VU6007477
- CAS No.
- 2220141-46-6
- Chemical Name:
- VU6007477
- Synonyms
- VU6007477;1H-Pyrrolo[2,3-b]pyridine-6-carboxamide, 1-methyl-4-[[6-(1-methyl-1H-pyrazol-4-yl)-3-pyridinyl]methyl]-N-(tetrahydro-2H-pyran-4-yl)-
- CBNumber:
- CB89636763
- Molecular Formula:
- C24H26N6O2
- Molecular Weight:
- 430.5
- MDL Number:
- MOL File:
- 2220141-46-6.mol
- MSDS File:
- SDS
VU6007477 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| aablocks | AA0248ZV | VU6007477 95% | 2220141-46-6 | 10mg | $90 | 2026-06-01 | Buy |
| aablocks | AA0248ZV | VU6007477 95% | 2220141-46-6 | 25mg | $170 | 2026-06-01 | Buy |
| aablocks | AA0248ZV | VU6007477 95% | 2220141-46-6 | 50mg | $288 | 2026-06-01 | Buy |
| aablocks | AA0248ZV | VU6007477 95% | 2220141-46-6 | 100mg | $489 | 2026-06-01 | Buy |
VU6007477 Chemical Properties, Uses, Production
Description
VU6007477 is a novel M1 PAM. VU6007477 resulted in good rat M1 PAM potency (EC50 = 230 nM, 93% ACh max), minimal M1 agonist activity (agonist EC50 > 10 μM), good CNS penetration (rat braiplasma Kp = 0.28, Kp,uu = 0.32; mouse Kp = 0.16, Kp,uu = 0.18), and no cholinergic adverse events (AEs, e.g., seizures).
Uses
VU6007477 is a brain-penetrant, selective M1 positive allosteric modulator (PAM) with an EC50 value of 230 nM. VU6007477 is also a human P-glycoprotein (P-gp) substrate with moderate permeability. VU6007477 displays improved central nervous system (CNS) penetration over the hydroxylated congeners. VU6007477 a pyranyl amide derivative, which is promising for research of robust cholinergic seizure activity[1].
References
[1] Engers JL, et al. VU6007477, a Novel M1 PAM Based on a Pyrrolo[2,3-b]pyridine Carboxamide Core Devoid of Cholinergic Adverse Events. ACS Med Chem Lett. 2018 Sep 4;9(9):917-922. DOI:10.1021/acsmedchemlett.8b00261
VU6007477 Preparation Products And Raw materials
Raw materials
Preparation Products
VU6007477 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd | 15317229551 | 15151849396@163.com | China | 964 | 58 |
| ShangHai ChuanQian Chemcial Technique Centre | 15869524721 | 3525679403@qq.com | China | 4565 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| TargetMol Chemicals Inc. | 13564774135 | marketing@targetmol.com | United States | 19950 | 58 |
