4-Fluoroisoquinoline
- CAS No.
- 394-67-2
- Chemical Name:
- 4-Fluoroisoquinoline
- Synonyms
- 4-fluoroisoquinoline sulfate;4-FLUOROISOQUINOLINE;4-Floro isoquinoli11e;Isoquinoline, 4-fluoro-;4-Fluoroisoquinoline 95+%;4-Fluoroisoquinoline ISO 9001：2015 REACH
- CBNumber:
- CB8971782
- Molecular Formula:
- C9H6FN
- Molecular Weight:
- 147.15
- MDL Number:
- MFCD06656128
- MOL File:
- 394-67-2.mol
- MSDS File:
- SDS
| Melting point | 34 °C |
|---|---|
| Boiling point | 240℃ |
| Density | 1.216 |
| refractive index | 1.5914 |
| Flash point | 99℃ |
| storage temp. | 2-8°C |
| form | powder to lump |
| pka | 3.45±0.10(Predicted) |
| color | White to Light yellow |
| InChI | InChI=1S/C9H6FN/c10-9-6-11-5-7-3-1-2-4-8(7)9/h1-6H |
| InChIKey | VFFQGPWQVYUFLV-UHFFFAOYSA-N |
| SMILES | C1C2=C(C=CC=C2)C(F)=CN=1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319-H315 | |||||||||
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362 | |||||||||
| HS Code | 2933491090 | |||||||||
| NFPA 704 |
|
4-Fluoroisoquinoline price More Price(60)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | F1057 | 4-Fluoroisoquinoline | 394-67-2 | 250MG | $140 | 2026-04-30 | Buy |
| AstaTech | 62060 | 4-FLUOROISOQUINOLINE 95% | 394-67-2 | 0.25G | $25 | 2026-04-30 | Buy |
| AstaTech | 62060 | 4-FLUOROISOQUINOLINE 95% | 394-67-2 | 1G | $36 | 2026-04-30 | Buy |
| AstaTech | 62060 | 4-FLUOROISOQUINOLINE 95% | 394-67-2 | 5G | $134 | 2026-04-30 | Buy |
| Biosynth | FF66744 | 4-Fluoroisoquinoline | 394-67-2 | 5g | $181.45 | 2026-06-04 | Buy |
4-Fluoroisoquinoline Chemical Properties, Uses, Production
Uses
4-fluoroisoquinoline is a useful research chemical.
Synthesis
1532-97-4
394-67-2
General procedure for the synthesis of 4-fluoroisoquinoline from 4-bromoisoquinoline: A solution of 4-bromoisoquinoline (20 g, 96.6 mmol) dissolved in 144 mL of THF was added slowly and dropwise to a 760 mL THF solution containing n-butyllithium (133 mL, 332.5 mmol, 2.5 M in THF) at -65 °C. After the dropwise addition was completed, the reaction mixture was continued to be stirred at -65 °C for 30 min. Subsequently, a solution of N-fluorobenzenesulfonimide (66.68 g, 211.7 mmol) dissolved in 216 mL THF was added dropwise at the same temperature. After addition, the reaction was maintained at -65 °C for 1 hour. Upon completion of the reaction, the mixture was slowly warmed to room temperature and the reaction was quenched by the addition of 300 mL of saturated aqueous ammonium chloride. The reaction mixture was extracted with ethyl acetate (300 mL x 3), and the combined organic phases were washed with 300 mL of saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (elution gradient: 0-100% ethyl acetate/petroleum ether) to afford 4-fluoroisoquinoline (8.5 g, red oil, yield: 60%).
References
[1] Journal of the American Chemical Society, 2014, vol. 136, # 10, p. 3792 - 3795
[2] Patent: US2017/37050, 2017, A1. Location in patent: Paragraph 0301; 0302
[3] Patent: US2007/179127, 2007, A1. Location in patent: Page/Page column 47-48
[4] Patent: US2009/48223, 2009, A1. Location in patent: Page/Page column 101
[5] Patent: US2010/93789, 2010, A1. Location in patent: Page/Page column 46
4-Fluoroisoquinoline Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| AstaTech (Chengdu) Pharma. Co., Ltd. | 15928766785 15928766785 | wupengcheng@astatech.cn | China | 1998 | 55 |
| Beijing HwrkChemical Technology Co., Ltd | 89508211 18501085097 | sales.bj@hwrkchemical.com | China | 9407 | 55 |
| Chembon Pharmaceutical Co., Ltd. | 028-84252981 18583719936 | sales@chembon.com.cn | China | 854 | 64 |
| TOKYO CHEMICAL INDUSTRY CO., LTD. | 03-36680489 | Sales-JP@TCIchemicals.com | Japan | 28364 | 80 |
| TCI Europe | 320-37350700 | sales@tcieurope.eu | Europe | 23654 | 75 |
| TCI AMERICA | 800-4238616 | sales@tciamerica.com | Americas | 23636 | 75 |
| SynAsst Chemical. | 021-60343070 | China | 12731 | 55 | |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Finetech Industry Limited | 027-87465837 19945049750 | sales@finetechnology-ind.com | China | 9331 | 58 |
| Shanghai HuanChuan Industry Co.,Ltd. | 021-61478794 | sales@hcshhai.com | China | 9781 | 50 |
View Latest Price from 4-Fluoroisoquinoline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | 4-Fluoroisoquinoline
394-67-2
|
$1.10 | 1g | 99.00% | 100 Tons | Dideu Industries Group Limited | |
 |
2026-08-10 | 4-Fluoroisoquinoline
394-67-2
|
$1.00 | 1kg | 98 | 100 | S&Y Biochem Co.,Ltd | |
 |
2026-06-30 | 4-Fluoroisoquinoline
394-67-2
|
1kg | 99% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd |
-
- 4-Fluoroisoquinoline
394-67-2
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 4-Fluoroisoquinoline
394-67-2
- $1.00
- 98
- S&Y Biochem Co.,Ltd
-
- 4-Fluoroisoquinoline
394-67-2
- $0.00
- 99%
- Shaanxi Dideu New Materials Co. Ltd
