monitoring. This mixed solution was poured into 300 mL of concentrated hydrochloric acid, 2000 mL of ice water was added, and left to stand for 2 hours to remove water-soluble impurities. After separating the aqueous layer, the organic layer was concentrated to get at least the amount of liquid, filtered to get a solid, and dried at 60 °C to obtain 47 g of δ16 steroidal compound (I). The purity of this δ16 steroidal compound (I) was 99% as determined by high performance liquid chromatography (HPLC).

References

[1] Erica K M Reeves, et al. VBP15: preclinical characterization of a novel anti-inflammatory delta 9,11 steroid. Bioorg Med Chem DOI:10.1016/j.bmc.2013.02.009

3,20-Dioxopregna-1,4,9(11),16-tetraen-21-yl acetate Preparation Products And Raw materials

Raw materials

Deltacortinene Acetate (Predisolone Acetate IMpurity)

Preparation Products

Triamcinolone acetonide 21-acetate 3,21-Bis(acetyloxy)pregna-1,3,5,9(11),16-pentaen-20-one (6α)-21-(Acetyloxy)-6-fluoropregna-1,4,9(11),16-tetraene-3,20-dione 16alpha,17,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione 21-acetate Prednisone Impurity 13

3,20-Dioxopregna-1,4,9(11),16-tetraen-21-yl acetate Suppliers

Global( 205)Suppliers
Supplier Tel Email Country ProdList Advantage
Nanjing Shizhou Biotechnology Co., Ltd
+86-15850508050 sean.lv@synzest.com China 323 58
Wuhan Fortuna Chemical Co., Ltd 		+86-27-59207850 info@fortunachem.com China 5998 58
Nantong Guangyuan Chemicl Co,Ltd 		+86-17331189928 admin@guyunchem.com China 611 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21531 55
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29766 58
Cangzhou Wanyou New Material Technology Co.,Ltd 		18631714998 sales@czwytech.com CHINA 898 58
Shanghai Longyu Biotechnology Co., Ltd. 		+8615821988213 info@longyupharma.com China 2411 58
CONIER CHEM AND PHARMA LIMITED 		sales@conier.com China 49906 58
SHANGHAI T&W PHARMACEUTICAL CO., LTD. 		+86-021-61551413 contact@trustwe.com China 5742 58
SIMAGCHEM CORP 		+86-5922680277 +86-13806087780 sale@simagchem.com China 17339 58
Supplier Advantage
Nanjing Shizhou Biotechnology Co., Ltd
58
Wuhan Fortuna Chemical Co., Ltd 		58
Nantong Guangyuan Chemicl Co,Ltd 		58
Henan Tianfu Chemical Co.,Ltd. 		55
career henan chemical co 		58
Cangzhou Wanyou New Material Technology Co.,Ltd 		58
Shanghai Longyu Biotechnology Co., Ltd. 		58
CONIER CHEM AND PHARMA LIMITED 		58
SHANGHAI T&W PHARMACEUTICAL CO., LTD. 		58
SIMAGCHEM CORP 		58

View Lastest Price from 3,20-Dioxopregna-1,4,9(11),16-tetraen-21-yl acetate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
21-(Acetyloxy)-pregna-1,4,9(11),16-tetraene-3,20-dione pictures 2026-08-07 21-(Acetyloxy)-pregna-1,4,9(11),16-tetraene-3,20-dione
37413-91-5
 1KG 98%min 30tons/month WUHAN FORTUNA CHEMICAL CO., LTD
tetraene acetate pictures 2026-06-30 tetraene acetate
37413-91-5
 1KG 98.0% 10000KGS Shaanxi Dideu New Materials Co. Ltd
3,20-Dioxopregna-1,4,9(11),16-tetraen-21-yl acetate pictures 2025-11-18 3,20-Dioxopregna-1,4,9(11),16-tetraen-21-yl acetate
37413-91-5
 $1.10 1g 99.0% Min 100 Tons Dideu Industries Group Limited

37413-91-5(3,20-Dioxopregna-1,4,9(11),16-tetraen-21-yl acetate)Related Search:

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Pregna-1,4,9(11),16-tetraen-21-ol-3,20-dione 21-acetate 21-Acetoxypregna-1,4,9(11),16-tetrene-3,20-dione 3,20-Dioxopregna-1,4,9(11),16-tetrene-21-ol acetate 21-(Acetyloxy)-pregna-1,4,9(11),16-tetraene-3,20-dione Pregna-1,4,9(11),16-tetraene-3,20-dione,21-(acetyloxy)- Acetate tetraene Matter Tetraen-acetic acid complex 21-hydroxypregna-1,4,9(11),16-tetraene-3,20-dione 21-acetate [2-[(8S,10S,13S,14S)-10,13-dimethyl-3-oxo-6,7,8,12,14,15-hexahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate 3,20-dioxopregna-1,4,9(11),16-tetraen-21-yl acetate Pregna-1,4,9(11),16-tetraen 16-tetraen-21-yl Prednisone Impurity 12 Prednisolone impurity 8/21-(Acetyloxy)-pregna-1,4,9(11),16-tetraene-3,20-dione Tetraene acetate[3TR] 1,4,9(11),16-PREGNATETRAENE-21-OL-3,20-DIONE-21-ACETATE(3TR) CAS#37413-91-5 3,20-Dioxopregna-1,4,9(11),16-tetraen-21-yl acetate ISO 9001：2015 REACH 21-Hydroxy-1,4,9(11)-tetraene 21-acetate Mometasone Related Compound 4 21-hydroxyprogesterone-1,4,9 (11), 16-tetraene-3,20-dione-21-acetate Tetraen Acetate(3TR) 1,4,9(11),16-Prenatetraene-21-ol-3,20-dione-17-acetate 21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione - [A72270] 2-((8S,10S,13S,14S)-10,13-DiMethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate 21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione 37413-91-5 Intermediates & Fine Chemicals Pharmaceuticals Steroids 37413-91-5