1-Benzyl 2-(tert-butyl) hydrazine-1,2-dicarboxylate
- CAS No.
- 57699-88-4
- Chemical Name:
- 1-Benzyl 2-(tert-butyl) hydrazine-1,2-dicarboxylate
- Synonyms
- 1-Boc-2-Cbz-hydrazine;N-Boc-N'-Cbz-hydrazine;N-Boc-N’-Cbz-hydrazine;Hydrazine, N-BOC, N'-CBZ protected;1-benzyl 2-(tert-butyl) 1,2-hydrazinedicarboxylate;1-Benzyl 2-(tert-butyl) hydrazine-1,2-dicarboxylate;benzyl N-[(2-methylpropan-2-yl)oxycarbonylamino]carbamate;1,2-Hydrazinedicarboxylic acid, 1-(1,1-diMethylethyl) 2-(phenylMethyl) ester
- CBNumber:
- CB8956291
- Molecular Formula:
- C13H18N2O4
- Molecular Weight:
- 266.29
- MDL Number:
- MFCD09752862
- MOL File:
- 57699-88-4.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H332-H335 |
| Precautionary statements | P261-P280-P305+P351+P338 |
| Hazard Codes | Xi |
| HazardClass | IRRITANT |
| HS Code | 2928009090 |
1-Benzyl 2-(tert-butyl) hydrazine-1,2-dicarboxylate price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Activate Scientific | AS33847 | 1-Boc-2-Cbz-hydrazine 97% | 57699-88-4 | 1g | $23 | 2026-06-04 | Buy |
| Activate Scientific | AS33847 | 1-Boc-2-Cbz-hydrazine 97% | 57699-88-4 | 5g | $71 | 2026-06-04 | Buy |
| Activate Scientific | AS33847 | 1-Boc-2-Cbz-hydrazine 97% | 57699-88-4 | 25g | $223 | 2026-06-04 | Buy |
| Apolloscientific | OR12453 | Hydrazine, N-BOC, N'-CBZ protected ≥95% | 57699-88-4 | 1g | $21 | 2026-06-04 | Buy |
| AK Scientific | W7105 | 1-Benzyl 2-(tert-butyl) hydrazine-1,2-dicarboxylate 98%(HPLC) | 57699-88-4 | 1g | $28 | 2026-06-04 | Buy |
1-Benzyl 2-(tert-butyl) hydrazine-1,2-dicarboxylate Chemical Properties, Uses, Production
Uses
1-Benzyl 2-(tert-Butyl) Hydrazine-1,2-dicarboxylate is a useful intermediate for the preparation of some α-aza-amino-acid derivatives used in peptide synthesis.
Synthesis
870-46-2
501-53-1
57699-88-4
Benzyl chloroformate (Benzyl chloroformate) was slowly added to a solution of tert-butyl carbazate (tert-Butyl carbazate, 75 g, 567 mmol) in dichloromethane (Dichloromethane, 2.0 L) at 0 °C, and the addition time was controlled to be within 45 min. After the addition was completed, the reaction mixture was stirred at 0 °C overnight and allowed to warm up to room temperature naturally in an ice bath. Upon completion of the reaction, the reaction mixture was carefully poured into saturated sodium bicarbonate solution (1 L) for neutralization, followed by extraction with dichloromethane. The organic layer was washed with water and dried with anhydrous sodium sulfate. The solvent was removed by distillation under reduced pressure to afford the crude product 2-(tert-butyl)hydrazine-1,2-dicarboxylic acid-1-benzyl ester (148 g, 556 mmol, 98% yield) as a viscous oil. After preliminary analysis, the purity of the product meets the requirements for subsequent use without further purification.
References
[1] Patent: WO2008/65500, 2008, A2. Location in patent: Page/Page column 67
[2] Tetrahedron, 2010, vol. 66, # 49, p. 9538 - 9544
[3] Tetrahedron Letters, 1992, vol. 33, # 36, p. 5209 - 5212
[4] Tetrahedron Letters, 2007, vol. 48, # 33, p. 5767 - 5770
[5] Journal of the American Chemical Society, 2004, vol. 126, # 21, p. 6759 - 6764
1-Benzyl 2-(tert-butyl) hydrazine-1,2-dicarboxylate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Shanghai Sunway Pharmaceutical Technology Co., Ltd | 13761987713 | hxzheng@sunwaypharm.cn | China | 8663 | 57 |
| Chengdu HappySyn Pharmaceutical Technology Co., Ltd. | 85114309 18982182443 | yangli@happysyn.com | China | 2297 | 55 |
| Shanghai Topbiochem Technology Co., Ltd | +86-21-60341587 | sales@topbiochem.com | China | 6166 | 58 |
| SuZhou ShiYa Biopharmaceuticals, Inc. | 86(512)5235 8471 17715136450 | sales@shiyabiopharm.com | China | 4167 | 58 |
| SynAsst Chemical. | 021-60343070 | China | 12731 | 55 | |
| Shanghai Yolne Chemical Co., Ltd. | 021-62960152 | 934678158@qq.com | China | 9886 | 55 |
View Latest Price from 1-Benzyl 2-(tert-butyl) hydrazine-1,2-dicarboxylate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2019-12-23 | 1-Benzyl 2-(tert-butyl) hydrazine-1,2-dicarboxylate
57699-88-4
|
$1.00 | 1KG | 99% | 100KG | Career Henan Chemical Co |
-
- 1-Benzyl 2-(tert-butyl) hydrazine-1,2-dicarboxylate
57699-88-4
- $1.00
- 99%
- Career Henan Chemical Co
