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2-Pyrimidineethanesulfonamide, N-[4-(2,6-dimethoxyphenyl)-5-(5-methyl-3-pyridinyl)-4H-1,2,4-triazol-3-yl]-α,5-dimethyl-β-(1-methylethoxy)-, (αS,βS)-

2-Pyrimidineethanesulfonamide, N-[4-(2,6-dimethoxyphenyl)-5-(5-methyl-3-pyridinyl)-4H-1,2,4-triazol-3-yl]-α,5-dimethyl-β-(1-methylethoxy)-, (αS,βS)- Structure
2-Pyrimidineethanesulfonamide, N-[4-(2,6-dimethoxyphenyl)-5-(5-methyl-3-pyridinyl)-4H-1,2,4-triazol-3-yl]-α,5-dimethyl-β-(1-methylethoxy)-, (αS,βS)- structure
CAS No.
2049973-02-4
Chemical Name:
2-Pyrimidineethanesulfonamide, N-[4-(2,6-dimethoxyphenyl)-5-(5-methyl-3-pyridinyl)-4H-1,2,4-triazol-3-yl]-α,5-dimethyl-β-(1-methylethoxy)-, (αS,βS)-
Synonyms
AM-8123;2-Pyrimidineethanesulfonamide, N-[4-(2,6-dimethoxyphenyl)-5-(5-methyl-3-pyridinyl)-4H-1,2,4-triazol-3-yl]-α,5-dimethyl-β-(1-methylethoxy)-, (αS,βS)-
CBNumber:
CB89819645
Molecular Formula:
C27H33N7O5S
Molecular Weight:
567.67
MDL Number:
MOL File:
2049973-02-4.mol
MSDS File:
SDS
Last updated:2026-07-27 17:00:41
Request For Quotation

2-Pyrimidineethanesulfonamide, N-[4-(2,6-dimethoxyphenyl)-5-(5-methyl-3-pyridinyl)-4H-1,2,4-triazol-3-yl]-α,5-dimethyl-β-(1-methylethoxy)-, (αS,βS)- Properties

Boiling point 754.1±70.0 °C(Predicted)
Density 1.33±0.1 g/cm3(Predicted)
pka 4.07±0.10(Predicted)

2-Pyrimidineethanesulfonamide, N-[4-(2,6-dimethoxyphenyl)-5-(5-methyl-3-pyridinyl)-4H-1,2,4-triazol-3-yl]-α,5-dimethyl-β-(1-methylethoxy)-, (αS,βS)- price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0202652 AM-8123 99.89% 2049973-02-4 1mg $379 2026-06-04 Buy
ChemScene CS-0202652 AM-8123 99.89% 2049973-02-4 5mg $932 2026-06-04 Buy
ChemScene CS-0202652 AM-8123 99.89% 2049973-02-4 10mg $1305 2026-06-04 Buy
ChemScene CS-0202652 AM-8123 99.89% 2049973-02-4 25mg $2085 2026-06-04 Buy
Biorbyt Ltd orb1691307 AM-8123 99.76%(Mayvarybetweenbatches) 2049973-02-4 1mg $340 2026-05-06 Buy
Product number Packaging Price Buy
CS-0202652 1mg $379 Buy
CS-0202652 5mg $932 Buy
CS-0202652 10mg $1305 Buy
CS-0202652 25mg $2085 Buy
orb1691307 1mg $340 Buy

2-Pyrimidineethanesulfonamide, N-[4-(2,6-dimethoxyphenyl)-5-(5-methyl-3-pyridinyl)-4H-1,2,4-triazol-3-yl]-α,5-dimethyl-β-(1-methylethoxy)-, (αS,βS)- Chemical Properties,Uses,Production

Uses

AM-8123 is an orally active and potent APJ agonist. AM-8123 inhibits Forskolin-stimulated cAMP production and promotes Gα protein activation. AM-8123 can be used for the research of cardiovascular disease[1].

in vivo

AM-8123 (100 mg/kg; p.o.) results in sustained improvement in systolic function and decreases both EDV and ESV as measured by echocardiography but not by the invasive pressure-volume conductance catheter at study termination[1].
AM-8123 (0.035, 0.09, 0.9, and 9 mg/kg; i.v.) improves cardiovascular function[1].
AM-8123 exhibits appreciably greater oral bioavailability in rats and dogs relative to pyr-apelin-13. AM-8123 infusion results in an increase in EF, SV, and dP/dt max at submicromolar unbound plasma concentrations with minimal change in HR, indicating that acute infusion of AM-8123 is associated with an improvement in several markers of cardiac function. AM-8123 is a more potent mediator of both ERK and AKT phosphorylation relative to pyr-apelin-13[1].

Animal Model:Lewis rats (2~3 months old)[1]
Dosage:100 mg/kg
Administration:P.o.
Result:Resulted in sustained improvement in systolic function.
Decreased both EDV and ESV as measured by echocardiography but not by the invasive pressure-volume conductance catheter at study termination.
Animal Model:Rats[1]
Dosage:0.035, 0.09, 0.9, and 9 mg/kg
Administration:I.v.
Result:Improved cardiovascular function.

References

[1] Ason B, et al. Cardiovascular response to small-molecule APJ activation. JCI Insight. 2020;5(8):e132898. Published 2020 Apr 23. doi:10.1172/jci.insight.132898

2-Pyrimidineethanesulfonamide, N-[4-(2,6-dimethoxyphenyl)-5-(5-methyl-3-pyridinyl)-4H-1,2,4-triazol-3-yl]-α,5-dimethyl-β-(1-methylethoxy)-, (αS,βS)- Preparation Products And Raw materials

Raw materials

Preparation Products

2-Pyrimidineethanesulfonamide, N-[4-(2,6-dimethoxyphenyl)-5-(5-methyl-3-pyridinyl)-4H-1,2,4-triazol-3-yl]-α,5-dimethyl-β-(1-methylethoxy)-, (αS,βS)- Suppliers

Global( 4)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11963 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29874 58
Shanghai Amole Biotechnology Co., Ltd. 13370042665 18916960931 2596183085@qq.com China 17234 58
Supplier Advantage
TargetMol Chemicals Inc. 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
TargetMol Chemicals Inc. 58
Shanghai Amole Biotechnology Co., Ltd. 58

View Lastest Price from 2-Pyrimidineethanesulfonamide, N-[4-(2,6-dimethoxyphenyl)-5-(5-methyl-3-pyridinyl)-4H-1,2,4-triazol-3-yl]-α,5-dimethyl-β-(1-methylethoxy)-, (αS,βS)- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
AM-8123 pictures 2026-07-27 AM-8123
2049973-02-4
 $293.00-722.00 99.76% 10g TargetMol Chemicals Inc.
  • AM-8123 pictures
  • AM-8123
    2049973-02-4
  • $293.00-722.00
  • 99.76%
  • TargetMol Chemicals Inc.

2-Pyrimidineethanesulfonamide, N-[4-(2,6-dimethoxyphenyl)-5-(5-methyl-3-pyridinyl)-4H-1,2,4-triazol-3-yl]-α,5-dimethyl-β-(1-methylethoxy)-, (αS,βS)- Spectrum

2-Pyrimidineethanesulfonamide, N-[4-(2,6-dimethoxyphenyl)-5-(5-methyl-3-pyridinyl)-4H-1,2,4-triazol-3-yl]-α,5-dimethyl-β-(1-methylethoxy)-, (αS,βS)-(2049973-02-4)1HNMR

2049973-02-4(2-Pyrimidineethanesulfonamide, N-[4-(2,6-dimethoxyphenyl)-5-(5-methyl-3-pyridinyl)-4H-1,2,4-triazol-3-yl]-α,5-dimethyl-β-(1-methylethoxy)-, (αS,βS)-)Related Search:

(2R,3S)-Azelaprag APJ receptor agonist 8 2-Pyrimidineethanesulfonamide, N-[4-(2,6-dimethoxyphenyl)-5-(5-methyl-3-pyridinyl)-4H-1,2,4-triazol-3-yl]-α,5-dimethyl-β-(1-methylethoxy)-, (αS,βS)- Azelaprag Apelin-13 TFA
(Ala13)-Apelin-13 TFA

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2-Pyrimidineethanesulfonamide, N-[4-(2,6-dimethoxyphenyl)-5-(5-methyl-3-pyridinyl)-4H-1,2,4-triazol-3-yl]-α,5-dimethyl-β-(1-methylethoxy)-, (αS,βS)- AM-8123 2049973-02-4 C27H33N7O5S