4-Methoxy-1H-quinolin-2-one
- CAS No.
- 27667-34-1
- Chemical Name:
- 4-Methoxy-1H-quinolin-2-one
- Synonyms
- 4-Methoxy-2-quinolinone;4-Methoxy-quinolin-2-ol;4-Methoxy-1H-quinolin-2-one;2(1H)-Quinolinone, 4-methoxy-
- CBNumber:
- CB8958437
- Molecular Formula:
- C10H9NO2
- Molecular Weight:
- 175.18
- MDL Number:
- MFCD01463823
- MOL File:
- 27667-34-1.mol
- MSDS File:
- SDS
| Melting point | 271 °C |
|---|---|
| Boiling point | 124 °C(Press: 8 Torr) |
| Density | 1.24±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| form | solid |
| pka | 10.86±0.70(Predicted) |
| Appearance | White to yellow Solid |
| InChI | 1S/C10H9NO2/c1-13-9-6-10(12)11-8-5-3-2-4-7(8)9/h2-6H,1H3,(H,11,12) |
| InChIKey | LJYFMHAOCYPGMX-UHFFFAOYSA-N |
| UNSPSC Code | 12352200 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P264-P280-P332+P313-P337+P313-P362+P364 |
| WGK Germany | WGK 3 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 |
4-Methoxy-1H-quinolin-2-one price More Price(20)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PH018693 | 4-Methoxy-2(1H)-quinolinone AldrichCPR | 27667-34-1 | 1g | $201 | 2023-06-20 | Buy |
| aablocks | AA002UAD | 4-Methoxyquinolin-2(1H)-one 95% | 27667-34-1 | 100mg | $20 | 2026-05-28 | Buy |
| aablocks | AA002UAD | 4-Methoxyquinolin-2(1H)-one 95% | 27667-34-1 | 250mg | $22 | 2026-05-28 | Buy |
| aablocks | AA002UAD | 4-Methoxyquinolin-2(1H)-one 95% | 27667-34-1 | 1g | $85 | 2026-05-28 | Buy |
| Crysdot | CD11154768 | 4-Methoxyquinolin-2(1H)-one 95+% | 27667-34-1 | 1g | $233 | 2026-05-26 | Buy |
4-Methoxy-1H-quinolin-2-one Chemical Properties, Uses, Production
Synthesis
70254-44-3
27667-34-1
General procedure for the synthesis of 4-methoxy-2-quinolinone from 2-hydroxyquinolin-4(1H)-one: to a suspension of 2,4-dihydroxyquinoline (3.00 g, 18.6 mmol) and potassium carbonate (5.14 g, 37.2 mmol) in acetone (500 mL) was added dropwise dimethyl sulfate (2.1 mL). The reaction mixture was heated to reflux for 5 hours. Upon completion of the reaction, the solvent was removed by vacuum distillation and the residue was ground with an appropriate amount of water. The crude product was collected by filtration, washed with water and subsequently purified by grinding with methanol to afford 4-methoxy-2-quinolinone (1.76 g, 54% yield) as a white solid. The 1H NMR data of the product were in agreement with literature reports (Reisch et al., Arch. Pharm., 1980, 313, 751-755).
References
[1] Patent: US2003/207868, 2003, A1
[2] Patent: US2002/99208, 2002, A1
4-Methoxy-1H-quinolin-2-one Preparation Products And Raw materials
Raw materials
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Preparation Products
4-Methoxy-1H-quinolin-2-one Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| SynAsst Chemical. | 021-60343070 | China | 12731 | 55 | |
| Hangzhou Trylead Chemical Technology Co.,LTD | 0571-87086220 13516718938 | zyf@trylead-chem.com | China | 300 | 64 |
| Finetech Industry Limited | 027-87465837 19945049750 | sales@finetechnology-ind.com | China | 9331 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| ShangHai Wisacheam Pharmaceutical Co., Ltd. | 13817485796 | tim@wisacheampharm.com | China | 3698 | 58 |
| SuZhou ShiYa Biopharmaceuticals, Inc. | 0512-0512-52358471 17715136450 | sales@shiyabiopharm.com | China | 9814 | 58 |
| Shanghai Huaxing Biological Technology Co., Ltd. | 18621295758; 18621295758 | 1449085402@qq.com | China | 1973 | 55 |
| Aikon International Limited | 025-66061636 19370895928 | qqyang@aikonchem.com | China | 15810 | 58 |
| Suzhou Nuoouman Biological Technology Co., Ltd. | 15026866316 | 180642609@qq.com | China | 4967 | 58 |
| SHANGHAI FDC-CHEMICAL CO.,LTD | 021-61469567 13774476675 | sales@fdc-chemical.com | China | 9999 | 58 |
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