Clethodim
- CAS No.
- 99129-21-2
- Chemical Name:
- Clethodim
- Synonyms
- SELECT(R);2-[1-[[[(2E)-3-Chloro-2-propen-1-yl]oxy]iMino]propyl]-5-[2-(ethylthio)propyl]-3-hydroxy-2-cyclohexen-1-one;Ogive;re45601;ethodim;PRISM(R);RH 45601;CLETHODIM;Centurion;Volunteer
- CBNumber:
- CB4404330
- Molecular Formula:
- C17H26ClNO3S
- Molecular Weight:
- 359.91
- MDL Number:
- MFCD01632327
- MOL File:
- 99129-21-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | <25 °C |
|---|---|
| Boiling point | 472.6±55.0 °C(Predicted) |
| Density | 1.18±0.1 g/cm3(Predicted) |
| storage temp. | 0-6°C |
| solubility | Chloroform (Sparingly, Sonicated), Ethyl Acetate (Slightly), Methanol (Sparingly |
| pka | 4.28±0.25(Predicted) |
| form | Liquid |
| color | Light Yellow to Dark Yellow |
| Henry's Law Constant | 8.2×105 mol/(m3Pa) at 25℃, HSDB (2015) |
| Stability | Hygroscopic |
| Major Application |
agriculture environmental |
| InChI | InChI=1S/C17H26ClNO3S/c1-4-14(19-22-8-6-7-18)17-15(20)10-13(11-16(17)21)9-12(3)23-5-2/h6-7,12-13,20H,4-5,8-11H2,1-3H3/b7-6+,19-14 |
| InChIKey | SILSDTWXNBZOGF-JWGBMQLESA-N |
| SMILES | C1(=O)CC(CC(SCC)C)CC(O)=C1C(=NOC/C=C/Cl)CC |
| CAS DataBase Reference | 99129-21-2(CAS DataBase Reference) |
| FDA UNII | 05SB62IB6F |
| Pesticides Freedom of Information Act (FOIA) | Clethodim |
| EPA Substance Registry System | Clethodim (99129-21-2) |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H317 |
| Precautionary statements | P261-P264-P270-P280-P301+P312-P302+P352 |
| PPE | Eyeshields, Gloves |
| Safety Statements | 22-24/25 |
| RIDADR | UN3082 (environmentally haz- ardous substances, liquid, n. o. s.) |
| WGK Germany | 3 |
| HS Code | 29309090 |
| Storage Class | 10 - Combustible liquids |
| Hazard Classifications | Acute Tox. 4 Oral Aquatic Chronic 3 Skin Sens. 1 |
| Hazardous Substances Data | 99129-21-2(Hazardous Substances Data) |
| Toxicity | LD50 in male, female rats (mg/kg): 1630, 1360 orally; LC50 in trout: 56 mg/l; 8 day feeding in quail: > 6000 ppm (Kincade) |
Clethodim price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 34190 | Clethodim PESTANAL | 99129-21-2 | 50mg | $224 | 2026-04-30 | Buy |
| TRC | TRC-C573250-50MG | Clethodim >95%(HPLC) | 99129-21-2 | 50mg | $109 | 2026-06-03 | Buy |
| TRC | TRC-C573250-250MG | Clethodim >95%(HPLC) | 99129-21-2 | 250mg | $348 | 2026-06-03 | Buy |
| TRC | TRC-C573250-100MG | Clethodim >95%(HPLC) | 99129-21-2 | 100mg | $157 | 2026-06-03 | Buy |
| Usbiological | 006923 | Clethodim | 99129-21-2 | 50mg | $502 | 2026-06-03 | Buy |
Clethodim Chemical Properties, Uses, Production
Physical and chemical properties
The original medicine is amber transparent liquid with relative density 1.14 (20 ℃) and vapor pressure <1 × 10-2mPa (20 ℃). It is soluble in most organic solvents, stable under ultraviolet light, but unstable at extreme pH.
Toxicity
The acute oral toxicity of original medicine LD50 in rats was 1360 mg / kg (female) , 1630 mg / kg (male). The acute dermal toxicity LD(50) in rabbits was more than 5g/kg. The acute inhalation LC50 in rats (4 hours) is more than 4.6mg/L . No effect dose during Feeding test: rat 16mg / kg • d, mice 30mg / kg • d. ADI by humans is 0.01 mg / kg. The acute oral toxicity LD50 in quails is more than 2g / kg. The acute inhalation LC50 (8 days) in wild ducks and quails is more than 6g / kg. The LC50 in daphnias is > 120mg / L. The LD50 in insects is 454 mg / kg. The LC50 in blue gill fish (96 hours)is > 120mg / L, The LC50 in rainbow trout is 5056mg / L. The LD50 in bees is > 100μg per bee.
Mode of action
It is a selective, systemic post-emergence herbicide which can be rapidly absorbed by plant leaves and conducted to roots and growing points to inhibit the biosynthesis of plant branched-chain fatty acids. The target weeds then grow slowly and lose competitiveness with seedling tissue early yellowing and followed by the remaining leaves wilting. Finally they will die.
Target plants
Suitable for broad-leaf plants. All tested plants of non-grass family were highly resistant to RE-45601 throughout the entire growth and development period, even applied with 2 kg ai / hm2 (8-20 times higher than herbicides) plus vegetable oil 2.341 / hm2, the situation still remains the same.
Soybeans and cotton can be sowed immediately after application of RE-45601. Other crops can be sowed 4 months after application of RE-45601 at a dose of 1.12 kg ai / hm2 or less.
Application
Applicable to annual and perennial grass weeds and many Field maize cereals withbroad-leaf. (1) annual species (84-140 g ai / hm2): Kusamiligus ostreatus, wild oats, wool millet, brachiopod, mangrove, black brome, ryegrass, gall grass, French foxtail, hemostatic horse, Golden Foxtail, Crabgrass, Setaria viridis, Echinochloa crus-galli, Dichromatic Sorghum, Barnyardgrass, Wheat, Lemna, Corn; Barley , (2) Arabian sorghum of perennial species (84-140 g ai / hm2); (3) Perennial species (140 ~ 280g ai / hm2) bermudagrass, creeping wild wheat.
It’s not or slightly active against broad-leaf weeds or Carex. The crops of grass family such as barley, corn, oats, rice, sorghum and wheat are all susceptible to RE-45601. Therefore the autogenesis plants in the filed where crops of non-grass family can be controlled with RE-45601.
How to use
RE-45601 gets the best control effect during the period when grass weeds grow vigorously. Drought, low temperature (below 15 ° C) and other unfavorable factors sometimes reduce the activity of RE-45601. For annual weeds of grass family, it should be applied during the 3 to 5 leaf stage. For perennial weeds of grass family, herbicide should be applied after weeds tillering; increase of the dose or number of applications is needed for non- appropriate period for spraying. If an even distribution of droplets can be applied, low spray volume (ie 50L / hm2)is more effective than the high spray volume (180 ~ 280L / hm2). The biological activity can be improved by adding vegetable oil 2.34L / hm2. The active ingredient in RE-45601 is absorbed by plants within 1 hour, so the rainfall after application will not reduce the effect.
Preparation Methods
5-alkylcyclohexanedione-3-carboxylate is produced by the condensation and cyclization of the corresponding ketene and diethyl malonatein the presence of sodium hydroxide, then compound(Ⅰ) is obtained by hydrolysis and decarboxylation, followed by its reaction with propionyl chloride to form 3-propionyloxy-5-alkylcyclohexenone which is soluble in methylene chloride . then has isomerization reaction in the presence of aluminum trichloride and finally reacts with H2NOCH2CH = CHCl to produce,clethodim. The response equation is as follows:
Description
Clethodim is a herbicide that is used to control annual and perennial grasses. It is highly soluble in water and has a low volatility. It tends not to be persistent in soil or aquatic systems. It is moderately toxic to birds, fish, aquatic plants, honeybees and earthworms but is less toxic to aquatic invertebrates and algae. Clethodim is moderately toxic to mammals and whilst it is a skin irritant no evidence of it causing more serious health effects have been found.
Chemical Properties
Clear Yellow Oil
Uses
Systemic graminicide. Post-emergent herbicide.
Production Methods
The commercial production of clethodim involves a multi-step synthetic process built around constructing its cyclohexenone core and attaching key functional groups. One efficient route begins with the synthesis of the intermediate (E)-O-(3-chloro-2-propenyl)hydroxylamine, which is prepared via a continuous flow process from hydroxylamine hydrochloride, streamlining reaction time and improving safety. This intermediate is then coupled with a substituted cyclohexenone derivative, typically through condensation and acylation reactions, to form the final clethodim molecule. Alternative methods involve reacting 3,4-dihydro-3-methyl-2H-1,4-benzoxazine with dichloroacetyl chloride under reflux, followed by distillation and recrystallisation to yield high-purity clethodim.
Definition
ChEBI: Clethodim is an oxime O-ether resulting from the formal conversion ot the acyclic keto group of 5-[2-(ethylsulfanyl)propyl]-3-hydroxy-2-propionylcyclohex-2-en-1-one to the corresponding oxime with subsequent O-alkylation of the oxime by an (E)-3-chloroallyl group. It is used as a selective postemergence herbicide for the control of annual and perennial grasses in numerous crops, including alfalfa, celery, clover, conifers, cotton, cranberries, garlic, onions, ornamentals, peanuts, soybeans, strawberries, sugarbeet, sunflowers, and vegetables; the (-)-enantiomer has been reported to be more active than the (+)-enantiomer. It has a role as a herbicide and an EC 6.4.1.2 (acetyl-CoA carboxylase) inhibitor. It is an organic sulfide, a cyclic ketone, an organochlorine compound, an oxime O-ether, a beta-diketone and an enol.
Agricultural Uses
Herbicide: Not approved for use in EU countries. A selective post-emergence herbicide used to control annual and perennial grasses to a range of crops including cotton, flax, peanuts, soybeans, sugarbeets, potatoes, alfalfa, sunflowers and most vegetables.
Trade name
CLETODIME®; PRISM®; RE 45601; SELECT®
Pesticide Type
Herbicide
Clethodim Preparation Products And Raw materials
Raw materials
1of3
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Xibiao (Shanghai) Technology Co., Ltd | 18512111473 18512111473 | 2238774038@qq.com | China | 3149 | 58 |
| Jiangsu Agrochem Laboratory | -- | sales@agrochemlab.com | China | 204 | 54 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Rudong Zhongyi Chemical Co., Ltd | 13306234115 | jszyzj@zhongyichem.com | China | 36 | 60 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| S.Z. PhyStandard Bio-Tech. Co., Ltd. | 0755-83725681-603 | China | 4484 | 50 | |
| Shanghai Topbiochem Technology Co., Ltd | 021-58170097 | info@topbiochem.com | China | 9509 | 58 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4773 | 55 |
| Nanjing Sunlida Biological Technology Co., Ltd. | 025-57798810 18652991625 | sales@sunlidabio.com | China | 3223 | 55 |
View Latest Price from Clethodim manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-14 | clethodim
99129-21-2
|
1kg | 99 | 20tons | Qingdao Trust Agri Chemical Co.,Ltd | ||
 |
2025-02-13 | Clethodim
99129-21-2
|
$7.00-10.00 | 1kg | 99.99% | 10 tons | Shandong Deshang Chemical Co., Ltd. | |
 |
2021-11-15 | Clethodim
99129-21-2
|
$3.00 | 1KG | 99% | 5ton/Month | Qiuxian Baitai New Material Co., LTD |
